MTHFR gene

raindrops · January 2010

I just found out I have the MTHFR gene mutation. I don't have a lot of information about my particular case right now, I just found out last week. I am waiting to see my specialist to get more information. Anyone have this? If so, what information can you give me or any questions for my Dr.?

Thanks!

MrsMSG · January 2010

To be as far along in your pregnancy without any complications thus far is good. Usually, the MTHFR gene is most often blamed for early m/c. I think your dr will be able to put your mind at ease next week. I'm not even sure there would be any regimen they'd put you on at this stage (being, for example, extra folic acid).

monica92603 · January 2010

there are different mutations so it is very important to find out which one you have. It is also very important to have the do another blood test to check your homocysteine levels. This SEEMS to be the tell tale sign as to if it can cause issues/miscarriages. There is a lot of controversy out there about how/if/when to treat it.

That being said, I have a single mutation MTHFR C677T. My homocysteine levels are normal. It had nothing to do with my loss last year. Depending on which form you have, there are different ways to treat it. If that is the only thing that showed on your blood work it is very very treatable. Your OB might tell you to take extra folic acid or baby aspirin. If you have a double mutation, they might recommend blood thinner shots during your pg.

Try not to worry too much. There are TONS of ladies on the boards who have it in one form or another and have had bunches of healthy babies

Good luck!

monica92603 · January 2010

LOL! I didn't even see your ticker. OOPS!

At this point they may just monitor you very closely to make sure your baby's growth is on target and the placenta is doing it's job.

raindrops · January 2010

MrsMSG:

To be as far along in your pregnancy without any complications thus far is good. Usually, the MTHFR gene is most often blamed for early m/c. I think your dr will be able to put your mind at ease next week. I'm not even sure there would be any regimen they'd put you on at this stage (being, for example, extra folic acid).

I did have one early m/c a year ago, my OB mentioned this may have been the cause. During my first pregnancy at 38 (4 years ago), my ob (different ob) at that point did some bloodwork regarding clotting disorders (my mom has a disorder). I was told the blood test were fine and not to worry. I delivered my daughter with no problems. I am also curious as to why this was not found then.

Dobie_Mama · January 2010

monica92603:
there are different mutations so it is very important to find out which one you have. It is also very important to have the do another blood test to check your homocysteine levels. This SEEMS to be the tell tale sign as to if it can cause issues/miscarriages. There is a lot of controversy out there about how/if/when to treat it.

Ditto this. I am homozygous and have normal homocysteine levels. Because of this, my hematologist has only suggested extra folic acid & B vitamins, plus a low dose aspirin. Like the PP said, some doctors base treatment on the homocysteine levels, rather than just the MTHFR, but the treatment plans are controversial and all across the board.

Like you, I did not know about the MTHFR with my first pregnancy. My DD was born via c/s at 38 weeks due to breech presentation, low amniotic fluid, & IUGR. The OB who delivered her felt that the low fluid/IUGR might be related to a clotting disorder. We did testing over the summer and here we are.

AlpacaBunny · January 2010

I have the homozygous mutation and I also have another blood clotting disorder, so my RE had me on lovenox injections through my pregnancy and an rx folic acid.

emmalil · January 2010

I have a mutation of that gene too. In my understanding, they only learned about this mutation in the last few years -- and blamed it for a lot of blood clots and miscarriages, and put everyone on blood thinners. But they've since learned that mutations on the MTHFR gene are very common (my MFM said up to 50% of the population has a mutation) and that if your homocystein levels are normal your risk of clots isn't elevated. If your doctor is particularly worried about it, I would get a second opinion, since I had a midwife who wasn't up on the literature and got me all freaked out.

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