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Biopsy results are in...WTF?? (Long)

melkel559melkel559 member
in Infertility

Ok, MFI friends, I am wondering if any of you have been in a similar situation and may have any insight/advice....

In my last post I mentioned that sperm was found in the left teste, none were seen in the sample from the right..these are the results from the IVF people/andrology lab. Uro calls today to say he received the report from the pathologist indicating normal sperm production in both testicles. Let's just say, he seemed "stumped." He plans to review the samples with the pathologist tomorrow. I guess he doesn't think it's obstructive because of the normal volume in the ejaculate or something along those lines...why is this normal sperm not coming out then? That is what he needs to review with the pathologist apparently and why the discrepancy between the two samples (2 samples from each side were taken and the same tissue was sent to both the andrology lab and the pathologist.)

Uggh I do like our uro and it's great that he takes time to call but he speaks so fast I feel like my head is spinning. Bottom line is he needs to call us tomorrow. I am wondering if he'll recommend another SA (only one was done which started all this, I know we should've pushed for another). We had our IVF orientation today & I am supposed to start my period today or tomorrow & meet with RE to start first steps for IVF/ICSI...now I'm like WTF? Do I move forward with that or not? If we are going this route, we want to get this ball rolling!  Couldn't reach RE today so guess will have to wait until tomorrow, hopefully uro calls us sooner rather than later. Just thought I would throw this out there in the meantime to my expert panel of ladies!

And as always, best of luck to everyone on here dealing with the all-so nasty IF. :)

 

TTC since June 2011
DX: DH (30) severe MFI, severely low count & low motility
Me (32): all clear
Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
2nd SA 6/18/12: sample is "adequate for ICSI"
Plan: IVF/ICSI July 2012!
ER: 7/26/12. 15 eggs retrieved, all mature.
TESE/TESA/aspiration from epididymis, no motile sperm found :(
froze all eggs, the saga of praying for good sperm continues.
8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
SA 8/17/12: Zero sperm
SA 8/23/12: Zero sperm
9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
All 3 survived the thaw on 11/15/12!
FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
moving on to DS
DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
1st u/s 4/8/13 shows one gestational sac
2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
A/S 7/22/13: IT'S A BOY!!
PAIF/SAIF Always Welcome
[IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
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Re: Biopsy results are in...WTF?? (Long)

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    kaf7kaf7 member
    Weird. I'm just not knowledgeable enough to really comment but I hope they have some answers for you so you can make some decisions.
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    L12abellL12abell member

    I'm definitely not as well informed as most of these ladies, but I would definitely have another SA.  We are awaiting SA #3 and hoping to get some sperm to freeze this time before we start planning for IVF with ICSI.  DH has not had any biopsies or anything.  If he has another 0 count I guess we may move to that?

    Good luck!

    Anniversary
    Married 9/29/2007
    TTC 11/2010
    Me: HSG 4/2012 Tubes Clear, Hypothyroid, PCOS
    DH: MFI, SA #1 2 million, SA #2 no sperm, SA #3 7 million total
    DH is now on HSG shots 2x week, 2.5 MG Letrozole 2x week, Vitamin B Complex, 600 mg Alpha Lipoic Acid, and 400 mg CoQ-10.
    UPDATE:
    3/2013 IUI with Femara, BFN
    4/2013 IUI with Femara, BFN
    5/2013 IUI with Femara, BFN
    8/2013 IVF with Femara, Bravelle, and Lupron, 4 eggs retrieved, 3 fertilized, 3 grade 2 Blastocysts transferred day 5, BFN
    8/2013 Exploring domestic infant adoption

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    maggie2324maggie2324 member
    Hopefully the first sample was a fluke and the next one comes back much better. Weird that they would do a biopsy after only one SA.
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    melkel559melkel559 member
    Thanks, everyone. Yeah, I am hoping for another SA. They didn't want to do one because they said the count was so severely low that another wouldn't have made a difference...now I wonder about that! Waiting on uro, waiting on RE, waiting on AF, waiting waiting waiting uggghhhh...I am not a patient person either! :)
    TTC since June 2011
    DX: DH (30) severe MFI, severely low count & low motility
    Me (32): all clear
    Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
    Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
    Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
    2nd SA 6/18/12: sample is "adequate for ICSI"
    Plan: IVF/ICSI July 2012!
    ER: 7/26/12. 15 eggs retrieved, all mature.
    TESE/TESA/aspiration from epididymis, no motile sperm found :(
    froze all eggs, the saga of praying for good sperm continues.
    8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
    Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
    SA 8/17/12: Zero sperm
    SA 8/23/12: Zero sperm
    9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
    All 3 survived the thaw on 11/15/12!
    FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
    moving on to DS
    DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
    DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
    1st u/s 4/8/13 shows one gestational sac
    2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
    3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
    A/S 7/22/13: IT'S A BOY!!
    PAIF/SAIF Always Welcome
    [IMG]http://i49.tinypic.com/2qmon5u.jpg[/IMG] [IMG]http://i225.photobucket.com/albums/dd243/laurakat24/turkeybaster-1.jpg"[/IMG]Image and video hosting by TinyPic
    BabyFruit Ticker
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    joules12joules12 member
    Sorry that things are so frustrating!  Yes, I agree with the PP that another SA should be done and I'm surprised that more than one wasn't done before moving forward with a procedure as intrusive as a biopsy.  GL!
    TTC since honeymoon in 9/2010
    Me: 39, Dx DOR (FSH = 10.5, AMH = 0.43, best AFC = 10), AMA
    MH: 37, Dx Obstructive Azoospermia, multiple successful sperm retrieval procedures

    1/2012: IVF/ICSI #1 Antagonist = cancelled d/t poor response to max stims
    2/2012: IVF/ICSI #2 MDLF (4R, 4M, 1F) = BFP, saw heartbeat, missed m/c 9w0d, D&E
    8/2012: IVF/ICSI #3 EPP/MDLF (7R, 2M, 1F) = BFN

    12/2012: (New RE) Operative hysteroscopy to remove scar tissue

    1/2013: IVF/ICSI #4 Low-dose stim/Antagonist (AFC=6); ER=1/26 (5R-couldn't access rt ovary, 5M, 4F), ET=1/29 (trans 3) = BFP!; 2/11 beta#1(13dp3dt)=2127, 2/13=3367; twin girls due 10/19/13

    PAIF/SAIF very welcome!

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