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Human Growth Hormone as part of IVF protocol?

MandaS08MandaS08 member
in Infertility

My RE is recommending that we use human growth hormone (hgh)(brand name Saizen) on our next IVF cycle.

I've done some reseach and it seems like primarily this is used in women over 40 to help with egg quality-I'm 31.

Also, this is going to add around $1500 on to our meds....thoughts? I know I need to do some more research but I thought I would ask here first.

Has anyone else used this?

TTC since 5/2010
DX with Diminished Ovarian Reserve - AMH of 1.1 - 7/2011; AMH of .42 8/2012BFP 9/1/10-M/C confirmed 9/8/10-Methotrexate 10/6/10
IUI #1 (w/clomid)-9/5/11-BFN ; IUI #2 (w/clomid)-10/5/11 - BFP - 11/1/12-No sac seen; 11/2/11 and 11/9/11-Methotrexate 
IVF #1- ER 2/2; ET 2/5;-Two 8 cell embryos transfered = BFFN
Surprise BFP - 5/7/12
U/S on 6/8/12 - H/B at 128 BPM; U/S on 6/14/12 @ 9wks-No H/B-D&C on 6/17/12
IVF 2.0- ER 10/17; ET 10/20-One 12 cell, one 10 cell and one 8 cell embryo transfered
BFP!   11/16/12 U/S- Two nuggets with perfect heartbeats! EDD 7/10/13

 

5/31/2013- My miracles arrived at 34w2d!  Welcome to the world Harper and Nolan!Lilypie First Birthday tickers

My Blog- http://waitingonaangel.wordpress.com/

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Re: Human Growth Hormone as part of IVF protocol?

  • jillychrisjillychris member

    ** Ticker Warning**

     

    When I went for a 2nd opinion to a clinic with higher success rates than my first, my new RE recommended this for me for IVF #2 (I was 34 at the time.) He said they had seen an increase in quality and therefore, more success. I didn't up going into IVF #2, so not sure what it would have done for me, but I do know that he was able to show me data showing an increase in success with cycles that used Saizen. GL with whatever you decide!!!!

    2/11 Diagnosis: DOR-AMH .62, LPD and MFI-4% Morph
    IVF #1-July 2011 7/9/11-Started Stims
    7/20/11-ER:No eggs in 4/5 follicles. Left the 5th follie intact and converted to an IUI
    8/3/11-Beta #1=BFN,
    Nov, 2011 BFP #1=m/c at 7 wks 3 days
    11/11-AMH .47, IVF #2 March 2012...or not!! Surprise BFP on 2/19. Beta #1=161. Beta #2 305 Our little miracle girl is on her way! Due Oct 29, 2012
    <a href="http://s1207.photobucket.com/albums/bb461/andersenspics/?action=view
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  • k8teeinTXk8teeinTX member
    I haven't used it before, but after our really poor embryos in our last cycle, I'm going to ask my RE about this on Wednesday at our WTF.  I know that AmCheri used it during her cycle and felt she had good results with it.  Sorry I can't be more help, but I'll come back and let you know what my RE says about it!  Good luck!
    ~TTC#1 since 05/10~
    Me (38), DH (43)
    DX: MFI & DOR (FSH=9.9, 7.2, 11.6, 12.3; AMH=.19, .27, .007)
    06/11 IUI#1 (clomid unmonitored)=BFN
    09/11 IVF#1 (long lurpon) converted to IUI#2 due to poor response=BFN
    11/11 IVF#1.2 (MDLF) 5R/5M/4F w/ICSI 3dt of 3=BFN
    1/12 hysteroscopy to remove polyps
    3/12 IVF #2 (MDLF) 7R/5M/5F w/ICSI 3dt of 3=BFP!!! Beta #1 (14dpo)=113, Beta #2 (16 dpo)=385, Beta #3 (23 dpo)=3267, Beta #4 (30 dpo)=15,494 
    first u/s (6 wks, 3 days) reveals possible cervical pregnancy
    confirmed cervical pregnancy with fetal HB (7 wks, 2 days)
    5 days in the hospital to end pregnancy (8 wks, 3 days) and monitor bleeding + MTX injects
    6/1/12 hCG finally at zero!!
    6/21/12 hysteroscopy #2=all clear!
    8/12 IVF#3 (EPP/MDLF) 4R/4F w/ICSI, 3dt of 4=chem pg
    10/12 IVF#4 (MDLF) 10R/9M/7F w/ICSI, 5dt of 2, Beta#1 (14dpo)=193, Beta #2 (16dpo)=741, Beta #3 (19dpo)=3949, Beta #4 (5w5d)=35,000+, Beta #5 (6w5d)=91,000+
    04/13 Hospital bed rest at 24wks due to severe cervical shortening and dilation
    05/13 Home bed rest for remainder of pregnancy
    06/26/13 Baby Boy "O" born via unplanned c-section (failure to progress ironically!) after my water broke 
    ON HIS DUE DATE!!!!
    Lilypie Breastfeeding tickers
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  • eastwesteast78eastwesteast78 member
    I know my clinic (CCRM) uses Saizen in some cases, and from the blogs I've read, definitely not always in women over 40.  I have my beta tomorrow and if it is negative, I am going to request that we use Saizen in my second cycle.  From what I understand, it can help quality, but not quantity.   
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  • LosingHope123LosingHope123
    I used low dose HCG injections during my IVF 3 and 4.. I got MANY more eggs those 2 cycles than the first 2... We haven't had a successful BFP yet so I am not sure about the quality but we did have more successful retrievals.. Good luck!! ( I was 27 at the time BTW.. definitely not just for the over 40 crowd :-)
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  • Temp878586125009588Temp878586125009588 member

    I used a low dose HCG for both my IVF's. (I'm 29) I'm not sure if there was a reason they put me on it or if it's just standard in their practice since I was given instruction for it both times. (Only one of the 2 IVF's made it to ER and ET though). I also am not sure if my lower AMH has anything to do with their decision either. (I'm not sure if I was helpful, but I did use it and I'm not ovre 40 either)

    Good Luck.

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  • ksfryeksfrye member
    I used it and I'm 28.  My RE was pretty happy with the amount of eggs we retrieved...17, 11 mature.  I am switching RE offices because our old RE was a jerk, but I hope my new RE is willing to use it for IVF #2.
    Happily married Since May 2008. TTC#1 Since May 2010.
    Me: 29, Mild DOR
    DH: 31, SE mostly normal, 1st SE morph 5%, 2nd SE morph 15%...yeah!.
    BFP July 2011, Natural MC August 2011.
    3 cycles of 50mg Clomid = BFN
    *New RE* Feb/Mar 2012 100 mg Clomid + Trigger + IUI = BFN
    *3rd RE* April-June -Break Cycles begin prep for IVF by doing 2 Heparin injects daily....fun fun!
    IVF #1 - ER 7/19, ET 7/24, 2 beautiful embies transferred. Beta 8/2 = BFN
    *New RE...yes again* FET Nov 2012 with our lone ranger = BFFN
    RE Suggests Trying IUI Again, Jan. 2013 IUI #2 =BFN
    Feb. 2013 IUI #3 = BFP!!!, Beta #1 (15dpIUI) = 90, Beta #2 (17dpIUI) = 210, U/S Scheduled for 3/18
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