translocation? (pics/tics)

xnbride · February 2011

Who has experience and/or knowledge with this? Please provide any information that you can including sites, resources, links etc.

My midwife thinks that this is probably the cause of our losses and I want to do as much research as possible on it. Thank you for your help.

sdlaura · February 2011

Have you checked out the boards on babycenter? I know that some of the women on the "Termination for Medical Reasons" board have dealt with translocations...good luck!

mrs.gee · February 2011

I'm sorry for your losses. My second m/c was due to an unbalanced translocation. My husband and I had our chromosomes tested and ours were fine, so it seems the issue was just bad luck. Even though it's simplistic, I found this blog post useful to understand what might have been going on: https://julia.typepad.com/julia/2005/05/balanced_transl.html.

Can I ask why your midwife thinks this is the case? Did you have your miscarriages tested?

GPickles · February 2011

My niece has 1 p 36 deletion and 7 q duplication syndrome. One part of the 7th chromosome duplicated and translocated to the first chromosome where part of it was missing. I know quite a bit about her chromosome abnormalities, but not much about other kinds of translocation. This is quite rare and she is the only documented case ever of having both abnomalities together. My sister sees a genetic counselor at the Cleveland Clinic and this was just a chance event and can't be traced back to anything that she might pass on.

romigu · February 2011

So generally speaking, each chromosome has specific "code" on it that leads to development of that particular part of the body that its meant to program. A translocation is a part of the "code" in the chromosome that was supposed to be on one chromosome that is switched with another portion of a different chromosome. Because that translocated portion ends up on the wrong chromosome, the chromosome no longer works the way its supposed to. I'm not sure what the relationship is with miscarriage nor do I understand how your midwife would know that without having a sample of the fetus to analyze. I hope this helps.

brenn · February 2011

I'm sorry for your losses. After my two recent losses DH and I were tested (based off translocation found in d&c chromosome analysis). Results came in just a few weeks ago and turns out I have a balanced translocation. I've done a ton of research and we met with a genetic counselor (not helpful at all). I believe a PP mentioned Shemico on the PGAL board. I exchanged a few messages with her and it helped to hear her story. Are you and your DH or SO doing bloodwork to get tested? Feel free to send me a PM if you have any questions.

xnbride · February 2011

Thanks ladies. My midwife said this based on my medical history and nature of my losses and experiences with my pregnancies with my boys that she thought it was probably very likely. I do trust her insight as she has been doing it for quite some time but obviously we don't have a definitive answer since the testing is so expensive and will not really change the outcome.

I will page you Brenn in a few moments and also will see if I can get ahold of shemico as well.

Shemico · February 2011

TICKER WARNING.

I felt my ears burning

Story in siggy and link to bio, but in a nut shell: 1 healthy DD (may or may not have balanced translocation), followed by 4 losses (my translocation discovered after the 3rd) and now almost 36 weeks with DD#2 (who has the same balanced translocation as me).

If this is the issue, what it comes down to is each pregnancy you have a 50/50 shot of having it succeed (either normal or with the same balanced transclocation).

Unfortunalty those odds don't change with each pregnancy. There are some people that will have no losses and some that will have dozens.

Its usually advisable to have CVS or Amnio done in pregnacy as well, as some peoples translocations can lead to unbalanced transclocations where it may cause a later loss, still birth or very severe disability. I opted for an amnio in this pregnancy.

Please feel free to PM me with any questions.

- S

xnbride · February 2011

Shemico:
TICKER WARNING.

I felt my ears burning

Story in siggy and link to bio, but in a nut shell: 1 healthy DD (may or may not have balanced translocation), followed by 4 losses (my translocation discovered after the 3rd) and now almost 36 weeks with DD#2 (who has the same balanced translocation as me).

If this is the issue, what it comes down to is each pregnancy you have a 50/50 shot of having it succeed (either normal or with the same balanced transclocation).

Unfortunalty those odds don't change with each pregnancy. There are some people that will have no losses and some that will have dozens.

Its usually advisable to have CVS or Amnio done in pregnacy as well, as some peoples translocations can lead to unbalanced transclocations where it may cause a later loss, still birth or very severe disability. I opted for an amnio in this pregnancy.

Please feel free to PM me with any questions.

- S

shemico you have a PM-thank you!

Want a personalized experience?

translocation? (pics/tics)

Re: translocation? (pics/tics)

Choose Another Board

Search Boards