IVF cycle cancelled -- poor response to max dose
joules12
member
Thanks again for all the kind words in response to my prior post (re: my cycle almost being cancelled on Sunday). Went in for another monitoring appointment this morning and just heard from my RE. My E2 has increased a bit, but so has my LH...apparently, my body is ready to get the show on the road. My two lone measurable follies didn't really change much between yesterday and today, so they've decided to cancel my cycle.
RE mentioned doing the MDLF protocol next. He's looking into whether EPP is a viable option to be combined with that (although he usually only uses it with an antagonist, as I think is the standard use). He also recommended that I start on 75mg of DHEA...getting that on my way home this evening.
I'm certainly frustrated and sad, but more so because I'm concerned abouth whether things will actually change on a different protocol/month. Beyond that, I was actually more miserable over the weekend, when I didn't know how things would play out and it really felt like I was stuck on a roller coaster.
Looking very forward to some wine and sushi this evening. I won't miss doing the self-injections, even though I've gotten into a routine with them. With my cat at the vet for a second night of observation and IV fluids/antibiotics (still waiting on some additional blood test results), I will also very much welcome a break from the added hormone insanity.
As long as I stay in fairly good spirits, I'll be sticking around here during my downtime -- I've got too many fingers and toes crossed for everyone to disappear anytime soon. Really, really hoping to hear lots of great news from others in the coming days!!!
Me: 39, Dx DOR (FSH = 10.5, AMH = 0.43, best AFC = 10), AMA
MH: 37, Dx Obstructive Azoospermia, multiple successful sperm retrieval procedures
2/2012: IVF/ICSI #2 MDLF (4R, 4M, 1F) = BFP, saw heartbeat, missed m/c 9w0d, D&E
8/2012: IVF/ICSI #3 EPP/MDLF (7R, 2M, 1F) = BFN
12/2012: (New RE) Operative hysteroscopy to remove scar tissue
1/2013: IVF/ICSI #4 Low-dose stim/Antagonist (AFC=6); ER=1/26 (5R-couldn't access rt ovary, 5M, 4F), ET=1/29 (trans 3) = BFP!; 2/11 beta#1(13dp3dt)=2127, 2/13=3367; twin girls due 10/19/13
PAIF/SAIF very welcome!
<a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Pregnancy"><img src="http://global.thebump.com/tickers/tt16bf7d.aspx" alt=" BabyFruit Ticker" border="0" /></a>
Re: IVF cycle cancelled -- poor response to max dose
So sorry Joules. I know too well how hard it is to be cancelled. On our second try, we radically changed the protocol, added HGH and I had a much better response. It sucks because we all want it to work the first time. While it does for some, for the vast majority it seems like cycle 1 is a learning experience. You'll regroup and get a new plan in place for next time. Sounds like your RE is already on top of things.
Hope your kitty improves fast. For now, wine and sushi sound like a great plan!
Baby boy Henry born 2015.
Expecting our capstone baby (boy) early March 2018.
DH diagnosed with Testicular Cancer 8/2010
Low sperm count. Only option IVF with ICSI
Starting First cycle Jan/Feb 2012- Canceled due to not responding to BCP and/or Lupron
IVF 1.2- stims March 14, ER March 24, 16 R 10F 6 made it to blast
ET March 29- transferred two blasts, 4A and 4BA, froze 4
Positive HPT 9dp5dt Beta 1- 385 11dp5dt
u/s April 25- one healthy heartbeat
EDD 12/12/12>
I'm so sorry Joules
I really hope you enjoy your wine and sushi whole heartedly, and your kitty comes home healthy and happy!!
And finally, I am praying that your future protocol brings you the BFP and take home baby you want!! (hugs to you and your sweet kitteh!!)
DX: 6/9/2011: Azoo ICSI/IVF only option for biological child
IVF #1: ER - 9/26 * ET - 10/1 * beta#1 10/13 - 140 * beta#2 10/17 - 477 * beta#3 10/20 - 1101
1st u/s at 6w6d - one hb * 2nd u/s at 8w3d - no hb detected 11/10/11 * natural m/c 11/13/11
FET #1 Jan/Feb 2012 - 3 delays - cancelled 2/13
FET #1.2 - May/June 2012 - ET 6/6/* beta#1 6/15 - 95 * beta #2 6/19 - 322 * beta #3 6/22 - 940
7/6 1st u/s @ 7 weeks - one beautiful hb - released from RE
EDD 2/22/2013
PAIF/SAIF/PGAL welcome
Dx: DH - Azoo, Me - Mild PCOS
DH - sperm found! Seems to produce only for a few days every 70 days!
Over 1 million in cryo in 15 vials over 6 samples
IVF #1 - 1 beautiful expanded blast transferred, 4 snowbabies - beta #1 11/30/11 = BFFN
FET #1, transfered 2 embies 2/16/12 = BFFN; 1 snowbaby left in cryo
IVF #2 + CGH = 4 genetically normal embies on ice. FET September 26th
SAIF/PAIF always welcome
a special GL and prayers to my IF sister Gregermis
check out my blog!
::: Married June 2003:::
TTC #1 since: Aug. 2008
Me: 34, DOR, MTHFR-A1298C (heterozygous), decreased blood flow to uterus, Mild Endo
DH: 38, Balanced translocation 5&10, unexplained MFI, normal SA and SCSA
Tx History: IUI 1&2= BFN
IVF# 1 W/ICSI= BFN
IVF# 2: cancelled d/t no response
IVF# 3= 1 egg retrieved=immature/not viable
IVF# 4= c/p
***CCRM ODWU***
Found DHs BT and Me-decreased blood flow to uterus
Recommended DE IVF w/PGD, incorporate electro-acupuncture. Decided to cycle locally
***New RE***
DE IVF# 1(cycle #6) w/pgd, (freeze all): 30R, 23M, 15F, slow/poor embryo development, 4 biopsied, 1 Normal "Norm"; DE IVF w/PGD, incorporate electro-acupuncture.
IVF# 6: (OE/DS) cancelled
IVF# 7: (OE/DS) 1R, 1M, 1F, arrested day 5
Plan-DE IVF# 2 (cycle #8): DE/DS in May 2015
http://icanhazbabyz.blogspot.com/
Oh Joules, I'm so sorry! Being cancelled really stings. I also had a dismal response to an antagonist cycle and remember the feeling of relief/grief that came with the final cancellation. But, I think there is every reason to hope a new protocol can make all the difference. It sounds like your RE is really taking the time to customize a new protocol just for you.
When my RE called to cancel the cycle, he told me to make myself a big drink that night. So, I say take out the good bottle of wine and some fabulous sushi! It's doctor approved! Sending you a GIANT hug!
12dp5dt: 765; 15dp5dt: 1979; 17dp5dt: 3379...TWINS!!!!!
Our perfect baby boys were born at 36w1d!!
TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46
DOR (FSH 24.3)/ terrible egg quality ; homozygous MTHFR c677t
5 IUI's: 2/11 to 6/11 and 1/12= BFN
OE IVF#1-4 8/11-6/12= all BFN
DE IVF#1 11/12 bad embryos= BFN
DE IVF #2 2/13 BFP/Beta hell: m/c 5w6d
CFNBC 7 months, not doing well; decided on guarantee program at RBA w/frozen DE
DE IVF #3 1/14 ET 4BB; BFP;M/C 5w1d, incomplete m/c; MVA extraction in ER 7w1d
DE FET#1 ET 3/1714; BFP, beta 1 3/27= 197, beta 2 3/31= 1586, beta 3 4/7= 13879!!
First u/s= Twins with HBs at 6w2d! We are Team Pink x 2!!
K & K born 11/21/14 at 38wks 4 days
SAIF/PAIF Welcome
http://waitingforraintostop.wordpress.com
3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
Multiple ectopics, 2 failed IVF's
IVF #1: Did not get to ET, embies all failed PGD (major chromosomal defects)
IVF #2: We have 2 chromosomally perfect embies as a result of PGD (Boy/Girl) 1 failed the thaw (Girl) Transferred 1, yet ended as a c/p
Thought it was the end of our TTC Journey 6/20/2012
SHOCK BFP 9/28/2012: IT'S A BOY! and everything is normal !!!!!!
Little A born 38w 2d on 05/23/13 and is a true miracle for this IF Vet!
I wish you didn't have to face disappointment so early on, but the bright side is it sounds like your doctors are looking into things and are working with you instead of having you go through cookie cutter treatment.
It's good you are holding onto the hope that things might be different next time, because chances are they will be.
Take time for yourself and enjoy those little luxuries, like wine and sushi!
TTC since September 2009.
IVF #2: +HPT 2/6/12! ~ Boy/Girl Twins!!
I'm so sorry you were canceled. It really sucks.
I had a much better response with MDLF and had 8 mature eggs retrieved. When I had my WTF, they said they may consider doing a EPP in addition next time. So I'm thinking that is a viable option for you.
Hugs, and enjoy your injection free evening.
Me: 39, Dx DOR (FSH = 10.5, AMH = 0.43, best AFC = 10), AMA
MH: 37, Dx Obstructive Azoospermia, multiple successful sperm retrieval procedures
2/2012: IVF/ICSI #2 MDLF (4R, 4M, 1F) = BFP, saw heartbeat, missed m/c 9w0d, D&E
8/2012: IVF/ICSI #3 EPP/MDLF (7R, 2M, 1F) = BFN
12/2012: (New RE) Operative hysteroscopy to remove scar tissue
1/2013: IVF/ICSI #4 Low-dose stim/Antagonist (AFC=6); ER=1/26 (5R-couldn't access rt ovary, 5M, 4F), ET=1/29 (trans 3) = BFP!; 2/11 beta#1(13dp3dt)=2127, 2/13=3367; twin girls due 10/19/13
PAIF/SAIF very welcome!
<a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Pregnancy"><img src="http://global.thebump.com/tickers/tt16bf7d.aspx" alt=" BabyFruit Ticker" border="0" /></a>