Infertility

**Updated** Assisted Hatching and Medrol

I ended up calling and my RE only prescribes the doxycycline.  Whew!!  I feel so much better.

Thanks for all the advise and experiences!

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For our IVF cycle we are doing ICSI and assisted hatching based on my age...

I was given an rx for the antibiotic doxycycline but wasn't given a script for medrol which I've read is standard for assisted hatching.  Now I'm freaking out as this steroid is thought to possibly decrease the chance of an antibody/immune response to your embryos.

I would need to be on 16mg for 5 days.  

Should I call the emergency line and ask the doctor on call or just wait and call in the morning?  It's still early enough that if needed I could get the script tonight.

Totally freaking!!

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06.10.12 +HPT 06.12.12 Beta #1 = 2,770 06.14.12 Beta #2 = 6,300
1st U/S 06.18.12 2nd U/S 06.25.12
09.24.12 It's a Boy!! ---> Jacob Owen

Our IF Journey Began: October 2009
**8 Failed IUI's, 1 Blighted Ovum, & 1 Failed IVF**
Dx: MFI, DOR w/MTHFR Homozygous A1298C & Hypothyroidism
03.2012 Lab Results: FSH 6.83 AMH 0.67 TSH 3.8 E2 17
SA 156 million 93% motility 3% morphology

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Re: **Updated** Assisted Hatching and Medrol

  • I'm not sure how imperative the timing of medrol doses is in relation to AH.  Just for your reference (or, possibly, more frustration...I apologize), the medrol is standard at my clinic -- I had to take it even without AH.  Just checked my notes and I started it the evening of my ER -- same dosage and duration as you.

    I think that any amount of freaking out/uncertainty while cycling -- especially when it comes to meds -- certainly warrants a call to the doc on call.  They field all sorts of calls, so I wouldn't worry at all about doing so.  Your peace of mind is totally worth it! 

    [Edited to change ET to ER!] 

    TTC since honeymoon in 9/2010
    Me: 39, Dx DOR (FSH = 10.5, AMH = 0.43, best AFC = 10), AMA
    MH: 37, Dx Obstructive Azoospermia, multiple successful sperm retrieval procedures

    1/2012: IVF/ICSI #1 Antagonist = cancelled d/t poor response to max stims
    2/2012: IVF/ICSI #2 MDLF (4R, 4M, 1F) = BFP, saw heartbeat, missed m/c 9w0d, D&E
    8/2012: IVF/ICSI #3 EPP/MDLF (7R, 2M, 1F) = BFN

    12/2012: (New RE) Operative hysteroscopy to remove scar tissue

    1/2013: IVF/ICSI #4 Low-dose stim/Antagonist (AFC=6); ER=1/26 (5R-couldn't access rt ovary, 5M, 4F), ET=1/29 (trans 3) = BFP!; 2/11 beta#1(13dp3dt)=2127, 2/13=3367; twin girls due 10/19/13

    PAIF/SAIF very welcome!

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  • I would call.  Medrol is standard with or without AH at my clinic.  I did ICSI with AH.  I had to start it the day of ER. 
    I had trouble with my pharmacy not sending it with my meds.  I had to have my IVF nurse call it in locally. 
  • Dexamethasone (very close to Medrol) is standard at my clinic. I am starting it earlier than most since I have some issues, but I am pretty sure it is part of everyone's protocol. My understanding is that this drug is more associated with the docs that believe in immune issues, so I am just not sure that every place would use it. I am new to this though and just starting this whole process, but that's what I've learned through my endless hours of Dr. Googling.

    If you are worried, you should call. That's what they are there for, and if there is a reason they don't want you on it, they can explain that too.  

    Good luck, and keep us posted. 

     

    ttc since 2/2010 ~
    me (36): Hypothyroid (on Levothroid), low vit. d, borderline/high fsh (day 3: between 7-10) (day 10: 13 during CCCT), AFC: 14
    dh (31): awesome (minus one sample with agglutination)
    Diagnosis:possible DOR and/or unexplained + elevated NK cells + MTHFR (C677T - one copy)

    MAY 2011 - FEB 2012 - 3 injectable IUI's with numerous cancellations due to high TSH levels
    MAY 2012 - onto IVF/ICSI (Antagonist Protocol) on BCP and Folgard (3 week delay - cyst - boooo) 5/21 start stims 5/30 ER 11R 8M 3F 6/2 3DT of 3 6/12 Beta #1 83 | 6/14 Beta #2 196 | 6/21 Beta #3 3818 | 6/28 Beta #4 22,213 | 7/2 1st U/S - 2 on board! 8/24 CVS reveals that we have a boy AND a girl on board!

    Healthy baby boy and girl born in February, 2013 at 38 weeks and 2 days!


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  • Medrol is part of my protocol.  I would give a call.  With all the money that you're paying, use the resources and don't take a chance.

    3 ectopic pregnancies (EDD's 1/30/12-tube removed, 6/2/12-methotrexate and 10/2/12-methotrexate)
    IVF and Natural FET resulted in BFN's and a hole in our wallets
    Natural BFP #4 on 9/7/12 gave us our miracle on 5/18/13
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    We did AH with our successful cycle and I never took Medrol or Doxy. I remember being worried, but my RE said it wasn't needed. GL!  

    ETA: I forgot to mention, I have a diagnosed autoimmune disease, so I was totally freaked about not being on Medrol. But, my RE isn't big into immunology, so I imagine that impacted things.  

    TTC in 2009, Dx: Unexplained IF
    Three TI cycles (BFP...miscarriage), five IUI attempts and 2.5 IVF cycles later...BFP!!
    12dp5dt: 765; 15dp5dt: 1979; 17dp5dt: 3379...TWINS!!!!!
    Our perfect baby boys were born at 36w1d!! 








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