Infertility

2 vs. 3 transfer

Ladies, I have been struggling with this decision since the day we found out we would have to do IVF. I need your advice, input, comments, anything... 

We have been trying for a child for 6 years, through many failed cycles, tons of money, and 2 heartbreaking miscarriages, we want this ivf cycle to work so badly it hurts. 

Which leads me to making the decision to put back 2 or 3 so hard. I want a healthy baby or babies, either way I would be forever grateful and happy, however, putting back 3 ( and 3 taking) has so many risks of no carrying to term which would be heartbreaking.  None taking for us would be devastating as well. I am just so torn, and so scared to make the wrong decision. I would rather have 3 babies than none, and do anything I can to keep them safe inside, but I just know its not that easy.

Doc said he always recommends 2, however, its our decision.

Also, I know that my decision will be affected by the quality of the blasts on day 5 when that comes as well. This is just my pre-thoughts on it...

Please dont think im crazy, or irresponsible, or desperate... Oh, wait. I am desperate for a baby.,..

My Blog

Me:26 PCOS, IR, MTHFR c677t/c677t, arcuate uterus DH:27 4% morphology
11/2006 Married My DH
Started trying on Honeymoon
2009/2009 4 failed clomid cycles, many BFN, PCOS Study
4/2010 5 rounds of femara resulted in BFP!
6/2010 Lost our little poppy.
7/2010 DX: MTHFR C677t/C677t
2/23/2011 Starting first IUI cycle. Follistim and ovidrel. Fingers crossed...
First IUI=BFN Second IUI=BFN
9/2011: IUI 3,4,5,6 BFN
1/2012 New year New plan... First consult for IVF.
4/3/2012 First day of our 1st IVF cycle..
5/16 ER 14R 6M 5F (25+ empty follicles)
5/19 ET 3dt of 2 grade A 8 cell embabies!!! Stick baby stick
8dp3dt BFP! Beta#1 12dp3dt 136, #2 14dpt 336, #3 16dpt 845
6/19/2012 7w HB 131!!! 6/27/2012 8w HB 173
Baby Delaney is scheduled to be induced Jan 30, 2013!!

imageimageimageLilypie Pregnancy tickers

Re: 2 vs. 3 transfer

  • I would think that you don't want to put back more than you can handle. Triplets would scare the heck out of me but for others it is something that they could make work. If financially and emotionally you and your husband can handle that, then go for it. If either of you have reservations about it, I would only do two. My RE said with my DOR diagnosis, he would want to put back 3 (if we are lucky to get 3) and I told him no. Only 2 for us. GL to you with this decision and may you have comfort with whatever you choose.
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  • we and both very comfortable with 3 babies. Anything would be a blessing at this point!

    thanks! and GL to you as well! 

    My Blog

    Me:26 PCOS, IR, MTHFR c677t/c677t, arcuate uterus DH:27 4% morphology
    11/2006 Married My DH
    Started trying on Honeymoon
    2009/2009 4 failed clomid cycles, many BFN, PCOS Study
    4/2010 5 rounds of femara resulted in BFP!
    6/2010 Lost our little poppy.
    7/2010 DX: MTHFR C677t/C677t
    2/23/2011 Starting first IUI cycle. Follistim and ovidrel. Fingers crossed...
    First IUI=BFN Second IUI=BFN
    9/2011: IUI 3,4,5,6 BFN
    1/2012 New year New plan... First consult for IVF.
    4/3/2012 First day of our 1st IVF cycle..
    5/16 ER 14R 6M 5F (25+ empty follicles)
    5/19 ET 3dt of 2 grade A 8 cell embabies!!! Stick baby stick
    8dp3dt BFP! Beta#1 12dp3dt 136, #2 14dpt 336, #3 16dpt 845
    6/19/2012 7w HB 131!!! 6/27/2012 8w HB 173
    Baby Delaney is scheduled to be induced Jan 30, 2013!!

    imageimageimageLilypie Pregnancy tickers
  • ASRM has ethical guidelines outlining the number of blasts to transfer, and 3 is reserved for those with a history of successful transfers and are at least 38 years old. If your RE is ethical, the option for 3 is poor, even with poor quality blasts, so it's not even something that you should be thinking all that hard about. Twins have the potential for a lot of problems as well. On this board I've seen so many complications from twins, I wouldn't take carrying multiples of any number lightly at all.

    www.asrm.org/publications/detail.aspx?id=3966

     

    +++
  • Lacyj67Lacyj67 member
    I would put in three to up the chances if I had already had failed attempts and been trying a long time! I say go with your heart because your brain may talk you outta it due to the financial and emotional aspects!!! Good luck!;)
    Me 34 and DH 39 married in aug. 2002
    Did 5 round of clomid 2010 =BFN
     High levels of NK CELLS DX sept.2012 DOR:# 0.02 
    IVF #1 May 2012  ER 4, EF 2, ET 2 =BFN
    MINI IVF Oct.2012  Cancelled 10-27-12
    Ivf #3 Antagonist Protocol April 2013
    Shared cycle..Donor cycled in July Got 12 eggs 9 fertilized and 8 frozen!!
    DE FET #1 Sept. 3rd 2013 FIRST BFP EVER 5dp5dt
    miscarried Sept 24th at 5 weeks 5 days
    Etopic  D&C and hysterscopy Nov 5 2013
    dx with pre genetic blood clotting dec 2013
    FET #2 Jan 31st  2014 
    Miscarried for a second time again at 5 weeks 5 days
    Currently fostering to adopt an amazing little 1 year old boy..P.J!
    FET#3  is Oct 29th 2014
    BFN on fet #3
    Last and FINAL FET coming JAN 28th 2015
    Everyone Welcome






  • imageschlud01:

    we and both very comfortable with 3 babies. Anything would be a blessing at this point!

    So you're happy to risk the health of your babies and yourself, increase the chances of a developmental concerns, or risk pregnancy loss. Good luck!

    Lacy, this is her first IVF. ET is based on IVF history not years TTC.

    +++
  • Honestly, if my doctor recommended two, I'd do two.  I did an eSET for my first IVF, that ended in m/c, and wanted to a eSET for my FET, but my RE strongly recommended putting back two.  Honestly, I'm nervous about it. 

    Do I think I could handle raising healthy twins?  Yes.  Do I think I'd do well, mentally, in a high risk pregnancy or if I miscarry again?  Absolutely not.  In the year I've been on the board, I've seen too many people who were carrying twins and triplets come back because they lost their children - many at later stages in their pregnancies. 

    Me: 35 DH: 37 TTC since 4/2010
    DX: 6/9/2011: Azoo ICSI/IVF only option for biological child
    IVF #1: ER - 9/26 * ET - 10/1 * beta#1 10/13 - 140 * beta#2 10/17 - 477 * beta#3 10/20 - 1101
    1st u/s at 6w6d - one hb * 2nd u/s at 8w3d - no hb detected 11/10/11 * natural m/c 11/13/11
    FET #1 Jan/Feb 2012 - 3 delays - cancelled 2/13
    FET #1.2 - May/June 2012 - ET 6/6/* beta#1 6/15 - 95 * beta #2 6/19 - 322 * beta #3 6/22 - 940
    7/6 1st u/s @ 7 weeks - one beautiful hb - released from RE
    EDD 2/22/2013
    PAIF/SAIF/PGAL welcome
    imageimageimageimage
    BabyFruit Ticker
  • Our RE told us that he would highly recommend us only putting one back because of the high risks multiples come with not only for birth but for defects etc, as well as the fact that I have a bicorunate uterus puts me at a much higher risk for pre term labor. He did however say that if we had poor quality embryo that he would put two in. 

    In the end it's a personal decision, but not one that should be taken lightly with the "two for one" mantality. You should look into the odds of complications carrying triplets that may help you decide if it's worth it to you! Goodluck! :) 

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  • This is your first IVF cycle, so I would NOT put in 3 5 day blasts. Putting in 3 at 5 days does not increase your chance of pregnancy AT ALL, only your chance of multiples.

    If you do a 3 day transfer, then I think transferring 3 is ok. It will increase your chance of pregnancy then. If you don't have 2 blasts on day 5 that are high enough quality to freeze, then 3 would be ok too. That's an atypical situation though because if they see that as a likely outcome, a 3dt would be recommended.

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  • You are 26 years old on your first cycle. If your doctor is willing to put back 3, I would question him/her. Keep in mind, 3 could mean more if any of them split. It is a risk to you and your baby(ies) and you could also have to make the incredibly difficult decision of selective reduction. Best of luck to you, whatever you do end up deciding.
    I suck at getting pregnant
    I really suck at staying pregnant
    image
  • I don't even have that option. My Dr will put back 2 max. They usually rec one but she is ok in my case of putting back 2.


    04/07/11- PCOS Diagnosis w/GYN. Put on Metformin (1500 mgs)
    04/25/11- 1st consultation with RE (Confirmed PCOS & Anovulation)
    05/09/11-HSG-All clear! 05/13/11-SA-Normal. Found out on 2/14/12, low Morph (1%).
    06/17/11-10 days of Clomid (100, 150) No response.
    07/10/11-03/20/12- 5 Injectable (Follistim) IUI cycles; 4 BFN, 1 C/P. (stims ranged from 11 days to 25 days)
    05/28/12-Diagnosed with Hypothyroidism. 75 mcg Synthroid.

    IVF with ICSI in June/July 2013 = BFP!. Beta # 1 = 123. Beta # 2 = 252. Due March 25th. Baby boy arrived March 27, 2013!

    FET #1 - 10/4/14 = BFP!! Beta #1 = 179. Beta # 2 = 499. Due June 22nd.

    Daisypath Anniversary tickers
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    image

  • imageEdwina.McDunnough:

    ASRM has ethical guidelines outlining the number of blasts to transfer, and 3 is reserved for those with a history of successful transfers and are at least 38 years old. If your RE is ethical, the option for 3 is poor, even with poor quality blasts, so it's not even something that you should be thinking all that hard about. Twins have the potential for a lot of problems as well. On this board I've seen so many complications from twins, I wouldn't take carrying multiples of any number lightly at all.

    www.asrm.org/publications/detail.aspx?id=3966

     

    I'd follow this - these guidelines are established for good reasons.  GL.

    Married 07.30.2011 TTC 07.2011 DX DOR 02.12 1st NC-IVF 03.12: RE could not retrieve egg 2nd NC-IVF 04.12: converted to IUI
  • imagege0rge:
    imageEdwina.McDunnough:

    ASRM has ethical guidelines outlining the number of blasts to transfer, and 3 is reserved for those with a history of successful transfers and are at least 38 years old. If your RE is ethical, the option for 3 is poor, even with poor quality blasts, so it's not even something that you should be thinking all that hard about. Twins have the potential for a lot of problems as well. On this board I've seen so many complications from twins, I wouldn't take carrying multiples of any number lightly at all.

    www.asrm.org/publications/detail.aspx?id=3966

     

    I'd follow this - these guidelines are established for good reasons.  GL.

     

    This exactly. I know you've been trying for a long time, but you just can't risk HOMs. I don't think I'd be comfortable with any more than 2. And 2 scare me b/c I know several ladies with twins that lost theirs in 2nd tri and a couple more that had their twins really early (29, 30 weeks) and that is a big burden to bear as well. 

    Best of luck to you. IF sucks!

    New to 3T? Check out this website first:
    TroubleTTC

    image
    Every new beginning comes from some other beginning's end --Semisonic

    **TTC since 04/09, C/P 02/02/10; 4 weeks, 3 days**
    **Dx: Anovulation, Hypothryroidism, Mild Endo, Pituitary Adenoma (prolactin issues), PAI-1, MFI **

    **7/10: Clomid + TI= BFN**
    **3/2/11: 1st RE appointment**
    **DH= Morph= 2%, Motility= 30%**
    **HSG= All clear!!**
    **3/11: Femara + Pregnyl + TI= BFN**
    **5/17/11: Laparoscopy / hysteroscopy = mild endo**
    **7/11: Novarel + IUI #1= BFN (7mil, 75% motility, 2% morph)**
    **8/11: Femara + Novarel + IUI #2= BFN (11mil, 35% motility, 1% morph)**
    **11/11: Femara + Novarel + IUI #3= BFN (9mil, 2% morph)**
    **Jan 2012: Follistim (75ius) + IUI #4= CANCELLED due to cyst -put on bcp**
    **Feb 2012: Follistim (75ius) + Novarel + IUI #4.2= BFFN (2.5mil, 13% motility, 1% morph)**
    **Mar 2012: Follistim (100ius) + IUI #5= CANCELLED due to 35mm & 14mm cysts**
    **On med break indefinitely...IF Sucks!**

    **Jan 2013: Follistim (100ius) + IUI #5.2= CANCELLED due to high prolactin level, MRI scheduled, pituitary adenoma found, put on Dostinex**
    **Mar 2013: Follistim (100ius) + IUI #5.3= CANCELLED due to uterine polyp, surgery scheduled for polypectomy and D&C**
    **03/22/13: Hysteroscopy, polypectomy and D&C**
    **May 2013: Finally got to start a cycle!!! Follistim (100ius) + IUI #5.4 = BFFN (6mil, 74% motility, 2% morph)** 

    **Jun 2013: Decide to start IVF**
    IVF w/ICSI #1 (Long Lupron Protocol)
    06/26/13: Start BCPs
    07/02/13: HSG #2= all clear
    07/15/13: Start Lupron 10 ius
    07/25/13: Suppression check
    07/28/13: Start stims (225IUs Follistim + 75IUs Menopur) drop to 5 IUs Lupron
    08/01/13: Monitoring: 12 follicles all about 10mm, E2- 313
    08/04/13: Monitoring: 18 follicles (15mm, 13mm, a few 11mm, rest 10mm or below) E2- 1,505
    Start Augmentin- antibiotic prep
    08/06/13: Monitoring: 13 follicles (18mm, 17mm, rest b/w 15mm-16mm!) Ready to trigger!! E2- 2,248
    08/08/13: ER-- 14R, 13M, 10F 
    08/11/13: One fertilized late, we now have 11 embryos!
    08/13/13: 5dt-- 2 blasts (Sheldon and Penny) 3AA and 3BB, none to freeze
    8/23/13: BFFN... Sheldon and Penny didn't stick**

    **8/29/13: Follow up... bad fragmentation issues. Changing protocol to Antagonist for round #2 coming soon! Also started on 81mg Aspirin after getting blood panel done and found out I have PAI-1**

    **Oct 2013: After large cysts, finally starting IVF #2**
    IVF w/ICSI #2 (Antagonist Protocol)
    BCPs started back in Sept due to cysts
    10/27/13: Start stims (225 IUs Gonal-F + 75 IUs Menopur)
    11/03/13 - 11/05/13: Add Ganirelix to the mix
    11/06/13: 3 follicles at 18mm-- Ready to trigger!
    11/08/13: ER-- 17R, 13M, 8F
    11/13/13: 5dt-- 2 blasts (Luke and Leia) 5AB and 4AB, 1 frostie
    11/20/13- 11/23/13: light positives on FRERs and Wondofos
    11/22/13: BFN per RE office (under HCG of 10)
    11/27/13: CP ::sigh::

    *12/03/13: Follow up...great response and quality this time, was given 50% chance of it working, just didn't stick. Great plan for 2014! 

    **Jan 2014: Last IVF of our SRP**
    IVF w/ICSI, freeze all, then FET
    12/27/13: Start BCPs
    01/19/14: Stims (375 IUs Gonal-F + 75 IUs Menopur)

    Congratulations Cutebride!! --TWINS!! Congratulations, Luvie, on your sweet boy! Congrats, Jess! So happy for you ladies! <3<3  
    ~~Also best of luck to Kati, illinigal, and youngin!~~

    *S/PAIFW*

    image
  • Thank you ladies. When I say I am ok with all 3 taking that is because I would be if thats what happened, But my bigger fear is that none will take. Which i why I ask opinions. We have had sooo many failed cycles with no reason behind them. Thank you all for your support and suggestions. I am going to wait and go with quality when the day comes. I will keep you all updated. I really just want the best for my baby, but I want there to be a baby for the best to be for. If that makes sense. 

    thank you all again, this has helped. I will research that page as well!

    Best of luck to you all!

     

    My Blog

    Me:26 PCOS, IR, MTHFR c677t/c677t, arcuate uterus DH:27 4% morphology
    11/2006 Married My DH
    Started trying on Honeymoon
    2009/2009 4 failed clomid cycles, many BFN, PCOS Study
    4/2010 5 rounds of femara resulted in BFP!
    6/2010 Lost our little poppy.
    7/2010 DX: MTHFR C677t/C677t
    2/23/2011 Starting first IUI cycle. Follistim and ovidrel. Fingers crossed...
    First IUI=BFN Second IUI=BFN
    9/2011: IUI 3,4,5,6 BFN
    1/2012 New year New plan... First consult for IVF.
    4/3/2012 First day of our 1st IVF cycle..
    5/16 ER 14R 6M 5F (25+ empty follicles)
    5/19 ET 3dt of 2 grade A 8 cell embabies!!! Stick baby stick
    8dp3dt BFP! Beta#1 12dp3dt 136, #2 14dpt 336, #3 16dpt 845
    6/19/2012 7w HB 131!!! 6/27/2012 8w HB 173
    Baby Delaney is scheduled to be induced Jan 30, 2013!!

    imageimageimageLilypie Pregnancy tickers
  • LaLe09LaLe09 member
    Believe me, I know the pain and desperation of wanting a child, but that's not a reason to put 3 embryos in on your first IVF (esp. being under 35). There are guidelines that are backed up by actual research data as Edwina pointed out. For under 35, the sET is being pushed by alot of clinics, the research shows that it has very similar pregnancy outcomes as a dET, without the increased morbidity and mortality of the mother and bab(ies). I would recommend doing alot more research on pregnancy/infant outcomes and not make a decision based on feelings. I know it's hard to separate the two with such an emotionally challenging situation. I hope you and your DH can come to a decision that is best for both of you! Good luck to you. I hope your cycle brings you success. :)

    DH: Severe MFI/Azoo Me: Compound heterozygous MTHFR
    IVF #1= m/c- methotrexate @6w2d
    FET #1= BFN
    IVF #2= m/c- D&C @8w5d
    IVF #3= Beta #1 9dp5dt= 252, Beta #2 11dp5dt= 417, Beta #3 17dp5dt= 4,952
    US #2 @ 7w2d= twins, baby B measuring behind
    US #3 @ 8w5d= Baby A doing well, no HR in baby B
    *S/PAIF always welcome* BabyFetus Ticker
  • My doc told me that with triplets there is a really good chance, besides all the complications a triplet pregnancy might have that that most triplets wind up with one baby that is very sickly because they just don't have enough room, or get enough oxygen in utero.
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  • I'm 43, so I would go for 3...but if I was younger, I'd NEVER go for more than 2 and honestly at 26, I'd just go for one - one has the best possiblity for success.  I'd freeze the rest. 
    image
  • I am currently on my first IVF cycle so I don't have much experience with this yet, but my RE said not to make any decisions on how many to transfer until we see the fertilized embryos and how they are doing. If they are really good then there is no point transferring more than is needed. They only transfer more when the quality is bad and they are hoping for one of them to stick. GL!
    Photobucket TTC since 1999. Unexplained Infertility. IUI#1 Oct. 12/11 - BFN IUI#2 - Nov 8 - Failed
    IUI#3 - Jan 6 IVF#1 -5/18 - stims start (225 gonal f, 75 menopur, 5 lupron) ER 5/29 - 14R, 11M, 7F. 6/1 - Transferred 2 8cell embryos (grade 1 and 2). 8dp3dt +HPT, Beta#1 - 92, Beta #2 - 174, Beta#3 - 614, Beta#4 - 2010. 6wk u/s - TWINS! Baby A 114bpm, Baby B 112 bpm Baby Birthday Ticker Ticker
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