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MTHFR gene question

atprincatprinc
in High-Risk Pregnancy

Hi! I need some advice and I though some of you might be able to give me some insight.  I had a pretty scary experience with my first child almost 4 years ago- Meg was born at 35 weeks b/c of oligiohydraminos (no fluid) with IGUR and, I recall my OB saying, a large blood clot of my side of the placenta. When I asked my OB about this last summer, she offered blood work and found that I am homozygous dominant (2 faulty copies) for the MTHFR gene. When I got pregnant last July, my OB suggested Folgard- an over the counter version. I miscarried that pregnancy and can't help thinking that I wasn't aggressive enough with making sure my condition was monitered. DH and I have gotten to the point that we are ready to try again, but I almost don't feel like my OB is proactive enough... not that I want Lovenox right away, but I would like to be more proactive- our loss was devestating.

 Has anyone had a similar experience? Any advice?

Happily Married since 10-31-03 Meaghan Riley Grace arrived 1 month early- May 19, 2008 Angel Baby- lost on September 12, 2011- 8 weeks Hoping for a sticky baby!
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Re: MTHFR gene question

  • monica92603monica92603 member
    Ask your OB to have your homocysteine levels checked.  With as much indecisivemess as there is regarding MTHFR, I do believe there is some agreement that if you have high homocysteine levels, you have a higher risk of clotting.
    I have one copy of C677t.  I'm on baby aspirin and 1mg of folic acid just as precautionary.  Do you know which gene you are homozygous for?  Either is manageable, there are several ladies on PgAL who have one or the other and have had healthy pregnancies, just closely managed.
    Good luck and I'm very sorry about your loss.
    BFP #1 5/10/06 ...m/mc @11.5w 6/29/06 D&C 6/30/06
    BFP #2 10/29/08 ...stillborn via c/s @41w 7/20/09
    Lilypie Angel and Memorial tickers
    missing my baby everyday
    BFP #3 1/20/10 My angel's little sister Grace Madison was born September 8th 2010 @37w. We're so blessed! Thank you angel for getting her here safely.
    BFP #4 12/30/11. Jackson Christopher 8/22/2012 via repeat c/s @ 37w 3d
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  • gringa78gringa78
    I'm so sorry for your loss.  I only have one copy of MTHFR and I have no history of clotting but I have been on Lovenox for both of my pregnancies.  In my mind, I've never been concerned if it is overkill or not...better safe than sorry, IMO.  I would push the issue if I were you.  Folguard alone will only help with folic acid depletion - not clotting.  Good luck!
    PCOS, lupus anticoagulant, MTHFR (A1298C, one copy) 2 IUIs & 1 IVF = BFN FET#1 = It's a girl! Born 7.1.10 FET#2 = c/p FET#3 = Twin girls! Born on 3.16.12 at 33w2d due to severe pre-E. After 4 weeks in the NICU they are home! Lilypie Third Birthday tickers
    Lilypie Premature Baby tickers
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  • smacbsmacb

    I have two mutations.  I've had seven miscarriages.  When I was first diagnosed, they had me on baby aspirin, folgard and Lovenox.  I miscarried on those.  They switched me to Lovenox and Folgard.  So far so good with this pregnancy.  My RE wasn't convinced that all of my miscarriages were from MTHFR.  While some probably were, some were probably related to my thyroid disease and my RE thought some were related to poor egg.sperm quality.  My MFM said that I had one if the least severe mutations and that for me the Lovenox was largely precautionary.

    My best advice is to ask your doctor a lot of questions, insist on whatever test you need, educate yourself and ask to be referred to specialists if you think it's necessary.

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  • Holly THHolly TH

    A,

    You might want to ask your doctor about L-methylfolate.  If I understand correctly, you are homozygous for the MTHFR polymorphism.  This is the most severe form and you have a very limited ability to break down synthetic folic acid.  I work with NeevoDHA, a prenatal specifically indicated for women with the MTHFR polymorphism.  It contains active L-methylofolate as an alternative to synthetic folic acid (found in Folgard).  L-methylfolate is 7 times more bioavailable than folic acid and bypasses the MTHFR mutation.  It is something simple and safe you can do to make sure MTHFR-related folate deficiency is not an issue while trying to conceive and during pregnancy.  

    With your history, I can certainly understand why you are fearful.  There are many women who have your mutation and your history who are on Lovenox as well.  I am so sorry for your loss and I hope you and your doctor are able to come up with a plan that results in a healthy, uncomplicated pregnancy in the near future.  Best of luck!

    Married to DH - 1996 DS - 13, DD - 11, DD - 9, DS - 4
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  • Baby BouchardBaby Bouchard member

    I am about 6.5 weeks pregnant and just found out about my MTHFR homo status due to a recent loss in November. OB has me on baby aspirin, heparin and Neevo as well as progesterone because on top of my status I also seem to have low progesterone this pregnancy.

    We actually have an appointment tomorrow, all the meds were done by phone once my results were back in and she knew I had also just found out I was pregnant. So far so good.

    You have to be your advocate, if you feel like you want to take those medications then ask. My previous OB didn't even bring up the testing, even though things pointed to it. So happy we have this new OB. Keep us updated!

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  • Holly THHolly TH

    Baby Bouchard,

    Have you had more than one loss?  

    Married to DH - 1996 DS - 13, DD - 11, DD - 9, DS - 4
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