Tests required to detemine egg quality

SparklyCutie · September 2011

Just found out I had another c/p, I am at a loss. We know we can get pregnant, I just cannot carry for some reason. Starting to wonder if it's my eggs. We have had all RPL tests done and everything came back normal .What are we missing??

howleyshell · September 2011

This sucks.

Bad.

I'm sooo incredibly sorry.

Have you had an AMH run?

Cassian · September 2011

How is your luteal phase?

I am so so sorry you have to keep going through this. I hope you can get some answers

SparklyCutie · September 2011

What is an AMH? We may call things differently here in Canada...but I am grasping at straws at this point.

Carrie25 · September 2011

I don't know if a RPL includes clotting issues...but maybe that?

futureMrs.Eanes · September 2011

I just want to say that I am so, so sorry. I really hope you get some answers soon.

howleyshell · September 2011

SparklyCutie:
What is an AMH? We may call things differently here in Canada...but I am grasping at straws at this point.

https://www.advancedfertility.com/amh-fertility-test.htm

anti-mullerian hormone:

What is AMH?AMH, or anti-mullerian hormone is a substance that is produced by granulosa cells in ovarian follicles.It is first made in primary follicles that advance from the primordial follicle stage. At these stages follicles are microscopic and can not be seen by ultrasound.AMH production is highest in preantral and small antral stages (less than 4mm diameter) of follicle development.Production decreases and then stops as follicles grow. There is almost no AMH made in follicles over 8mm.Therefore, the levels are constant and the AMH test can be done on any day of a woman's cycle.Related PagesOvarian Reserve ProblemsAntral Follicle CountsDay 3 FSH TestAge and FertilityIVF Ovarian StimulationIVF costsIn vitro fertilization - IVFInsemination - IUIIVF Success RatesEgg Donation Donor Egg Success RatesAMH and fertility

How can AMH hormone levels be a fertility test?
Since AMH is produced only in small ovarian follicles, blood levels of this substance have been used to attempt to measure the size of the pool of growing follicles in women.Research shows that the size of the pool of growing follicles is heavily influenced by the size of the pool of remaining primordial follicles (microscopic follicles in "deep sleep").Therefore, AMH blood levels are thought to reflect the size of the remaining egg supply - or "ovarian reserve".With increasing female age, the size of their pool of remaining microscopic follicles decreases. Likewise, their blood AMH levels and the number of ovarian antral follicles visible on ultrasound also decreases.Women with many small follicles, such as those with polycystic ovaries have high AMH hormone values and women that have few remaining follicles and those that are close to menopause have low anti-mullerian hormone levels.AMH levels and pregnancy chances with in vitro fertilizationWomen with higher AMH values will tend to have better response to ovarian stimulation for IVF and have more eggs retrieved. In general, having more eggs with IVF gives a higher success rate.We do not have a lot of data yet on what to tell couples going through IVF about their AMH results and chances for conception. However, the table below shows ranges for AMH levels and some information about interpretation.AMH levels probably do not reflect egg quality, but having more eggs at the IVF egg retrieval gives us more to work with - so we are more likely to have at least one high quality embryo available for transfer back to the uterus.What is a normal AMH level?Interpretation of anti-mullerian hormone levels and chances for conceptionThere are some problems involved with interpretation of AMH hormone levels. Because the test has not been in routine use for many years, the levels considered to be "normal" are not yet clarified and agreed on by the experts. Also, not all current commercial assays give equivalent results.The table below has AMH interpretation guidelines from the fertility literature and our own experience. Do not get carried away with the cutoff values shown here. For example, the difference between a 0.6 and a 0.7 ng/ml test result puts a woman in a "different box" in this table - but there is very little real difference in fertility potential. In reality, it is a continuum - and not something that categorizes well.InterpretationAMH Blood LevelHigh (often PCOS)Over 3.0 ng/mlNormalOver 1.0 ng/mlLow Normal Range0.7 - 0.9 ng/mlLow0.3 - 0.6 ng/mlVery LowLess than 0.3 ng/mlMore will be learned regarding anti-mullerian hormone levels and outcomes as we continue to use the AMH fertility test and study the relationship between AMH hormone values and fertility, ovarian responsiveness, chances for IVF success, etc.Ovarian reserve testing methodsAnti mullerian hormone is one potential test of ovarian reserve. There are other tests that are currently used for evaluation of the remaining egg supply. None of the tests are perfect, and fertility specialists will often use a combination of tests to try to get a better estimate of the size of the remaining egg supply.Note: Anti mullerian hormone has also been referred to (mostly in the past) as "mullerian inhibiting substance", or MIS.

SparklyCutie · September 2011

Cassian:

How is your luteal phase?

I am so so sorry you have to keep going through this. I hope you can get some answers

luteal phase is fine. My p4 was 29, so i don't think there is an issue with progesterone

etoyama · September 2011

I'm so sorry

I hope you are able to get some answers.

Happycouple · September 2011

I am very sorry to hear this news

I am not sure what is involved in RPL testing, but Im assuming you have had your FSH tested......?

WillisReincarnated · September 2011

I'm so sorry for your losses. Unfortunately the only thing that can determine egg quality is ivf. Amh can indicate your reserve, but my re feels strongly that it doesn't indicate quality.

Want a personalized experience?

Tests required to detemine egg quality

Re: Tests required to detemine egg quality

Choose Another Board

Search Boards