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Anyone really understand the embryology side of IVF re: grading?

ksteeb611ksteeb611 member
in Success after IF

We had 27 eggs fertilized and froze them 'til our FET 1/22.  On 1/22, the Dr and embryologist told us we have two beautiful looking Grade 1 (best) 8-cell embryos, which we transferred that day.  The other two embryos taken out became a Grade 2 9-cell and a Grade 2 6-cell.  They were growing these out to blastocysts and would refreeze them if they looked good.  When the embryologist called yesterday, she said one of them died and one became a blastocyst, but probably wouldn't survive another freeze.  Does this say anything about the ones were transferred surviving?  They were Grade 1s, but I'm still concerned.  TIA!

March 2011: Off Nuva, cycle back to "normal" for me: No periods since 15 years old. June 2011:Provera&50 mg Clomid; Progesterone:0.7 July 2011:Provera&100mg Clomid; Progesterone:3.29 Met with RE:No Clomid response, begin injectables Sep 5 mg Letrozole and Ovidrel in the interim month. Cut out running (was a distance-runner), cycling, eliptical. Restricted to weight-training, walking, pilates. Brain MRI normal. Being physically over-stressed is the reason the body stopped producing prog. Late Sep 2011: Menopur, Ovidrel,& IUI (10.10.11):BFN-Great injectable response: 2 mature, 6 near mature, many smaller; Problem: 9 cysts! Dr: IUI too uncontrolled for number of viable eggs & age. On to IVF! IVF ER 12.6: 37 mature eggs, 27 fertilized, froze all to avoid overstimulation; FET 1.22 (2 Grade 1)=BFN; FET 2.22 (3 Grade 2)=BFP! Beta 10dp3dt=291; 12dp3dt=644; HB 3.26!! 174 bpm: Vanishing twin almost completely absorbed 10wks Baby Birthday Ticker Ticker
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Re: Anyone really understand the embryology side of IVF re: grading?

  • LVBlvdLVBlvd

    I don't think that would speak too much of the ones you transferred.  That sounds like the natural progression of IVF - many retrieved, less fertilized, less than what is fertilized starts to divide, less than what starts to divide makes it to day 3, less than that makes it to blast, and even less than that makes it to freeze.

    Plenty of people have success with only 1 or 2 embies making it that far and have none to freeze.  My daughter is an example of that!

    Best of luck to you - your cycle sounds promising and I hope to see your BFP announcement soon! 

    DX: PCOS * Success with IVF

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  • beebe929beebe929 member

    They say the best 8 cell ones are most likely to survive, it is your best shot. I have heard of failure in 8 cells, and in my case we had much worse quality and slow development, but I had 1 survive in both IVFs with my daughters.  I also feel that your uterus is the best place for them, others may disagree.

     

    Good luck!!

     

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  • LALASEPT05LALASEPT05 member
    Absolutely not. I think some times doctors are very selective about what freezes and I think that a lot of times the embies do better back in our bodies than they do in a man made lab. We had 3 very good quality embies. We transferred 2 and chose to try and freeze the remaining. It did not make it to freeze and I also worried that the two we transferred would not take. They both did! Good luck!
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  • AvaLikeLavaAvaLikeLava member

    Nah, I like to think of it as school progression. If you have one kid that gets a D on a test, it doesn't reason that your second will also get a D on the same test ;)

    I know I'm over-simplifying things, but if there was a general egg quality issue, you wouldn't as a whole have these Grade 1s and 2s.

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  • ksteeb611ksteeb611 member
    Thanks so much for your upbeat and reassuring response!
    March 2011: Off Nuva, cycle back to "normal" for me: No periods since 15 years old. June 2011:Provera&50 mg Clomid; Progesterone:0.7 July 2011:Provera&100mg Clomid; Progesterone:3.29 Met with RE:No Clomid response, begin injectables Sep 5 mg Letrozole and Ovidrel in the interim month. Cut out running (was a distance-runner), cycling, eliptical. Restricted to weight-training, walking, pilates. Brain MRI normal. Being physically over-stressed is the reason the body stopped producing prog. Late Sep 2011: Menopur, Ovidrel,& IUI (10.10.11):BFN-Great injectable response: 2 mature, 6 near mature, many smaller; Problem: 9 cysts! Dr: IUI too uncontrolled for number of viable eggs & age. On to IVF! IVF ER 12.6: 37 mature eggs, 27 fertilized, froze all to avoid overstimulation; FET 1.22 (2 Grade 1)=BFN; FET 2.22 (3 Grade 2)=BFP! Beta 10dp3dt=291; 12dp3dt=644; HB 3.26!! 174 bpm: Vanishing twin almost completely absorbed 10wks Baby Birthday Ticker Ticker
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  • ksteeb611ksteeb611 member
    Amazingly cute photo!
    March 2011: Off Nuva, cycle back to "normal" for me: No periods since 15 years old. June 2011:Provera&50 mg Clomid; Progesterone:0.7 July 2011:Provera&100mg Clomid; Progesterone:3.29 Met with RE:No Clomid response, begin injectables Sep 5 mg Letrozole and Ovidrel in the interim month. Cut out running (was a distance-runner), cycling, eliptical. Restricted to weight-training, walking, pilates. Brain MRI normal. Being physically over-stressed is the reason the body stopped producing prog. Late Sep 2011: Menopur, Ovidrel,& IUI (10.10.11):BFN-Great injectable response: 2 mature, 6 near mature, many smaller; Problem: 9 cysts! Dr: IUI too uncontrolled for number of viable eggs & age. On to IVF! IVF ER 12.6: 37 mature eggs, 27 fertilized, froze all to avoid overstimulation; FET 1.22 (2 Grade 1)=BFN; FET 2.22 (3 Grade 2)=BFP! Beta 10dp3dt=291; 12dp3dt=644; HB 3.26!! 174 bpm: Vanishing twin almost completely absorbed 10wks Baby Birthday Ticker Ticker
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  • ksteeb611ksteeb611 member
    Congrats to you!!  Thanks!
    March 2011: Off Nuva, cycle back to "normal" for me: No periods since 15 years old. June 2011:Provera&50 mg Clomid; Progesterone:0.7 July 2011:Provera&100mg Clomid; Progesterone:3.29 Met with RE:No Clomid response, begin injectables Sep 5 mg Letrozole and Ovidrel in the interim month. Cut out running (was a distance-runner), cycling, eliptical. Restricted to weight-training, walking, pilates. Brain MRI normal. Being physically over-stressed is the reason the body stopped producing prog. Late Sep 2011: Menopur, Ovidrel,& IUI (10.10.11):BFN-Great injectable response: 2 mature, 6 near mature, many smaller; Problem: 9 cysts! Dr: IUI too uncontrolled for number of viable eggs & age. On to IVF! IVF ER 12.6: 37 mature eggs, 27 fertilized, froze all to avoid overstimulation; FET 1.22 (2 Grade 1)=BFN; FET 2.22 (3 Grade 2)=BFP! Beta 10dp3dt=291; 12dp3dt=644; HB 3.26!! 174 bpm: Vanishing twin almost completely absorbed 10wks Baby Birthday Ticker Ticker
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  • JGirl2005JGirl2005 member
    Your numbers are quite normal.  Remember even not best embryos become beautiful babies...don't worry about the ones you have in you.  Keep thinking positive!
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