Zofran vs Phenergan

gervaisj6 · November 2011

I went to my ob today. She gave me a prescription for both. I have not had any morning sickness (knock on wood). But I got them both filled, just in case. The Dr. Told me Zofran can make you constipated, and Phenergan can make you sleepy. I teach, would Zofran be better to take during the day? Does it make you drowsy? Any thoughts on zofran vs phenergan?

samanthadaniel · November 2011

Pharmacist said the same thing to me about Z and P, I tried the P one morning and I didn't have any drowsiness but it may affect you differently. Both work beautifully for me but my insurace would only let me have a minimal amout of the Z so I've been working with the P mostly.

TerraCotta210 · November 2011

Unfortunately, I cannot give you any advice on Phenergan, but I can tell you that while Zofran is my miracle medication, it does in fact make you extremely constipated (or this is what happened to me at least). Within about 36 hours after starting the medication I was already horribly constipated. Now, I take a regular cocktail of Metamucil and Fibercon to keep regular. I find that if I miss even a single dose I start to have problems again.

If you are worried about getting sleepy (I would be worried as well), I would suggest starting a fiber regimen as soon as you start the Zofran - hopefully this will prevent you from ever getting constipated in the first place. Not to mention, my OB says there is no harm in taking the extra fiber anyway.

jp0129 · November 2011

I have both and honestly the Zofran did nothing for me. The Phenergan knocks me out. I take it about 30 min before I go to bed and I wake up feeling good.

Jess & Drew · November 2011

Zofran didn't make me sleepy although I'm sure there are some exceptions. But my experience with Phenergran is that it makes most everyone a little more than sleepy. It will completely knock you out.

MelissaFSU · November 2011

I've had no experience with Z, but I take half of a 25mg phenergan as needed and it works great for me. I don't feel drowsy (any more than the fatigue gives me) and I've had no contipation with it so it gets major points from me.

charmschool · November 2011

I have taken both and my experience is that Phenergan is way more effective, but Zofran is better to take on a day to day basis, when you have to continue your normal routine. Phenergan works so well, but it makes you SO sleepy! I only take it on the really miserable days when I just really can't keep anything down and have to take the day off and sleep all day.

colleen724 · November 2011

I only took zofran, it did make me horribly constipated. can I ask why at nearly twelve weeks they gave you a prescription for something you dont have...

gervaisj6 · November 2011

colleen724:
I only took zofran, it did make me horribly constipated. can I ask why at nearly twelve weeks they gave you a prescription for something you dont have...

It was in a bag of stuff, the prescription was even stamped on the doctor's pad...I think it is standard there... that everyone gets one... lol

This was my first visit with my ob today. I have been under the are of an RE since last year. and I don't think I will have m/s but I don't wanna need it and not have it...

sweetsugarmama · November 2011

Phenegran knocked me out. I couldn't keep my eyes open. I take half a unisom tablet and b6 at night which is comparable to phenegran in some ways, it keeps me throwing up less in the morning (still sick though). I take Zofran daily and haven't had any of the constipation problems from it. It didn't affect anything with DD like that. I did have some constipation issues previously with this pg so I take colace nightly.

allisonmarie22 · November 2011

The P is super cheap. I would try that first. If it makes you sleepy and you decide to go with the Z then you're not out a lot of $$.

LadyTyler · November 2011

I got Phenergan when I had a really bad flu and it worked pretty well but it made me extremely tired--more so than my Unisom or Ambien! My suggestion is to try it in the evening, if possible so you can just sleep if you get that reaction.

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ChristieNRN · November 2011

As a nurse and a soon to be mom, when my morning sickness was just more than I could take, I took zofran. Phenergan just makes people too sleepy.

I had no problems with the zofran when I took it. As far as the constipation...that happened to me because of the baby. Colace if safe to take and eating prunes or a high fiber diet....I recommend broccoli. It works.

It really does help!!! It was my miracle medication during the first trimester.

hnbarth · November 2011

I don't remember how often you take each. When we prescribe zofran to our patients I think it is every few hours. I would say Zofran during the day and Phenegran at night. From what I know Zofran works great just make sure you don't get too constipated, lots of fiber

Hope this helps

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