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September 2012 Moms
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Can you develop a tolerance to Zofran?

IBackBevoIBackBevo member
in September 2012 Moms
I've noticed that my nausea has been getting worse lately and the Zo doesn't seem to be helping.  At first, it would completely alleviate all symptoms, but now I'm still left dry heaving, gagging and generally feeling nauseated...just without the throwing up.
IF DX: DOR & Fragile X pre-mutation carrier
2011: FSH 13.3 & E 99; AMH 0.54 2nd FSH 6.2 E 40's AFC: 8
BFP from Clomid/IUI ~ Pre-e and IUGR during pregnancy ~ DS born 9/4/12
Feb./March 2013: AMH less than 0.16 (undectable) and AFC = 4;
BFP from supps ~ DS#2 due May 2014

May 2014 January Siggy Challenge:
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Re: Can you develop a tolerance to Zofran?

  • TartaTarta
    I think so. This has happened to lots of others. I sometimes wonder if it's happened to me. You might need to increase your dosage or try a different anti-nausea med. Also, at this point I'm noticing my nausea seems to be more reflux induced. It's a sour acidy feeling nausea. So now I'm going to talk to my MW about controlling the acid and see if that helps.
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  • terri_doula2010terri_doula2010 member
    Yes. Or your nausea can just get worse and you can need more zofran to maintain. 4mg once or twice a day was enough at first, then I had to go up to 8mg once or twice a day. Now mine is at least heartburn related, so now I'm back down to 4mg once a day along with 24 hr prilosec.
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  • roxyttandmeroxyttandme member

    imageterri_doula2010:
    Yes. Or your nausea can just get worse and you can need more zofran to maintain. 4mg once or twice a day was enough at first, then I had to go up to 8mg once or twice a day. Now mine is at least heartburn related, so now I'm back down to 4mg once a day along with 24 hr prilosec.

    Mine as doubled last week too.... Wasn't working for me. I am still sick at times also...

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  • IBackBevoIBackBevo member
    Thanks for the replies.  I think mine is somewhat indigestion related.  Have you guys found anything that helps?  I took some ranitidine and tums, which are both supposed to be safe, but they don't seem to help.
    IF DX: DOR & Fragile X pre-mutation carrier
    2011: FSH 13.3 & E 99; AMH 0.54 2nd FSH 6.2 E 40's AFC: 8
    BFP from Clomid/IUI ~ Pre-e and IUGR during pregnancy ~ DS born 9/4/12
    Feb./March 2013: AMH less than 0.16 (undectable) and AFC = 4;
    BFP from supps ~ DS#2 due May 2014

    May 2014 January Siggy Challenge:
    image
    image
    Report Reply
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