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Scout05 · January 2011

I answered your DX post below, but I wondered what, if any, other testing your doctor had persued for you beyond the standard RPL panel?

If you haven't already, I would look into a full karyotype on you and DH (it is possible, with your history, to have had successful pregnancies and still have a translocation going on), AMH levels, CD 3 base line hormone level check, etc.

If they only did the standard RPL panel, they are missing a lot of other possibilities. It wasn't until we had run ALL the tests that we seem to have found the answer to our issues - the homzygous MTHFR was not the whole story, and we only discovered that when they checked CD 3 base line levels.

For us, it was a combo of treating the MTHFR issues (folate blockage and clotting threat) and the elevated estrogen that was causing me to ovulate early, immature eggs. So it was FA, BA, Lovenox injections for the one (and total cut off from caffeine, which was BRUTAL), and then Gonal-F to supress O, Ovidrel to trigger, and then timed intercourse. I truly believe it had to be this combination that got us to where we are - the evidence is too strong for me to believe otherwise.

Good luck, and I would ask about these other tests if they have not already been ordered for you. I hope your RE or OB is as proactive as possible - I know there are not always answers, but to me, with your history, I feel like there's something they aren't finding and I want you to get that information if it is at all possible to do so.

xnbride · January 2011

Thank you for the input. I have been thinking that perhaps it is a translocation issue. There would be a alot of evidence to suggest that is what it is considering my history.

About how much would that run? Honestly I doubt we would want to pursue intensive testing if it is not really going to change anything (does that make sense).

From what I know about translocation it is really just the luck of the draw right? That there is nothing I can really do to change the outcome unless we were to pay for PGD (or something along those lines)?

Basically we just have to keep trying and trying until one sticks.

What specifically should I ask for regarding testing? I have an appt next Friday with my midwife.

Thanks for your input!

Scout05 · January 2011

Our testing ran about $3,000 for the karyotypes (insurance did not cover it). But some companies do, so it would be worth looking into that.

Yes, once you discover a translocation, really your only option to work around it is IVF w/ PGD. For us, given that we did not have any living children, it was route we were willing to go, but I know it's not an option everyone is open to.

There's also just the closure of knowing what's going on, you know?

I would go in and ask your MW if she (he) thinks talking to an RE about further testing is a good idea. The RE should have a list of tests they want to run; you can research them and decide which ones you want to go with.

FWIW, I was CONVINCED we were dealing with a translocation or other chromosomal issue, and it ended up being purely hormonal. And that is something they can work with - for us, it involved delaying O for a few days. That was the big "ta da!" difference, which seems so simple and silly now.

If I could, I would reverse the order of our testing and do the CD 3 base line test first (much cheaper) and then have moved to the karyotype had nothing popped there.

For me, I was not willing to accept that nothing was wrong. You just don't have five miscarriages by the time you are 28, with no family history of loss, and nothing be wrong. At least, I didn't think so.

Good luck!

xnbride · January 2011

As an aside: what kind of dog is that? It looks like our dog Winston. He is a wired haired dachshund.

xnbride · January 2011

Thank you again for your input. I am curious to see what my MW will have to say at the appt.

It would be nice to have an answer but it is unfortunate that it wont' really change the outcome either way. I feel very blessed for what I do have and it makes me appreciate them all the more.

RE family history of loss, both DH and I have family histories. My grandmother actually took DES with her first two pregnancies (because she had several late losses) but she did not take it with my mom. Both of those children (my uncle and aunt) ended up having severe mental issues and reproductive health issues. On my DH's side I am aware of some losses as well. Don't know if there is a correlation or not but I have wondered about it. My mom had no problems at all though. She did say that she thought she had a chemical pregnancy right before she had my sister.

Scout05 · January 2011

xnbride:
As an aside: what kind of dog is that? It looks like our dog Winston. He is a wired haired dachshund.

She's a goldendoodle, the costume is covering up her Doodleness

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