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ANA Positive Question

delphinus12delphinus12
in High-Risk Pregnancy

DH and I plan on TTC in the next few months. I just found out that I am ANA positive (1:160) but negative for the autoimmunes they tested me for.

I have a call in to the OB but I was wondering if anyone has experience with this. I have heard some Dr's recommend taking baby aspirin even when TTC.

Also, once pregnant I'm wondering if the positive ANA is considered high risk in itself (with no autoimmune)? With my first pregnancy I developed pre-e at 40w5d and had an emergency induction. I also had poor blood flow in my right leg and had to do heparin injections for about 2.5 months.

TIA!

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Re: ANA Positive Question

  • farrellashleighfarrellashleigh member

    I was tested and came back with a +ana last pregnancy, they put me on a baby aspirin and lots of growth ultrasounds. Everything was fine during the pregnancy with no complications until my 34 week appt when he fell off of the growth curve. I ended up being induced 2 weeks later, he was born 5#3oz and perfectly healthy but definitely on the small side with a "tiny" placenta.

    The problem with the ana is a risk of clotting which can build up in the placenta and decrease nutrients to the baby, hence growth issues.

    I re-did my bloodwork this time at my last appt. I had a +ana again but now I have multiple autoimmune flags popping up + (lupus anticoag, cardiolipn, rpr, etc) all of these were negative last time. My OB has consulted with the high risk docs and they said that the course of action would be the same as last time, to continue with a daily baby aspirin and to have serial growth ultrasounds. Other than that there shouldn't be any issues. (Of course after I'm done being pregnant I will have a consult with a Rhuematologist to see what is going on)

    Hope that helps, I never had blood circulation issues or any other complications. I'm not sure if the baby aspirin would be recommended while TTC, I'd probably ask your OB about that one.

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  • farrellashleighfarrellashleigh member
    also, the +ANA alone doesn't make you high risk although your OB may wish to consult with a high risk doc throughout your pregnancy.
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  • atalanta04atalanta04
    I am also ANA positive, and negative on the other autoimmune risk factors.  I do have a clotting risk factor though (previous blood clot and protein S deficiency), so I have to be on heparin throughout my whole pregnancy.  I don't think ANA is a risk factor alone, but it is associated with blood clotting issues, and I did read somewhere that it can be related to growth restriction.  I just found out that my LOs growth is a little behind (she's in the normal range, except for her abdomen, which is in the 4th percentile), so now I will be monitored weekly with extra ultrasounds.  At any rate, if you had to be on heparin before, and you are ANA positive, then chances are they will want you on heparin throughout your entire pregnancy (and maybe even while trying to conceive).  I would definitely ask your OB if you should be on something (either aspirin or Lovenox) while TTC, since clotting issues are associated with miscarriage and it's better to be safe than sorry.
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  • delphinus12delphinus12
    Thank you both, this is very helpful.
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  • RevJGRevJG
    Were you specifically tested for SSA antibodies (most commonly found in Lupus and Sjogren's disease)?  The presence creates a risk of congenital heart block in the baby and so you have to be monitored with fetal echocardiograms every other week starting at 16 weeks. 
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  • delphinus12delphinus12

    imageRevJG:
    Were you specifically tested for SSA antibodies (most commonly found in Lupus and Sjogren's disease)?  The presence creates a risk of congenital heart block in the baby and so you have to be monitored with fetal echocardiograms every other week starting at 16 weeks. 

    I believe I was, but I will double check! Thanks! 

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