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Trouble TTC
WWYD? ET
So as many of you know, I have been through 2 IVFs with no sucess. Each time they transferred two back. I only have one frozen embryo. They seem to think my embryos arrest. So for this IVF cycle instead of Long Lupron we are trying antagonist and I am using PIO instead of crinone. My RE wants to transfer 4 embryos this time. This scares me. DH is fine with it and the RE insists on it. I know there is a very, very, very slim chance that all 4 will take but with a different protocol maybe things will go better this time. I'm kind of on the fence so I guess I should just trust DH and my RE but WWYD? Would you transfer 4? I was thinking 3. I don't know. I have an appointment this afternoon with my RE to discuss. The decision does not have to be made today but we are going to talk it over.
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Re: WWYD? ET
I would trust the MD, but I think I would be nervous about 4 too. Talk to him about the difference between 3 and 4.
That is a tough call, since you have already been through it twice. GL with with him today.
I have to tell you I'm surprised any RE would suggest this before even seeing the quality of your embryos.
And I'd ask your RE (and also talk with your DH) about that slim possibility that all 4 stick. Would your RE then suggest SR? Such a tough decision. Hopefully you end up with beautiful embies and you don't have to worry about transferring 4.
Are you making other changes this cycle besides the protocol? Acupuncture, diet changes, etc.? Hope it's ok that I answered. Just thought I'd throw in my thoughts since I've done multiple IVFs.
That is a tough decision. I would definitely discuss that you are thinking about 3 as another option and go through all of your concerns.
Good Luck at your appointment this afternoon. I hope you are able to get some info to help you make this decision.
Let us know how it goes.
I don't know, this is a tough one:) I would think since your protocol is changing and like you said maybe your embies will be better quality, you can decide during ET time or when you get your fert report? I would probably transfer 4 if I was in your shoes, but I understand your fears. Good luck and I really hope this change in protocol brings you a BFP!
Just curious, did they say why you are changing from Crinone to PIO?
I don't mind you answering at all! I have been doing acupuncture as well. No diet changes. The ones they have been transferring have been all good quality. As my RE said everything looks perfect and then I just don't get pregnant. They are not sure if it is a gene mutation problem. I don't get a lot of eggs - Usually 7. They all fertilize and all start growing and then BFN and no frozen embryos (except that one).
ETA: I forgot to say...I have talked to DH about if all 4 do stick but he just said, Well that is not going to happen
I will talk to RE about SR. I don't like the idea of that at all. It makes me sick to my stomach.
I requested it. I know I'm crazy but every IVF cycle I have been getting AF days before my beta. My RE said that is ok but my gut keeps telling me I should just try the PIO and see if it helps.
I have been doing Prometrium 200mg=2 caps every am & hs and Crinone every am. My p4 levels 8dp5dt was 8.4 and I just wondered if my p4 was too low for proper implantation? I know they did blood work 2 days prior to my ET and I am going to find out what my levels where...now you got me wondering! I do know that Crinone can't be measured in the blood, but wonder how much more can the RE's say it adds to you number?
I read somewhere that enough p4 needs to be present to ensure a healthy environment for implantation? I also think PIO is better for some crazy reason, at least they can measure this in your blood work.
My RE is all for Crinone and does not think it makes a difference but he will let me do PIO for my piece of mind. I honestly don't understand enough about it but I got frustrated that AF kept coming when I thought Progesterone would keep it away. My RE probably thinks I'm crazy but my gut keeps telling me this is the right way to go.
4 would scare me as well. What does the RE say the difference is between putting back 3 vs 4?
Even though your H doesn't think all will stick, I think you should both be on the same page about SR beforehand, just in case.
A bit off this topic: What clinic are you going to? Just curious as if this IVF doesn't work, I'll be looking to go somewhere less @ss-tight conservative (I have to battle them to just transfer 2).
"Most of the important things in the world have been accomplished by people who have kept on trying when there seemed to be no hope at all." -- Dale Carnegie
"Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time." --Thomas A. Edison
I agree and truly believe you should follow your gut instinct and push for certain things you believe will make a difference in you cycle. I asked my RE why Crinone versus PIO and he said the same as your Re...no difference? He said since 2008 he has used Crinone and has not seen a difference in outcome. Good luck!
I would discuss it with your RE. Last cycle I transferred 3 and again had none stick. So, I would be open to the possibility of four (if I actually had four - that hasn't happened yet). But, part of it is a quality thing. If you had four really high quality, I wouldn't transfer 4. If you were looking at transferring 2/3 high quality and one that is lower quality, then that would be different. I would definitely discuss it with your RE and kind of figure things out a bit.
We were okay with 3. If all 3 stuck, there would be risks but it was unlikely especially since one of the blasts was of poor quality. I could not do selective reduction. That really limits how many we can transfer. If we were to get PG with triplets, my previous RE would have suggested SR. I just couldn't do it.
I'm sorry you are even at the point of having to make this sort of decision. I really hope you can reach an understanding with your RE with which you are comfortable.
~SAIF/PAIF/Everyone Welcome~
Me= 37 and DH = 41
Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)
IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN
IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.
IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132. Lil is here!
TTC#2: Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.
IVF #4: BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN
IVF #5: MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN
IVF #6: (New RE): Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN
FET#1: BFN
I go to Women and Infants. My RE is also affiliated with Tufts so I have gone there for some of my appointments but all my procedures are at W&I which is close to where I work but I do have the option to go to Tufts. Let me know if you want me to send you their information.
Honestly, I'd do 4 if that's what the RE advised. But it is such a personal decision. It comes down to the fact that DH and I would rather have twins (although triplets or quads, eek) than have another IVF cycle fail.
It comes down to whether you trust your RE, and your comfort level at accepting the risk associated with HOMs, no matter how small it is. Good luck, honey. I hope further discussion brings you some clarity on the issue.
SR with triplets? I didn't know they did that. I really need to talk to my RE. He never mentioned when he would want SR and it was never in the million forms we signed.
That would be much appreciated, thanks ! Do they do ER & ET at each location or do you have to go to one centralized one for the 2 procedures? I just looked on their web-site and it looks like they have an office about 45 min from me.
"Most of the important things in the world have been accomplished by people who have kept on trying when there seemed to be no hope at all." -- Dale Carnegie
"Our greatest weakness lies in giving up. The most certain way to succeed is always to try just one more time." --Thomas A. Edison
Hey Beth! Wow, 4 seems like alot but like Mtomms said, I would talk to him about the difference between 3 and 4. I was going to say put in 3.
Good luck with your appt. Im glad those biotches finally called you back and you are getting things moving!
Wow - that is a really tough decision. If they are thinking there could be a genetic issue have tehy mentioned testing you and YH to see if you are carriers for anything? Or have they mentioned using PGD? Just wondered if there are any other things they can use or rule out b/f going forward with tranferring 4 - just to be on the safe side.
I hope the new protocol helps and that you can get some more answers at your appt today.
A probability as small it is still real and should not be dismissed. Take it from an engineer.
And with that iformation, discuss if you would rather have 4 or 3 babies in the NICU than to have to do another cycle.
And please no need to answer.
I moved to IVF because the thought of triplets took my sleep away. I could not see me through that while being my choice. If one splits in three, I'd go with it.
I think this is one of the hardest decisions of IVF. Good luck sweetie. Talk a lot with your husband.
TTC since 1/2008
They think it is a gene mutation problem. We only were tested for CF and that was through my OB/GYN. My RE does not think it is needed because it wouldn't change what we are doing and he is against PGD because since I only get about 7 eggs he feels that it may jeopardize a good one. IDK. It is so much to take in and understand.