Infertility

ET - what's the max that you'd put in?

I'm looking for suggestions/thoughts/comments...whatever.....

So for my two previous (failed) IVF's, I never had a choice regarding how many to put in.  I only ended up with 2 on day 4 (IVF 1) and 2 on day 5 (IVF 2).  So we put in 2 each time. 

This time the RE recommends a 3 day transfer.  Most of my mature eggs didn't fertilize.  I'm 36, this is my last IVF and I apparently have a major egg quality issue (1 previous pregnancy lost due to chromosomal abnormality)and DOR.

As of today, I have 4 4-celled embryo's that are growing well.  A few others that are still 2-celled.  Who knows what tomorrow will bring.

Would you put 4 in?  My RE says definitely 3 and 4 is a possibility....but she wants me to think about it and decide tomorrow. 

This is my last IVF attempt so a singleton would be a dream, but I'd love to have any amount of kids.  I've always wanted a big family.  Finances are not a problem.  It is the safety of it all that is my concern.

Thoughts?

Re: ET - what's the max that you'd put in?

  • It such a personal choice - so many factors to weigh in. So - here is my simple opinion

    If it was me, if I were 36 and this were my last IVF after 2 previous failed IVFs and the ET was on day 3, I would transfer 3. 

    Married 08.06
    Started TTC 05.08
    Me: Stage II endo, borderline high FSH
    DH: perfect
    1 lap, 5 IUIs = 4 BFNs and 1 c/p
    2 IVFs, 2 FETs = 1 BFN, 1 c/p, 1 ectopic and finally a sticky BFP in May 2011!

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    1 FET in Aug 2013 = BFP! 

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  • Obviously it has to be your call. But 4 scares the crap out of me! I think 3 might be a good option if your RE recommends it, and if you are ok carrying triplets should they all implant and stick. I think you have to be ok with the possibility of the financial and emotional toll of triplets/twins too, but you said that you are ok there. I would just be really concerned about carrying 4 babies-That's how I see it anyway!

    GL with whatever you decide though!

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  • My max in your situation would likely be 3.

    Best of luck with whatever you choose!!

    Crohn's resulting in colectomy with J-Pouch surgery in 2000/2001.
    TTC since August 2008
    IVF#1: BFFN; IVF#2: BFN; FET with new RE: BFN
    IVF#3: ER 1/15; ET 1/20; Beta#1 1/29: 339!
    Twins girls born via c/s at 37w/3d!!
    "Let it go, this too shall pass."
  • For my first IVF at 38, we had four embryos, but only two were decent.  Two were only 4 cell on day 3. My RE recommended we transfer all four. He said that at my age, the chance of triplets was about 1%.  We were open to SR if necessary, however, although I would have hated to be put in that position. I don't think you can make the decision until you see how they are doing tomorrow. If all four are 8 cell, I would only transfer three. If they aren't that strong, then I would consider four.
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  • I may be crazy, but if it were my last attempt and I had zero implantation on 2 prior transfers of 2, I would probably do 4.  But, I guess it may also depend on the quality of the embies on day 3 of this cycle versus day 3 of the prior cycles.  If they are all doing better, then I may only put 3 back. 

    With your history, I would think it would be a very low possibility that all four would stick (or for that matter, even 3).  I did a day 5 transfer of 2 expanding blasts on my first IVF cycle (which didn't work).  At that point my RE was willing to transfer all 3 of our day 5 blasts.  Since it was our first cycle and all three blasts were high quality, I wasn't comfortable with transferring more than 2.  With the next cycle, I may be willing to transfer 3.  Since my clinic does day 5 transfers, I don't think I would do more than 3.

    Good luck with your decision and with the rest of your cycle!

    imageimage


    ~SAIF/PAIF/Everyone Welcome~ 

    Me= 37 and DH = 41 

    Dx: DOR, Endo, APA+ (really high beta 2 glycoprotein antibody and high everything else tested), heterozygous MTHFR mutation, positive for lupus anticoagulant, high FSH, low AMH and both tubes blocked (per HSG on 3/8/11)

    IVF #1 - long lupron (with HGH, intralipids, lovenox and BA); 4 retrieved, 3 fertilized; ET 2 blasts and 1 frozen = BFN

    IVF #2 - a version of antagonist with EPP (with HGH, intralipids, lovenox and BA); 6 retrieved, 4 mature, 3 fertilized, 2 blasts and 1 frozen blast transferred on day 5 = BFN.

    IVF #3 April was postponed to May, May was canceled. June/July was canceled. Had a cyst aspiration and then began IVF #3 in August. ER on 8/22; ET on 8/24 with AH. +HPT on 9/5. Beta #1 (11dpo) = 3; Beta #2 (15dpo) = 29; Beta #3 (17dpo) = 60; Beta #4 (19 dpo) = 118. Heartbeat at 6 weeks 6 days =132.  Lil is here!

    TTC#2:  Trigger + TI = BFN; Clomid + Trigger + IUI = BFN.

    IVF #4:  BCP + MDLF + Lovenox = 7R, 1F = Transferred 1 6-cell embryo on day 3 = BFN

    IVF #5:  MDLF + Lovenox = 4R, 1F = Transferred 1 10-cell compacting embryo on day 3 = BFN

    IVF #6:  (New RE):  Long Antagonist November 2014 (transferred two 8 cell grade 1 embryos and froze one blast) = BFN

    FET#1:  BFN

  • It depends on the embryo grading on cd3, no way to judge without that information.

    But I am AMA also, and if this were my last stab at IVF with 2 failed previous cycles, I would lean toward being aggressive.

    Good luck in your decision.

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  • I think it is a personal choice.  I'm 29 and my max is 2.  With this upcoming FET, we are considering transferring 1 because I'm deathly afraid of having twins (we can't afford twins).  I get pregnant with each transfer so getting pregnant isn't the issue, finding the sticky embryo is.  So, personally I'm okay with trying 1 for a cycle and seeing what happens. Of course I realize that this may sound risky and silly to some other people, but we are strongly considering it.
    TTC #1 and Only Since August 2008 DH: Severe Male Factor Infertility (Diagnosed July 2009) Me: Clean bill of health 2 IVF w/ICSI cycles + 2 FET = 3 BFP = 3 Chemical Pregnancies FET #2 = BFN Tired of IVF - Trying for a miracle with IUI IUI #1 - 1.1 Million Motile = BFN Surprise Natural BFP on 1/10/12...Praying this is our take home baby
  • If I were you I'd probably transfer 4.  I would think the percentage of quads would be very low - my RE told me if IF I get KU, the chance of trips w/ transferring 3 is only 5-8%.  Since it's your last IVF, you're 36, and you have known egg-quality issues, I'd be more agressive and do 4.

    TTC in 2008. Stage II/III endo, Hashimotos hypothyroid, low morph (3%).
    2 cycles Clomid/Ovidrel/TI/Crinone=BFN.
    IUI #1 - 4 Follistim/Ovidrel/IUI/Crinone = BFN.
    IVF #1 - Antagonist w/ ICSI 4/10. 17 retrieved, 5DT of 2, BFN :(
    IVF #2 - Long Lupron w/ ICSI 6/10. 15 retrieved, 3DT of 2, BFFN!!
    Lap 7/21/10
    IVF #3 - Clomid/Antagonist w/ ICSI 10/10. 14 retreived, 3DT of 3, BFP 10/20 but m/c. No HB 11/15/10 - D&C 11/17/10.
    FET - 2 blasts, 1 survived the thaw. Transfer 2/19. Beta #1 3/1 375, Beta #2 3/3 885, Beta #3 3/8 4261, Beta #4 3/11 9005. U/S 3/8 1 sac 1 yolk, U/S 3/16 1 heartbeat 114bpm!

     

    James born Oct. 24th 2011 via c-section at 38 weeks!

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    Surprise BFP - Jack born April 28, 2013 via VBAC after PTL at 33 1/2 weeks!

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  • Thanks for all of the comments.  They all make sense to me, which is the crazy part!

    I can't wait for my husband to come home so we can have this discussion.  I wish I had more time to think about it. 

    Thanks again.  I'll post tomorrow after the transfer. 

  • imagehollymichael:
    For my first IVF at 38, we had four embryos, but only two were decent.  Two were only 4 cell on day 3. My RE recommended we transfer all four. He said that at my age, the chance of triplets was about 1%.  We were open to SR if necessary, however, although I would have hated to be put in that position. I don't think you can make the decision until you see how they are doing tomorrow. If all four are 8 cell, I would only transfer three. If they aren't that strong, then I would consider four.

    This exactly. 

    TTC since 8/2004
    Me - DX Hashimoto's Disease, Hypothyroid, Rheumatoid Arthritis
    DH - DX Azoospermia - Sertoli Cell Syndrome
    DS-IUI #1-4 BFN IVF #1 - BFP! It's a boy!!!
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  • This is our first IVF and we are transferring 3.. Two Grade A and 1 grade B... I think you should go for it! I am and have no plans for triplets, just better odds for One or two!
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  • This is such a hard call to make. It seems like everything in your case is pointing towards transferring all 4, especially if you are ok with the possibility of multiples. Good luck and I hope you come to a decision you and YH are comfortable with!
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  • Like previous posters have said that is a personal decision. But if I were placed in your shoes, I would transfer 3. 4 way scares me more than I want to even think about... 3 I would be very comfortable with. Good luck with whatever you decided. It will be the right decision because you came to it together as a couple :)
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