AMH over 3, not good?

amandaleigh1 · September 2011

I was looking at the informed consent forms for an IVF drug study that I am possibly going to try to get in on, and the I was stuck by one of the requirements for qualification: "AMH level greater than 1 ng/mL and less than 3 ng/mL at screening."

Back in January, I got my AMH tested at 3.1 ng/mL which is slightly over the threshold. At the time, I was told that this was fine/good, especially for my age. Now, I sort of wonder why they don't want people in the study with higher AMH levels.

Any thoughts ladies?

happywifemomofone · September 2011

I think that AMH >3 is good. Study probably wants to control the group of subjects in their studies. If they take too many people with really good AMH, >3, then they risk the results not being considered applicable to the average woman (likely AMH between 1 and 3). Good luck-Hope that you find some good trials out there.

Mrs.McIrish · September 2011

happywifemomofone:
I think that AMH >3 is good. Study probably wants to control the group of subjects in their studies. If they take too many people with really good AMH, >3, then they risk the results not being considered applicable to the average woman (likely AMH between 1 and 3). Good luck-Hope that you find some good trials out there.

I agree with this. The study doesn't want "easy to treat" and "hard to treat" in it.

solarflare · September 2011

I hope they still let you participate in the study! Did you just e-mail or call them and they sent you information?

amandaleigh1 · September 2011

I am still trying to find out if my very borderline-too-high-for-them AMH would work, or maybe if we could try again to get a different number, since as time passes, I am assuming it will want to naturally go down! I am waiting to hear back. Unfortunately my phone call and email were not returned yesterday.

In any case, all other criteria for inclusion in the trial point only wanting to include the very easy to treat patient, only those with unexplained really qualify-- I was actually thinking maybe with the AMH criteria they were trying to avoid PCOS people who may be at higher risk for OHSS. Just a thought.

tst1998 · September 2011

An AMH over 3 can be indicative of PCOS, so it may be their way of excluding PCOS patients from the study.

tst1998 · September 2011

amandaleigh1:
I am still trying to find out if my very borderline-too-high-for-them AMH would work, or maybe if we could try again to get a different number, since as time passes, I am assuming it will want to naturally go down! I am waiting to hear back. Unfortunately my phone call and email were not returned yesterday.
In any case, all other criteria for inclusion in the trial point only wanting to include the very easy to treat patient, only those with unexplained really qualify-- I was actually thinking maybe with the AMH criteria they were trying to avoid PCOS people who may be at higher risk for OHSS. Just a thought.

Maybe I should all the responses before jumping in with my two cents? Wink

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