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not sure if i'm in the right place but i have questions (ivf with PGD, recurrent losses)

mrs.viv07mrs.viv07 member
in Success after IF

it was suggested to come here because you ladie may have a bit more insight to some of my questions.
i guess i should start with a brief background

i had my fisrt son at 21 and it was perfect pregnancy, towards the end i was rear-ended at about 32 weeks and was in the hospital for 4 days and they were able to stop ctx then i was monitored and around 39 weeks i was induceed due to low fluid. he was born perfect and still is.

we started trying again when he was 5 and after 2 years, leep procedure, HSG i conceived in dec 20th 2007, e lost that baby on feb 2008, then an ectopic then, 2 missed m/c all in 2008 and finally a CP in early 2009. after all this we had genetic testing done once and it came back trisomy 16, i was also dx with hetero compound MTHFR and we decided i had to be on baby aspirin and folic acid for the rest of my life. also progesterone pills from 3DPO till AF or BFP in which case lovenox once a day would be started. i conceived my LO may 2009 and  in jan 2010 he was born at 39 weeks.
we started TTC again jan 2011 and mother's day i got my BFP. last week was our first u/s and the baby measured about a week behind BUT we saw a HB of 100 so the dr. wasn't worried. today was a repeat u/s and there was no growth and no matter how hard she triedn , she couldn't find a HB. we have a D&C scheduled for this friday and a meeting with an RE on monday.

it was also mentioned in the whirlwind that was this morning that /////ivf with pgd may be an option since even though way to early to be sure, my eggs may be the culprit, and i kind of of hope so because i find it so hard to believe one person can have so much bad luck and beat so many statistics9 i could be wrong though)

i guess i'm just searching for some advice and maybe if anyone on here has done pgd if that is a good option for us, because to be honest i'm don't know what else to search for on google and don't really know where we stand other than being heartbroken yet again.

thanks in advance for any help you guys can offer

BFP #1 May 2000 ~ Darren was born Jan 13, 2001 ~ 6lbs 2oz 191/2" ~ 39 wks due to low fluid, otherwise perfect pregnancy
July 2004 abnormal pap, colposcopy and LEEP procedure ~ paps every 3 months all normal for 1 year
2006 all clear to start TTC
HSG Nov 2007 ~ all normal except mild left tube blockage
BFP #2 Dec 2007 EDD sept 3 ~ missed m/c ~ Feb 14 2008 ~ 9wk 2d D&C
BFP #3 Apr 2008 EDD Dec 10 ~ ectopic ~ May 2008 ~ 5wk 2d ~ emergency lap surgery, lost left tube
BFP #4 Jul 2008 EDD May 5 ~ missed m/c ~ Aug 2008 ~ 5wk 2d D&C - trisomy 16
RPL panel Aug 2008 ~ diagnosed with compound hetero MTHFR
BFP #5 Nov 2008 EDD Jul 31 ~ blighted Ovum ~ Dec 2008 ~ 4wk 3d ~ natural m/c at home for my birthday
BFP #6 Feb 2009 EDD Oct 15 ~ 4wk 3d ~ chemical pregnancy ~ Mar 2008
BFP #7 May 18 2009 ~ Gabriel Michael ~ Jan 19, 2010 ~ 7lbs 2oz 21"
TTC again since Jan 2011
BFP #8 Jun 2011 EDD Jan 20 ~ 5wk 6d ~ missed m/c ~ D&C
July - Hysterscopy removed some polyps, all clear for IUI with clomid
Aug-Oct - IUI - with Clomid all BFN
Nov-Jan - IUI - with femara and trigger = BFN
back to TTC naturally on our own hoping for another miracle.
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Re: not sure if i'm in the right place but i have questions (ivf with PGD, recurrent losses)

  • gringa78gringa78

    I'm so sorry for all of your losses.

    I think you should go see an RE.  Your losses could be due to a number of things besides genetic disorders.  Set up a consultation appointment and discuss your history with him or her...a physician will know the best path to take.

    Good luck!

    PCOS, lupus anticoagulant, MTHFR (A1298C, one copy) 2 IUIs & 1 IVF = BFN FET#1 = It's a girl! Born 7.1.10 FET#2 = c/p FET#3 = Twin girls! Born on 3.16.12 at 33w2d due to severe pre-E. After 4 weeks in the NICU they are home! Lilypie Third Birthday tickers
    Lilypie Premature Baby tickers
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  • yodasmistressyodasmistress member

    We did a type of PGD called Comprehensive Chromosome Screening (CCS) where they check to make sure all 46 chromosmes are there and in tact.  For people who have a higher potential for translocations that would not show up during CCS, Flurescent In Situ Hybirdization (FISH) analysis can also be done.  I'm sure it sounds like I"m speaking greek.  Quite frankly, it's because I am.  IVF with PGD is serious stuff and not something you're going to get good feedback on here.  I agree with prior poster that you should see a Reproductive Endocrinologist (RE).  Any RE that does PGD will have a Genetic Counselor on staff - that is who you really need to talk to. 

     
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  • +jenjen++jenjen+

    I'm so sorry for your losses :(  I've had 2 m/c and know how much it sucks. 

    We did IVF with PGD because DH and I are both carriers of Cystic Fibrosis, but I don't think that it sounds like it's right for you.  PGD is used to detect a single known genetic mutation...for example, they knew the precise location on the specific chromosome for us to look for the CF.  But I don't think you know exactly what your issue might be, right?

    For recurrent losses, I think you would be a candidate for CGH or CCS (as Yoda mentioned above) where they actually test each chromosome for abnormalities.  It has to be done in conjunction with IVF so they biopsy a cell from each embryo on day 3, then grow them and test each chromosome and transfer back the genetically normal embryos.  I think they biopsy the cells, then freeze all the embryos because the testing takes a month or so, then you would actually do a Frozen Embryo Transfer of the healthy embryos.

    I hope all that made sense....

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