PIO vs Crinone (I know it's been asked)

naflmj · August 2011

Is it worth asking for PIO? I have never been on it before and had a successfull first IVF w/crinone but I hate that it can cause spotting and I don't want to deal with that this time around. I asked RE about it and basically he said there was no reason to switch and that they were equally effective. I brought up being able to monitor progesterone and he said that measuring doesn't necessarily mean that it's getting where it's supposed to go so even if I push it, I doubt my progesterone will be monitored. Is it worth pushing for? FWIW, though I think the sups are nasty, that's not what makes me want PIO.

Kmarie823 · August 2011

I think every RE has their own methodology on this. My offered for me to switch to supps at 8 weeks if I wanted to but preferred for me to stay on PIO.

Personally I wouldn't want to deal with the mess of doing supps and I even had an awful reaction to the PIO around 8 weeks where I could barely walk due to soreness. I chose to stay on the PIO because it was doing its job.

I did have an early triplet loss though so I'm not sure if that played into my RE's opinion for me to stay on PIO. All in all I think it should be the patients choice. If he says it is "equally effective" then why should it matter if you want to switch?

Also, for me the PIO was less expensive than the supps. I was glad to save a little $$ since I took it for 13 weeks!

Man that was long winded... sorry!

kthappy76 · August 2011

PIO is literally a huge PITA. If you've had success w/supps, I don't see a reason to change. I was on supps for my fresh cycle and had an unexplained m/c, so they gave me no choice but to use PIO for my FET. It sucks worse than supps, trust me. GL!

gymnst1013 · August 2011

Personally, I don't feel there is a need to ask for it. My RE initially prescribed me PIO but when I told them MH was going to be out of town right after ER, they switched to crinone (they were convinced I couldn't give myself the injections). They said there is absolutely no difference in effectiveness. They didn't monitor my progesterone.

krissyh21 · August 2011

My clinic didn't care really. There normal protocol was supps. (whichever one I could get my insurance to cover Crinone or Prometrium) so my financial person at the clinic called insurance to find neither were covered but PIO could be. I actually opted for the supps. in the end because the thought of shooting myself in the butt where there were still welts from my last cycle was not too appealing for me and I dreaded that more then paying for the supps. (shhh don't tell H)! So my answer would be not to push it. Lol

naflmj · August 2011

kthappy76:
PIO is literally a huge PITA. If you've had success w/supps, I don't see a reason to change. I was on supps for my fresh cycle and had an unexplained m/c, so they gave me no choice but to use PIO for my FET. It sucks worse than supps, trust me. GL!

I did have an unexplained m/c with number 2...obviously I can pin it on sups since #1 was picture perfect but I just am nervous.

gringa78 · August 2011

I've been on both, and my current RE actually had me alternate them during my FET cycle. Now that I'm pregnant, his orders are to do just Crinone up to 10 weeks. I felt a little uneasy giving up the shots, but everything seems to be going ok.

kthappy76 · August 2011

naflmj:

kthappy76:
PIO is literally a huge PITA. If you've had success w/supps, I don't see a reason to change. I was on supps for my fresh cycle and had an unexplained m/c, so they gave me no choice but to use PIO for my FET. It sucks worse than supps, trust me. GL!

I did have an unexplained m/c with number 2...obviously I can pin it on sups since #1 was picture perfect but I just am nervous.

I've never heard of an RE refusing to let someone switch from supps to PIO (vs the other way), so if it would make you feel better definitely ask/request this. PIO is usually cheaper, but the pain is so not worth the savings, though success is obviously priceless. My butt still hurts.

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PIO vs Crinone (I know it's been asked)

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