I also posted this on IF, but I found it too good not to share.
I just watched this video (it's nearly an hour), but oh my is it fascinating and very much worth viewing.
https://www.documentary24.com/the-gost-in-our-genes-science-of-genetics--173/
The premise is that certain genes can be switched on and off at different times depending on gender. Furthermore it details things our grandparents and great-grand parents experienced may switch on genes for us.
If they lived through famine, stressful periods like war, or were exposed to toxic chemicals, it can switch genes to affect us and may even be a factor in diseases. This could explain why people who live healthily and don't smoke can get cancer.
They discuss IVF and infertility to some extent, but the whole premise is really fascinating.
There were a couple interesting articles I found pertaining to MFI particularly, since that is our diagnosis. It looks like genes may be mitochondrial associations, passed from mothers to sons (so you really may have something to dislike your MIL for!) ![]()
https://www.sciencedaily.com/releases/2007/12/071212202006.htm
https://www.sciencedaily.com/releases/2011/05/110513112258.htm
I'm excited to read more about this and hopefully it will lead to some better understanding of how to fix IF.
Re: xp: epigenetics
Thanks for sharing this! Epigenetics is part of what I deal with at work, so I am always interested to see how it's being used for IF. I'm currently reading the book Origins, and it discusses quite a lot of this same material, just in a less science-y way. The whole topic is really cool, IMO
Me = lean PCOS;DH = poor morphology (3%)
3 IUI/TI cycles = BFN
IVF #1 with ICSI: antagonist protocol = BFFN
IVF #2 with ICSI : Lupron downregulation = BFFN...FML
IVF #3 with ICSI and AH (Antagonist) = IT'S A BOY!!!!
I think it's super cool too. It really makes sense when you think about it, but now I am curious what the heck our families were doing way back when.
It also makes you nervous for the drugs people do now days, like meth, etc. I'm thinking fertility rates are only going to continue to decrease and it might be why super rural areas always seem to have higher fertility rates, too.
ETA: I just ordered the book! Yay, Amazon for shipping to me over here.