MTHFR?

huffinlove · March 2011

Hello! I just recently got the call that one of the blood tests they ran on me after my m/c came back positive. It is the MTHFR one. I won't be able to talk to my nurse until tomorrow, so I am just looking for others that know more about this. THANKS! Off to google.......:)

jen629 · March 2011

Do you know if it was Hetero or Homo? Did they check your homocysteine level?

huffinlove · March 2011

Homo.....

She also said something about doing a fasting homocysteine test?!

Carolee · March 2011

There is a link in the TTCAL blog about MTHFR. https://ttcalblog.blogspot.com/ Go to the resource tab and scroll down, you'll see it. I have it.

gracie5107 · March 2011

I'm heterozygous for MTHFR. It's a really common chromosomal mutation (I think 40% of people have some type of the mutation) and doctor's vary greatly on how they think it plays a role (or not) in MC. I had to have my homocysteine level tested and it came back normal. Therefore, my doctor only wants me to take extra folic acid and that's it. Some doctor's prescribe nothing unless the homocysteine is elevated, some prescribe folic acid and baby asprin, and some prescribe folic acid and heparin or lovenox injections (blood thinners) once you become pregnant again. I second the blog post from above. I think I got the best information from that. Internet searches gave me such conflicing information that it made me crazy.

Elle Mae · March 2011

My and I are both homozygous for MTHFR C677T, so all of our children also have 2 C677T. The reduced MTHFR function causes the inability of the body to convert homocysteine to the methionine synthase pathway for the end result of our bodies manufacturing glutathione. Since we have 2 snips our bodies can not process the metals, and you add mercury and aluminum via vaccinations ( both neuro toxins your resut is heavy metal poisoning that has the same symptoms as autism. Of course this goes hand in hand with the addition of the Hep B shot and HIB shot added to the pediatric vaccine schedule in 1991 increasing the amount of thimerosal exposure in the first 18 months of life by 300%. Myself and 3 children have all been diagnosed with Mercury poisoning via an urinary porphyrin profile My youngest son who is vaccine injured the most (Autism) his mercury was the highest by 3 fold. If we would test for MTHFR at birth, like we test for PKU, than we could identify those who can not process metals.

Here is the protocol from a OBGYN in Richland WA . It took him 4 years and the Humane Genome Project to help his son by finding out they all tested positive for the MTHFR Gene A12098/T677C. Hopefully this will help you better understand what you should do with this gene.

MTHFR

MethylTetraHydroFolate Reductase Deficiency

New approach to medical problems from the Human Genome project

Goal of the project was to identify genetic disorders that cause disease and then treat the cause not just the symptoms. MTHFR is the first one to have an FDA approved treatment. There are two common variants that can be tested (677, 1298) but as many as 50+ variants. If both genes are defective the pathway functions on about 10-15% at best.

FDA approved treatments are for

Anxiety, Depression Deplin

Memory Loss Cerefolin

Diabetic neuropathy (nerve Pain) Meta NX

High Risk Pregnancy Neevo, Neevo DHA, Prenate Elite, Thorne

Other symptoms that are treated by this pathway but don have FDA approval

Elevated Homocysteine, fibromyalgia, chronic fatigue, Irritable Bowel, Migraines, Alzheimers, Chronic pain, Bipolar, Schizophrenia, Parkinson?s, as well as prevention of Congenital anomalies, Down?s Syndrome. Without treatment people are more prone to viral infections because the Methylation process is critical in shutting off viral replication as well as retaining heavy metals and other environmental toxins.

Who Benefits?

30 % of the population have both genes defective

40% have one gene defective

100% are exposed to environmental toxins that affect this pathway (BPA)

Effects of low Methylfolate

Low Seritonin, Dopamine, Norepinepherine

Low Glutathione. Needed for toxin removal and Memory

Low Tetrahydrobiopterine. Critical in nerve protection, neurotransmitters

Things that aggravate the genetic disorder

Heavy Metal load (fish, water, food) (mercury, lead, aluminum)
Poor diet (highly processed foods)
Medications (Glucophage, Birth Control, Levodopa)
Anesthesia (Nitrous Oxide)
Other enzyme defects (B6 conversion, Methionine synthase and reductase)
Other diseases (diabetes, Lymphoma)
Leiden Factor V, Prothrombin 20210

MEASURES THAT IMPROVE SYMPTOMS:

Dietary, vegetables, berries, fruits (better if fresh) Berries have the active form of folic acid already
Mathematics, Accounting ? Engineers, creative people because it regulates the Anterior cingulate cortex
Piano, Classical music -- Supresses the serotonin related areas
Exercise

Band (not rock band) participation (structured music)

Nutritional protocol for MTHFR

Revised 7/21/2010

The Human Genome project has developed a new approach to medical problems. There are several of the B vitamins that require activation before they are useful to the body. By taking the active forms of theses vitamins you are able to bypass metabolic glitches and compensate for genetic and environmental problems. The MTHFR genetic defect is in between 40-60 % of the population. It is associated with problems such as early heart disease, stroke, Blood Clots, Depression, Anxiety, Irritable Bowel syndrome, Fibromyalgia, Chronic Fatigue, Chronic pain, Migraines as well as heavy metal and other environment toxin retention. This protocol is designed to help treat these problems with nutritional therapy. It is not designed to replace your medications however you may be able to over time decrease the medications that you require to manage these problems. The Supplements should be added one at a time rather than start them all at once.

METHYL FOLATE (Prescription)

Deplin 7.5, 15 mg a day. This is just the Methylfolate and tends to increase energy. Take 7.5 mg at a time. If taking 15 mg take ? in the am and ? at noon. Most widely used.

MetaNX 1-2 tablets/day Methylfolate (B9), Vit B6 (Pyridoxyl 5 Phosphate), Methyl B 12 Methylcobalamin. This works well 6 months to 1 year. In a small percent of the population the Vit B6 builds up and creates a tight band type headache. Great for surgical wound healing

CerefolinNAC. One tablet a day. This is for Methylfolate, Methyl B12 and N-acetyl cysteine that helps form Glutathione. Glutathione is important in memory and clearing Heavy Metals.

Neevo Prenatal, Prenate Elite, Thorne Prenatal These prenatals contain Methylfolate

OVER THE COUNTER OPTIONS

Methylfolate (MTHF). 1mg. also available at Malley?s Pharmacy or Prescription pharmacy age 8-12, 1 tab, age 12+, 2 tabs (7.5 tablets are equivalent to 1 Deplin)

Methyl-Guard. Thorne Pharmacuticals Available at Malley?s Pharmacy, Prescription pharmacy age 0-3, 1 capsule, age 3-5. 2 capsules, age 6-8. 3 capsules. (6 tablets are approx equal to MetaNX)

You may require additional supplementation to support this pathway.

Options for Methyl B12 :

Methyl B-12 5000mcg. Oral dissolving tablets every day (usually 1 but up to 4x/day)

Methyl B12 oral drops Richland Clinic Pharmacy or Biogenesis (called Methyl Protect) on line. This works well for infants and children.

Methyl B-12 (15 or 25mg/ml) 0.1-0.5ml sub-cutaneous injection every 1-3 days

It can lower blood sugars at about 8 hours. In diabetes it seems to work bests daily.

Your urine may be an orange-red about 4-6 hours after the shot. That is your body clearing the excess. I have found that some people that are very ill have not noticed this till several weeks into treatment. The injection has to be compounded, needs a prescription and be refrigerated. Regular compounding pharmacies do not have the special equipment to do this. Some pharmacies that do:

Malley?s Pharmacy 509-943-3030 (local)

Hopewell Pharmacy NJ 800-792-6670.

Moses Lake WA Pharmacy 800-476-6505

Other supplements that seem to help with this particular metabolic pathway include::

N Acetyl Cysteine 600 mg Once a day

This helps make glutathione which clears heavy metals, Seems to help with memory

Full Spectrum Minerals Mineral supplement with Amino Acid Chelate (AAC)

Take one a day. NOW brand and others are available.

Vit B6 (Pyridoxyl 5 Phosphate or P5P), 25 mg This is in Meta NX. Can be added to Deplin

This B vitamin can build up in some people and it causes a headache that feels like a tight band.

Vitamin C 1,000-3000 mg up to 3 times a day

This helps with regenerating glutathione as well as helping to have 2-5 BM/ day

Epsom Salt bath Soak feet or body with ? -1 cup of salts 2/3 times/week

? The magnesium absorbs directly. It helps with improving the mineral balance. It also adds the sulfate that is critical in clearing toxins. It is not well absorbed orally.

DMG-Dimethylglycine. (another option in TMG) 100-250mg/day Start with one a day

This adds methyl groups to the amino acid that your body uses in the methylation.

Zinc 20 -50 mg/ day Especially important in eye sensitivity which is common.

Omega 3 (Flax seed or Fish oil that has mercury removed) 1-2 tablets per day

Some of the fish oil tablets don?t have the mercury removed. Helpful with brain/nerve healing

Vitamin E 400 IU Once a day

Silymarin (milk weed Thistle) 150 mg 1-2 tabs/day. Boosts glutathione

Glutathione SR (Thorne pharmaceuticals). 1-2 tablets/d This may give symptoms as the toxins come out so it may be useful to do on a 3 days on, 4-11 days off. Available at Malley?s Pharmacy

5-9 serving?s of fruits and vegetables are key to getting many of the minor but essential nutrients.

Laboratory evaluation may be useful. This allows testing for the genetic predisposition and looks for toxicity in the B6. It helps identify people who would benefit from long term therapy.

MTHFR (methytetrahydrofolate Reductase) This is an initial test for gene defect.

Homocysteine This seems to be optimal if under 6.3. Do baseline and follow if over 7.5.

HbA1C. This is a estimate of glucose intolerance. If in the 5.5 to 8 range you can have more problems with dosing the Methyl B12 and it should be given every day.

MTHFR tests only two of the common genetic variants. There are as many as 50+ variants to this gene alone. You get one from each parent. Possible combinations of these two are:

Normal/Normal It doesn?t test for the environmental toxicity or the minor defects.

Normal/ 677 More susceptible to environmental damage, depression, addiction

Normal/ 1298 More susceptible to environmental damage, depression, addiction

677/677 This means exposure to Lead, Mercury, and Pesticides may not clear well

1298/1298 This means exposure to Lead, Mercury, and Pesticides may not clear well

677/1298 As noted above this genetic defect has increases in strokes/heart disease/ blood clots. Nutritionally bypassing these defective Genes with the above protocol is very important. It may also be important to take an aspirin daily. All of the defective MTHFR genes are associated with Depression, Irritable Bowel, Fibromyalgia, Migraines and Chronic Fatigue and may make you more susceptible to viral infections especially Mononucleosis. Avoiding environmental toxins like BPA (plastic stuff), Mercury, Lead and by drinking filtered water in a stainless steel or BPA free plastic helps treat with getting better and avoiding future problems.

Changing the course of Autism, The scientific approach for parents and physicians. Bryan Jepson, MD. This book talks about the importance of these supplements.

Magnificent Mind at any Age, by Daniel Amen. An excellent resource on treating the effects of this gene

An old version of my MTHFR presentation was put on a web site by my niece. https://www.renewashoe.com/medical/

Also, google NW Integrative Medicine. Dr. Stephen Smith has put Dr. Neil Rawlins lectures on his web site along with his grids explaining how to treat MTHFR and diseases MTHFR causes. This grid is very limited on the diseases and mental illness MTHFR causes. You can google just about any disease/mental illness etc... and you will see that this gene and its variations cause so many issues.

Learn about this so you will not go through the hell I have gone through with my family. The longer you do not treat this and get the toxins methylating out of your body you will experience many horrible illnesses the older you become. This is so simple to treat. So many kids with ADD, Autism, Spina Bifida, Down Syndrome, Sturge Weber, Hearing Loss, Speech, Auditory Processing, Language Delays etc.. who not be here if we just tested our women before they get pregnant, DO NOT VACCINATE OUR CHILDREN OR PEOPLE IN GENERAL.

Learn about mercury on www.mercurypoisoned.com

Get all silver amalgam fillings out of your mouth!

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