Question for those w/ Success and MFI

schnena77 · April 2012

Me and DH are dealing with MFI. He is currently on clomid and supplements - but our main issue is morphlogy (1%). I took 50 mg clomid on IUI #1; 150 mg clomid on IUI #2 - both times only produced 1 dominant egg. DH's count and mortility were really good post wash (90Million; 91% Mortility - however when adding in morphology we are under 1 Million). Now moving onto IUI #3 - doctor wants us to continue w/ 150mg however based on the past 2 cycles I will only get 1 egg - so have been considering injectibles thinking if I can give more targets then might improve our chances. All in all what treatment finally worked for you? Should we just move onto IVF?

Thanks in advance for your input.

DH1972 · April 2012

I have problems with morphology too. We found out that I also have antibodies after the 3rd IUI, and after our 4th attempt we gave up and opted for IVF with ICSI. We felt that it was too emotionally draining to deal with one failure after another so we chose the option with the best chance of success. Unfortunately our first IVF attempt failed too, which was heartbreaking. We researched adoption and right before we submitted our paperwork we decided to give IVF one more try. I'm glad we did because now we have 2 baby girls.

KiKiGee · April 2012

We were DX both low count and low morph and advised to move right to IVF... which we did and IVF #1 brought us DS ...

I can't speak to IUI, clomid or anything because we skipped it all. Maybe get a second opinion just to see what someone else would recommend? While it felt kind of strange to "fast forward" I was also happy to get right to our best shot at having a baby ...

itsmevkb · April 2012

My husband has 0% morph and borderline count and motility. We've gotten pregnant without medical intervention, with clomid and timed intercourse, with IUI using femara and injectables and with IVF. So, just about every way possible.

Have you considered doing an hybrid cycle, using oral meds (clomid or femara) and adding in just a little bit of injectables? It's cheaper than doing a full-on injectables IUI and might get you an extra follicle without pushing you over into an area where you'd be uncomfortable going forward with the IUI (by having too many follicles).

ladychicago · April 2012

We were low count MFI...our post-wash IUI counts were as low as 800,000. We did three before moving onto IVF. And then IVF worked the first try, twice. Best of luck!!!

CJ71903 · April 2012

My husband had 0% morph and had varicocele surgery which only brought his morph up to 1% (all other parameters normal). Things checked out normal for me, and although our RE doesnt seem to think that morph alone would cause an issue, after three IUIs we were still unable to achieve a pregnancy. We did IVF and it worked and gave us our beautiful twins! Good luck!

jesselayne8 · April 2012

Our 3rd IUI worked. It was the first cycle with injects and I had 3-4 mature follicles. With my 4 clomid cycles I only had 1 follicle. DH's morph ranged from 1-2%. I think an injects cycle is worth a try before moving on to IVF.

gymnst1013 · April 2012

We have major morph and, to a lesser degree, count problems. We did 4 IUIs (the first one worked but ended in m/c) and the next 3 didn't. His numbers got progressively worse. We went to IVF with ICSI and had success on our first try. Good luck with your decision!

laura1 · April 2012

My DH had low normal count and motility but low morph (2-3%). The first time we got pg with our second clomid/IUI cycle, the second time was a complete surprise right after I weaned DS, and the third/fourth times (#3 was a m/c) were without any help either. I would give the injects a try before IVF - Good luck!!

JillRock96 · April 2012

We were low morph, count, and motility. We tried two IUIs with femara before moving on to IVF with ICSI. Good luck to you!

ETA: Oops, forgot to add that our doc was very against IUI with injectibles for me. I responded well to femara, and he was very concerned with the risk of higher order multiples if we were to do injectibles. But, I know this varies greatly person to person (and doctor to doctor).

pooman · April 2012

We were low count, low morph and low motility. My RE basically said she thought we should go straight to IVF. We did some medicated IUIs all BFNs. My second IVF gave us DD and I'm now pregnant with twins from our third fresh IVF.

Good luck with whatever you decide.

krissybegs · April 2012

My DH has 0% morph, but all other numbers are good. We opted to go straight to IVF with ICSI due to the better success rates and I was getting up there in age. IVF worked the first time and our little boy will be 4 in July.

Good luck!

esperanza123 · April 2012

I'm not a spring chicken (35.5 yo when DD was conceived) but my tests were all "normal" and our dx was low morph (between 2-4%). We did 3 IUIs and were successful with our first IVF with ICSI. Good luck to you!

Ali212 · April 2012

We had two issues -- my husband has low morph (but great numbers for everything else) and mine is unclear but appears to be egg quality related (can't really be diagnosed but based on how I reacted to IVF, that's what my REs suspect). We did 5 IUIs w/injectibles that were all failed cycles (for various reasons, a few were due to BFNs and most were due to cancelled cycles due to my hormone levels.

When I went for a consult with a new RE practice, they basically said (after looking at my files from my old practice) that they would never recommend IUIs for me given my husband's morph issues. The way my RE explained it was that they can't solve for the morph (or "shape") issue with an IUI and the shape issue is how sperm can inseminate an egg (obviously, I'm overly simplifying). He explained that with IVF and ICSI, they can "solve" for the shape issue by injecting the egg with the sperm. I did 4 IVF cycles (all with ICSI). The first 3 were BFN but my fertilization rates were over 90% so we knew then that MFI was not my only issue and than egg quality was also causing some fertility issues. My last IVF with ICSI was our 4th and only successful cycle. GL!

DrRx · April 2012

DH has low morph, count, and motility and I have PCOS. We did one round of IUI with Clomid and my RE advised against using injectables because of higher risk of high order multiples. She said that 1 shot at an IUI was worth a shot, but that after that she recommended IVF with ICSI. We got pregnant with our first IVF with ICSI (singleton but had transferred 2 day-5 embryos) and have 6 Day-5 embryos frozen.

Frankie · April 2012

MH has 0% morphology with low count and motility. We got pg with DD #1 on our first non-medicated IUI, and pg with DD #2 on our 5th IUI (but first using injectables; I never even tried Clomid since I didn't have ovulation problems, our main goal was to increase follicle count). BTW, DH's count has consistently been around 4-5 mil. GL!!

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