WWYD: Next IUI Treatment

missjul61 · November 2010

I posted a few days ago about my IUI #2 being cancelled due to producing a few too many follicles. I have been on several Clomid 100mg cycles (all BFN), the first 3 of which were unmonitored under my OB. When I moved on to my RE, he put me on the same dosage for IUI #1 and I produced 3 mature follicles but got a BFN. He put me on the same dosage for round 2 but this time I made 5 mature follies (cancelled).

If you were in my shoes for IUI #2.1, would you a) continue w/ Clomid as the same course of treatment or b) would you try Femara or a very low dose of injectibles? At this point, do you think Clomid just isn't the right drug for me?

Thanks in advance for the input. My next appt isn't until 11/18 so I'm driving myself crazy w/ what if's.

hall_ky · November 2010

Well it seems like you are responding well to the clomid, maybe a little too well. What about trying the clomid again maybe at 50 mg or 75 mg?

Have you ever been on 50 mg of clomid? Maybe you would respond to that w/o over responding?

missjul61 · November 2010

hall_ky:
Well it seems like you are responding well to the clomid, maybe a little too well. What about trying the clomid again maybe at 50 mg or 75 mg?
Have you ever been on 50 mg of clomid? Maybe you would respond to that w/o over responding?

It's so strange that the same dosage produced 3 one round and 5 another. I'm hesitant to go w/ the lower dose as I'm afraid I'll make less than 3 follies thereby decreasing our chances. The optimal # of follies for me is 3. Any more than that is risky and scary!

hall_ky · November 2010

Well if you stay at your present dosage there's a risk of producing too many. Since you haven't tried a lower dose, you don't know how many follies you would produce on it. You could produce 3, who knows...

Just curious, why do you consider 3 the perfect amout of follies?

Rachael07.07.07 · November 2010

I also think you should try a lower dosage. Especially if the first cycles were unmonitored. You don't really have a true gauge of the avg follies you've been producing. I would try one or two more cycles at a lower dosage and see how things go. I'm also curious as to why 3 is the optimal number for you?

missjul61 · November 2010

3 is the optimal number for me because that is the max I think my RE would proceed w/ another IUI w/out talking me out of it like he did this round. Also, the possibility of triplets scares me but I think I'd risk it w/ 3 follies to up my chances of conceiving 1 or 2. Risking having 4 or more is out of the question though.

missjul61 · November 2010

Rachael07.07.07:
I also think you should try a lower dosage. Especially if the first cycles were unmonitored. You don't really have a true gauge of the avg follies you've been producing.

You make an excellent point.

etoyama · November 2010

Rachael07.07.07:
I also think you should try a lower dosage. Especially if the first cycles were unmonitored. You don't really have a true gauge of the avg follies you've been producing. I would try one or two more cycles at a lower dosage and see how things go. I'm also curious as to why 3 is the optimal number for you?

ITA. GL!

KDR1979 · November 2010

Normal semen analysis?

Have you had an hsg to make sure tubes are open?

Is the Clomid 100mg making your lining too thin?

If the SA is normal and your tubes are clear, I would also try going back to Clomid 50mg. Clomid made my lining too thin, but I did great on Femara.

Good luck!

missjul61 · November 2010

KDR1979:
Normal semen analysis?

Have you had an hsg to make sure tubes are open?

Is the Clomid 100mg making your lining too thin?

If the SA is normal and your tubes are clear, I would also try going back to Clomid 50mg. Clomid made my lining too thin, but I did great on Femara.

Good luck!

- Normal SA - Tubes are clear - Lining is a bit thinner on 100mg but still in the good range Thanks ladies! I will go with the lower dosage.

missjul61 · November 2010

KDR1979:
Normal semen analysis?

Have you had an hsg to make sure tubes are open?

Is the Clomid 100mg making your lining too thin?

If the SA is normal and your tubes are clear, I would also try going back to Clomid 50mg. Clomid made my lining too thin, but I did great on Femara.

Good luck!

- Normal SA - Tubes are clear - Lining is a bit thinner on 100mg but still in the good range Thanks ladies! I will go with the lower dosage.

missjul61 · November 2010

KDR1979:
Normal semen analysis?

Have you had an hsg to make sure tubes are open?

Is the Clomid 100mg making your lining too thin?

If the SA is normal and your tubes are clear, I would also try going back to Clomid 50mg. Clomid made my lining too thin, but I did great on Femara.

Good luck!

- Normal SA - Tubes are clear - Lining is a bit thinner on 100mg but still in the good range Thanks ladies! I will go with the lower dosage.

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