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Anyone with homozygous MTHFR C677T?

6-7-86-7-8 member
in Pregnant after IF

I just found out that I am homozygous MTHFR C677T.  I am trying to get my lining up for a FET. Can this disorder effect the lining? Also, did you have to be in the Folgard and baby aspirin for a certain time before trying again?  I would love to hear any success stories as well.

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Re: Anyone with homozygous MTHFR C677T?

  • may2806may2806 member

    I have it as well but as far as I know it didn't affect my lining at all - never heard those two things mentioned together. I was on Folgard and BA - I guess ideally the extra folic acid should be in your system ahead of time, but ask your doctor how much that will matter in planning your FET. Now that I'm pg I'm on Lovenox, although I've had issues with unexplained bleeding so I have no idea if it has to do with the Lovenox; so far baby is doing ok.

    Good luck! 

     

    Dx: High FSH, stage IV endo, homozygous C677T MTHFR and PAI-1
    Early loss 10/08
    Lap 1/09
    IVF #1 "natural IVF" - 1 egg retrieved, missed m/c
    Tried several mini-stim cycles with no response
    Switched clinics - dx'd as carrier for Fragile X
    IVF #2 MDL protocol Jan/Feb converted to IUI, BFN
    IVF #2 take 2: Antagonist, one embie, BFN
    IVF #3: Antagonist, no fertilization
    One last ditch effort at OE IVF (antagonist with Clomid) cancelled
    DE cycle #1 Jan/Feb 2011, BFP, ectopic
    DE cycle #2 June/July 2011 - BFP
    10/28/11 Baby girl lost at 17 weeks due to pre-term labor. We love and miss you.
    DE cycle #3 June/July 2012 - BFP, twins, both heartbeats stopped, D&C
    2 frosties but don't know what's next
    FET Dec 2012: BFP! Praying this one sticks for the long haul!
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  • mikeandangiemikeandangie

    I have it. I was on Lovenox (40cc), aspirin and extra folic acid, both while cycling and now. My MFM didn't think Lovenox was necessary, but I chose to continue it.

    As far as I know, it should not affect your lining at all. My lining was "beautiful" per RE.

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  • babylove0511babylove0511 member

    I have it. My lining was always perfect for all my transfer even before starting all the meds so I don't think it should affect it. I was on Lovenox (40cc), BA and folgard. 

    I stopped taking BA at 16 wks, still taking folgard and just switched from lovenox to heparin. 

    Good luck! 

    ::PAIF/SAIF Welcome::

    TTC since July 2008
    IUI 1,2,3 BFN
    IVF #1 C/P, FET 1,2,3 BFN
    IVF#2 BFP

    it's a girl!!

    Lilypie First Birthday tickers
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