Any PGD ladies?

Ren's bride · February 2010

Since my miscarriage was due to a chromosomal abnormality, we decided to have pre-genetic diagnosis done on our eggs this cycle so that we have a better chance of transferring chromosomally normal ones. So I'm just wondering what experiences any of you had. I'm mostly worried about how many of the 8 tested will actually be found to be normal, and also that those findings are accurate and not that a normal cell was pulled but in actuality one or more of the OTHER cells would have shown the egg to be abnormal. My transfer is tomorrow so I guess my nerves are just building up now cuz it's so close...

Echloe · February 2010

I thought about doing it but decided the week before ER that it wasn't for us because we wanted to give all of our embryos a chance regardless of their chromosomal normality. I just hope the ones we transferred are o.k.

Anyway, good luck. I think all the cells should be the same (genetically) so you aren't likely to have one show normalcy when the rest in the embryo are abnormal.

Ren's bride · February 2010

In our case the abnormality wasn't one that would have resulted in me delivering a live (for lack of a better word) baby. Our baby had a heart defect--the baby's heart was pumping fluid back into itself instead of out.It's whole tiny body was swollen with all of this fluid that shouldn't have been there. The baby would have continued to grow until I either miscarried naturally or it died inside of me and then I would have had a stillbirth. Doing PGD this cycle will hopefully keep us from being in that situation again.

Echloe · February 2010

Ren's bride:
In our case the abnormality wasn't one that would have resulted in me delivering a live (for lack of a better word) baby. Our baby had a heart defect--the baby's heart was pumping fluid back into itself instead of out.It's whole tiny body was swollen with all of this fluid that shouldn't have been there. The baby would have continued to grow until I either miscarried naturally or it died inside of me and then I would have had a stillbirth. Doing PGD this cycle will hopefully keep us from being in that situation again.

I was in no way judging you. Just saying why we backed out of PGD at the last minute. Anyway, I really hope that PGD works and they find more than a few normal embryos so that you can even go for siblings later on if you want. Best of luck to you.

yodasmistress · February 2010

We did a type of PGD. On our second cycle, 2 of 4 blasts were normal and on our third cycle 4 of 6 blasts were normal. I've heard that 50% normal is "average" for a woman in her early 30s.

ETA ---> since our testing was done on blasts, they take 8 cells to minimize error associated with mosaicism.

bridebahama · February 2010

we backed out of PGD at the last minute too. Mainly b/c not all of our embryos were suitable and we didn't want to risk our two best embryos. It is a risk, you're right, b/c they can pull a cell that looks normal, but it could be a mosaic. Our clinic takes 2 cells to make sure that doesn't happen, but some places still rely on 1. I think you just have to have faith that if an embryo continued to grow and looks good on day of ET and tested fine, it probably is. I know it's scary b/c it isn't a guarantee. ((hugs))

Ali212 · February 2010

Hi-we did PGD during our IVF cycles largely for the same reason. I had a m/c before starting IVF and when they tested the tissue, learned it was a chromosomal abnormality. I never would have had a viable pregnancy and so we went with PGD to ensure the embryos we transferred back were at least the strongest and most viable for a live birth.

My 'normal' embryo rate after PGD was around 25-30% of my fertilized embryos. I think that's on the lower side, that's what my RE said. He said he likes to see closer to 50%. We also did ICSI due to MFI (low morph) and low egg count (they got 8 eggs from me so ICSI gave me a high fert rate which was key given the 2 factors not working in my favor - low eggs and low morph). I would strongly recommend PGD if you can swing it...it at least helped me with my comfort level. GL!

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