Having second thoughts over my PGD decision....

jcath · October 2010

My RE recommended doing a genetic testing on cells from my embryo's at a lab in Detroit - so after egg retrival they will send a cell from each embryo to the lab and all 23 chromosomes will be looked at to see if there is a deletion or an extra. Meahwhile they freeze all the embies waiting on the results and we do a FET the following month.

I'm really having second thoughts about missing the opportunity to do a fresh transfer. The RE's office does PGD on about 9 chromosomes in house and does a 5 day fresh transfer - I know it's not as comprehensive but the risks of the FET just freak me out. I asked the nurse to have the Dr call me to discuss. On the one hand I think if he recommended it - he probably knows best but I just can't shake the feeling that not attempting a fresh transfer is a bad idea.

njohnson1972 · October 2010

How many embryos do you typically make? Why are you doing the PGD to begin with?

I only get 4-5 per IVF cycle, so I can't really afford to do a FET. Plus, I don't make great eggs.

If I made lots of great eggs, then I wouldn't question the PGD.

Edwina.McDunnough · October 2010

"If I made lots of great eggs, then I wouldn't question the PGD."

ditto.

labbylover03 · October 2010

What is your doctor's reasoning for the PGD?

We are also doing PGD for my DH's balanced translocation so they are specifically screening for that...but we can opt for additional chromosomes to be tested as well. We are using a lab in NJ and are able to do the biopsy and get the results by Day 5 for my transfer. I hope after discussing with your doctor more, you will be comfortable with your decision b/c in the end, it is your decision on how you proceed.

Best of luck! I'm so sorry we even have to make decisions like this!

jcath · October 2010

This is my first IVF so I don't have a history to determine how many eggs I'll get. My antral follicle count was 34 and today at my CD 5 appt I had 7 measurable follies so I think I'm going to get a good number. The only reason we're doing it is my age (40), I had a second trimester miscarriage recently, and my dx is unexplained so the Dr. thinks maybe there is a genetic component.

labbylover03 · October 2010

jcath:
This is my first IVF so I don't have a history to determine how many eggs I'll get. My antral follicle count was 34 and today at my CD 5 appt I had 7 measurable follies so I think I'm going to get a good number. The only reason we're doing it is my age (40), I had a second trimester miscarriage recently, and my dx is unexplained so the Dr. thinks maybe there is a genetic component.

Wow! That's a great AFC! Looks like you're off to a great start! Best of luck! And again, I'm so sorry for your loss.

SunMoon&Stars · October 2010

First....I'm very sorry about your loss. Second....I hope you don't feel like you're second-guessing your RE. I'm sure he has a valid reason for recommending PGD, but you're entitled to understand it. That's your right as a patient, so you were right to request clarification. I hope you get the answers you need;keep us posted.

Nature Lover · October 2010

This has to be a very personal decision - like every other one relatedf to IF and noone (including your RE can tell you what to do). I offer this only as ONE perspective. If my RE recommended it I think I would do it. My body has chosen not to make a baby or keep a baby for some reason or the other. I have to wonder if I have been pregnanat without even knowing it and my body terminated teh pregnancy due to genetic issues with the embryo. I don't know that, but I wonder that. You have to ask yourself how you would feel if you had a baby with some genetic abnormalities after trying to hard to get PG. Obviously you wouldn't prefer that, but could you handle that? How would your life change? I have a brotehr iwth multiple disabiliteis, and I work with people with disabilites. Many of them live very full lives. Many otehrs endure endless suffering. I don't think I'm strong enough to be a parent to a child with so many challenges and watch them suffer.

What about genetic testing before IVF? My doctor recommended that and we are using an online company that sends you a kit and you do a saliva test and FedEx it back. It's $350 and my insurance covered all but $50. Tests for hundreds of genetic mutations - but somet hings aren't covered, like for example I don't hink it tests for Downs Syndrome. Maybe wroth checking out. https://www.counsyl.com/

611bride05 · October 2010

Can you double check with your RE and see if there are any other labs you can use that will test all the chromosomes in time for a fresh cycle? There are 2 that my RE uses, and DH and I are deciding over the weekend which one to go with. They both test all 24 chromosomes in time for a 5 day transfer. Reprogenetics and GSN are the 2 that we are deciding between. They aren't cheap but after multiple losses we are willing to pay the price.

Good luck to you!

buddingflower · October 2010

I'm sorry for your loss. I understand you not wanting to miss an opportunity to transfer during a fresh cycle. One thing to consider is that some REs feel the body is more receptive during a FET cycles because the body's not full of meds. I personally have not had success with either, so I can't attest to that. I would say that my second IVF yielded 8 embies. We transferred 2 and froze 6. I have had good thaw rates for each FET as we have not lost an embie yet. We will do PGD next time if I have to do IVF again. Remember it's a personal decision, but don't rush a transfer because of impatience. If you have a good fert rate, I would strongly consider following your RE's reccommendation. You much rather do it now than later (If needed, let's hope it's not

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