Infertility

MFI rears its ugly head..UPDATE

Well 3 samples later, we are in the same boat. SAs are showing 0% motility. The people at the lab & doctors seem "baffled." So odd that motile sperm was found in the first SA back in April, again in biopsy, again in June & now nothing, of course, just in time for my ER next week. Uro is back involved & on call for sperm aspiration on ER day which it sounds like we'll need! Just need some kind of reassurance at this point uro will find motile sperm that day. He says he thinks he will but I am not too confidant in that since DH has no diagnosis! Left uro a message & see RE Tom morning. Guess this is just a vent really..as if ER isn't stressful enough, they'd better find sperm to fertilize with!! Ugh. Thanks for reading if you made it all the way through...
TTC since June 2011
DX: DH (30) severe MFI, severely low count & low motility
Me (32): all clear
Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
2nd SA 6/18/12: sample is "adequate for ICSI"
Plan: IVF/ICSI July 2012!
ER: 7/26/12. 15 eggs retrieved, all mature.
TESE/TESA/aspiration from epididymis, no motile sperm found :(
froze all eggs, the saga of praying for good sperm continues.
8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
SA 8/17/12: Zero sperm
SA 8/23/12: Zero sperm
9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
All 3 survived the thaw on 11/15/12!
FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
moving on to DS
DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
1st u/s 4/8/13 shows one gestational sac
2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
A/S 7/22/13: IT'S A BOY!!
PAIF/SAIF Always Welcome
[IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
BabyFruit Ticker

Re: MFI rears its ugly head..UPDATE

  • I am so sorry you are having these problems. The uro aspirating on the day of sounds like a good plan. Perhaps your DH should go to acupuncture this week if nothing else then just to relax a bit. GL

     

    6 m/c
    Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
    Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
    1 Clomid/Ovidrel BFN May 2011
    Natural cycle Aug 2011 BFP M/C 4 Weeks
    1 IUI Sept 2011 BFP M/c 7 weeks
    Provera Dec 2011 BFP M/C 3 Weeks
    DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
    IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
    IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
    Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
    Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
    Went to Beer Center- high tnf, low lad, implantation failure
    Nov/Dec 2012 LIT Treatment
    Dec 12 Humira
    Jan 2013 BFP
    Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
    Miracle Born August 2013 Premature

    Yours doesn't have to be a sad story



    image
    image


    Lilypie - (ugiy)


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  • Does your RE/uro suggest using DS as a back-up plan?   I know my clinic will buy back any vials that you buy and then don't use. 

    GL!

     TTC #1 since 6/09
    Dx: PCOS and MFI
    3 IUIs, 4 IVFs = BFFN
      3rd RE: IVF #5/FET = BFP
    14dp5dt=1170 16dp5dt=2573

    1st u/s=
    TWINS!
    It's a Boy and a Girl!

    Born at 34w3d! 
     

  • I know exactly how frustrating this can be.  Our situation may be a little different, since DH has retrograde ejaculation and sperm had to be spun out of urine sample, but hoping our story can give some reassurance just the same.

    DH didn't even start producing sperm until January 2012.  This was due to chemo therapy in 2009.  All samples (3 done from Jan - March) showed that sperm were nonmotile.  They also couldn't get many in a count, so we chose to do a biopsy the day of ER.  We also had DS as a backup so that the entire IVF wouldn't be ruined if biopsy was a bust.   We were told that even though we were doing ICSI, they wouldn't use nonmotile sperm.  Fortunately, the biopsy was a success.  Not only did they have enough sperm to fertilize all eggs, but they had several vials to freeze too.

    Hopefully you'll not only get some answers from Uro and RE, but you'll find motile sperm day of ER.  I'll be keeping my fx for you and YH.

                          

    PAIFW/SAIFW

    DS1 born July 2002 (previous marriage).

    TTC since Oct 08. DH Dx w/testicular cancer March 09.
    MFI due to retrograde ejaculation/azoospermia.
    5/2 IVF #1 cancelled due to large follie.
    6/14 start Lupron for IVF #1.2. 6/22 start stims.
    7/4 ER and Biopsy.
    7/9 Transferred 2 (1-4BB and 1-3BB) embryos.  4 frosties.
    7/15 +HPT 6dp5dt. 7/18 Beta #1: 193. 7/20 Beta #2: 415.
    8/10 1st u/s - It's triplets!

    Baby Birthday Ticker Ticker


  • imagehootie123:

    Does your RE/uro suggest using DS as a back-up plan?   I know my clinic will buy back any vials that you buy and then don't use. 

    GL!

    Thanks for the suggestion. We ruled that option out with uro a while ago. While we understand & respect that as an option, it's just not for us, especially since all tests have shown DH is capable of producing motile sperm. What we have talked about is freezing my eggs should no sperm be found that day and guess we'll just have to wait & hope that DH will produce a sample with some motility again in the future. 

     

    TTC since June 2011
    DX: DH (30) severe MFI, severely low count & low motility
    Me (32): all clear
    Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
    Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
    Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
    2nd SA 6/18/12: sample is "adequate for ICSI"
    Plan: IVF/ICSI July 2012!
    ER: 7/26/12. 15 eggs retrieved, all mature.
    TESE/TESA/aspiration from epididymis, no motile sperm found :(
    froze all eggs, the saga of praying for good sperm continues.
    8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
    Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
    SA 8/17/12: Zero sperm
    SA 8/23/12: Zero sperm
    9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
    All 3 survived the thaw on 11/15/12!
    FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
    moving on to DS
    DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
    DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
    1st u/s 4/8/13 shows one gestational sac
    2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
    3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
    A/S 7/22/13: IT'S A BOY!!
    PAIF/SAIF Always Welcome
    [IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
    BabyFruit Ticker
  • imageLuvWIfootball:

    I know exactly how frustrating this can be.  Our situation may be a little different, since DH has retrograde ejaculation and sperm had to be spun out of urine sample, but hoping our story can give some reassurance just the same.

    DH didn't even start producing sperm until January 2012.  This was due to chemo therapy in 2009.  All samples (3 done from Jan - March) showed that sperm were nonmotile.  They also couldn't get many in a count, so we chose to do a biopsy the day of ER.  We also had DS as a backup so that the entire IVF wouldn't be ruined if biopsy was a bust.   We were told that even though we were doing ICSI, they wouldn't use nonmotile sperm.  Fortunately, the biopsy was a success.  Not only did they have enough sperm to fertilize all eggs, but they had several vials to freeze too.

    Hopefully you'll not only get some answers from Uro and RE, but you'll find motile sperm day of ER.  I'll be keeping my fx for you and YH.

     

    Thanks, Luv! :) that is reassuring. MFI sucks!!!! But you & your beautiful BFP give me hope :) 

    TTC since June 2011
    DX: DH (30) severe MFI, severely low count & low motility
    Me (32): all clear
    Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
    Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
    Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
    2nd SA 6/18/12: sample is "adequate for ICSI"
    Plan: IVF/ICSI July 2012!
    ER: 7/26/12. 15 eggs retrieved, all mature.
    TESE/TESA/aspiration from epididymis, no motile sperm found :(
    froze all eggs, the saga of praying for good sperm continues.
    8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
    Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
    SA 8/17/12: Zero sperm
    SA 8/23/12: Zero sperm
    9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
    All 3 survived the thaw on 11/15/12!
    FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
    moving on to DS
    DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
    DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
    1st u/s 4/8/13 shows one gestational sac
    2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
    3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
    A/S 7/22/13: IT'S A BOY!!
    PAIF/SAIF Always Welcome
    [IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
    BabyFruit Ticker
  • imageluvboston:

    I am so sorry you are having these problems. The uro aspirating on the day of sounds like a good plan. Perhaps your DH should go to acupuncture this week if nothing else then just to relax a bit. GL

    Thank you! He does need to relax..we both do! :) 

    TTC since June 2011
    DX: DH (30) severe MFI, severely low count & low motility
    Me (32): all clear
    Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
    Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
    Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
    2nd SA 6/18/12: sample is "adequate for ICSI"
    Plan: IVF/ICSI July 2012!
    ER: 7/26/12. 15 eggs retrieved, all mature.
    TESE/TESA/aspiration from epididymis, no motile sperm found :(
    froze all eggs, the saga of praying for good sperm continues.
    8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
    Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
    SA 8/17/12: Zero sperm
    SA 8/23/12: Zero sperm
    9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
    All 3 survived the thaw on 11/15/12!
    FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
    moving on to DS
    DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
    DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
    1st u/s 4/8/13 shows one gestational sac
    2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
    3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
    A/S 7/22/13: IT'S A BOY!!
    PAIF/SAIF Always Welcome
    [IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
    BabyFruit Ticker
  • I'm so sorry.  It sounds like you and I are close to being in the same boat.  My DH usually has a few sperm but sometimes nothing and the ones that he does have are barely moving. Our RE feels this (sperm quality) is the cause of our two failed IVF's  We are hoping for there to be good sperm at next month's biopsy and hopefully we can freeze it.  On the plus side our MFI uro's office is straight across the hall from our RE.

    Never in my life did I think I'd be praying for good sperm. :) 

    My DH is actually considering acupuncture and is taking supplements.  We don't expect a cure but it's all we can do. Update us on how it all goes. Good luck to you!!!!!     

     36 DH 33 TTC for over 3 years
    First mini-IVF Sept 2011... Only 1 egg! ... BFN
    Switching RE
    IVF#2 May 2012 9 eggs and only 2 sperm, WTH!
    BFN
    IVF #3 March 2013~Tesa with back-up Donor Sperm,Tesa, unsuccessful used DS~ Chemical :(   

    Switching RE's within practice

    2 frosties waiting for us, November 2013!!!!!   Transferred 2 "average" blasts 11/20/2013
    BFP!!!!!!!  Boy/Girl Twins!!!!!! Due 08/08/2014

    My Blog




    *~God gives his hardest battles to his toughest solders. Unknown.
    image
  • Just wanted to say that I am sorry this is happening to you.  I'm crossing my fingers that things go well for you.
    Married July 2011; TTC since April 2011; DX: MFI
    IVF #1 in August 2012: BFP!
    L was born on May 5, 2013, 8lb. 6oz.
    PAIF/SAIF welcome!

    Our Project Make A Baby

    Baby Birthday Ticker Ticker
  • imagemelkel559:
    imageLuvWIfootball:

    I know exactly how frustrating this can be.  Our situation may be a little different, since DH has retrograde ejaculation and sperm had to be spun out of urine sample, but hoping our story can give some reassurance just the same.

    DH didn't even start producing sperm until January 2012.  This was due to chemo therapy in 2009.  All samples (3 done from Jan - March) showed that sperm were nonmotile.  They also couldn't get many in a count, so we chose to do a biopsy the day of ER.  We also had DS as a backup so that the entire IVF wouldn't be ruined if biopsy was a bust.   We were told that even though we were doing ICSI, they wouldn't use nonmotile sperm.  Fortunately, the biopsy was a success.  Not only did they have enough sperm to fertilize all eggs, but they had several vials to freeze too.

    Hopefully you'll not only get some answers from Uro and RE, but you'll find motile sperm day of ER.  I'll be keeping my fx for you and YH.

     

    Thanks, Luv! :) that is reassuring. MFI sucks!!!! But you & your beautiful BFP give me hope :) 

    Aww, thanks hun!  I spent the last 3 yrs lurking/posting on this board and I'm glad to "hopefully" be one of those stories that brings encouragement to others.  I know it's what kept me going the whole time.

                          

    PAIFW/SAIFW

    DS1 born July 2002 (previous marriage).

    TTC since Oct 08. DH Dx w/testicular cancer March 09.
    MFI due to retrograde ejaculation/azoospermia.
    5/2 IVF #1 cancelled due to large follie.
    6/14 start Lupron for IVF #1.2. 6/22 start stims.
    7/4 ER and Biopsy.
    7/9 Transferred 2 (1-4BB and 1-3BB) embryos.  4 frosties.
    7/15 +HPT 6dp5dt. 7/18 Beta #1: 193. 7/20 Beta #2: 415.
    8/10 1st u/s - It's triplets!

    Baby Birthday Ticker Ticker


  • imagefiresiren:

    I'm so sorry.  It sounds like you and I are close to being in the same boat.  My DH usually has a few sperm but sometimes nothing and the ones that he does have are barely moving. Our RE feels this (sperm quality) is the cause of our two failed IVF's  We are hoping for there to be good sperm at next month's biopsy and hopefully we can freeze it.  On the plus side our MFI uro's office is straight across the hall from our RE.

    Never in my life did I think I'd be praying for good sperm. :) 

    My DH is actually considering acupuncture and is taking supplements.  We don't expect a cure but it's all we can do. Update us on how it all goes. Good luck to you!!!!!     

    Thanks!! Yep, sounds similar. DH's last sample (the good one in June) had good motility & higher numbers. I am so peeved we didn't freeze that sample. Docs thought for sure they'd get another good one to freeze...so far, wrong!!

    Sorry to hear of your failed IVF cycles. Hope your approaching procedures do the trick! 

    TTC since June 2011
    DX: DH (30) severe MFI, severely low count & low motility
    Me (32): all clear
    Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
    Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
    Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
    2nd SA 6/18/12: sample is "adequate for ICSI"
    Plan: IVF/ICSI July 2012!
    ER: 7/26/12. 15 eggs retrieved, all mature.
    TESE/TESA/aspiration from epididymis, no motile sperm found :(
    froze all eggs, the saga of praying for good sperm continues.
    8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
    Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
    SA 8/17/12: Zero sperm
    SA 8/23/12: Zero sperm
    9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
    All 3 survived the thaw on 11/15/12!
    FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
    moving on to DS
    DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
    DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
    1st u/s 4/8/13 shows one gestational sac
    2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
    3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
    A/S 7/22/13: IT'S A BOY!!
    PAIF/SAIF Always Welcome
    [IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
    BabyFruit Ticker
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