Pregnant after IF

crinone question

My friend just contacted me that her progesterone level on crinone is 6.5 has anyone had such a low number on it? she is 4 weeks and has been through cancer etc so I am so worried for her.
6 m/c
Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
1 Clomid/Ovidrel BFN May 2011
Natural cycle Aug 2011 BFP M/C 4 Weeks
1 IUI Sept 2011 BFP M/c 7 weeks
Provera Dec 2011 BFP M/C 3 Weeks
DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
Went to Beer Center- high tnf, low lad, implantation failure
Nov/Dec 2012 LIT Treatment
Dec 12 Humira
Jan 2013 BFP
Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
Miracle Born August 2013 Premature

Yours doesn't have to be a sad story



image
image


Lilypie - (ugiy)


Re: crinone question

  • I might be totally wrong, but I thought when you're on crinone it doesn't really matter what the level on the blood work says because the crinone makes sure the progesterone gets where it needs to go!
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  • imageStephiemae22:
    I might be totally wrong, but I thought when you're on crinone it doesn't really matter what the level on the blood work says because the crinone makes sure the progesterone gets where it needs to go!

    Thats what they told her but to have a succesful pg she should be 15 or above for a medicated IVF cycle according to our m/c specialist 

    6 m/c
    Anovulatory cycles, increased Synthroid Diagnosed Sep 2010
    Natural cycle Dec 2010 BFP M/C 6 1/2 Weeks, D&E Jan 2011
    1 Clomid/Ovidrel BFN May 2011
    Natural cycle Aug 2011 BFP M/C 4 Weeks
    1 IUI Sept 2011 BFP M/c 7 weeks
    Provera Dec 2011 BFP M/C 3 Weeks
    DQ ALPHA HLA MATCH, High NK Cells Diagnosed Dec 2011
    IVF March 2012 BFP m/c 4weeks 5 days (IL, Prednisone)
    IVF#2w/DS July 2012 MEGA FAILURE BFN (IL, Dexamethasone)
    Diagnosed No real HLA Match, DQ Beta Triad, High TNF, Low NK Cells
    Oct 2012 Natural Cycle m/c 4wks (Lovenox, Prednisone) 
    Went to Beer Center- high tnf, low lad, implantation failure
    Nov/Dec 2012 LIT Treatment
    Dec 12 Humira
    Jan 2013 BFP
    Humira,LIT,Prednisone, Lovenox, IVIG, Baby Aspirin
    Miracle Born August 2013 Premature

    Yours doesn't have to be a sad story



    image
    image


    Lilypie - (ugiy)


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  • jadweddjadwedd member

    Did they mention trying the injectable kind (pio) ?  It seemed to work well for me and it keeps the levels up.  I will keep her in my prayers.

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  • imageluvboston:

    imageStephiemae22:
    I might be totally wrong, but I thought when you're on crinone it doesn't really matter what the level on the blood work says because the crinone makes sure the progesterone gets where it needs to go!

    Thats what they told her but to have a succesful pg she should be 15 or above for a medicated IVF cycle according to our m/c specialist 



    I was put on Crinone when my progesterone dropped below 15, and by the next appointment there was a noticable difference in my bloodwork. If I was her, I would inquire about increasing dosage or switching to PIO to be safe. Better safe than sorry!
    TTC #1 since Oct 2009, Dx: Unexplained Infertility
    HSG: Right tube all clear, left tube inconclusive
    3 failed Clomid Cylces
    4/5 lap revealed blocked left tube, but right tube is open
    April/May- 50 mg Clomid + Ovidrel + IUI #1= CANCELLED left ovary ovulating
    June 1- 100 mg Clomid + Ovidrel + IUI #1 = BFN
    June 28- 100 mg Clomid + Ovidrel + IUI #2 =BFP!
    7/12 Beta #1= 14 Beta #2= >5 Chemical Pregnancy :(
    July-Nov long break to recover emotionally and financially
    Nov 24- 100 mg Clomid + Ovidrel + IUI #3= BFN
    Jan 22- Gonal-F + Ovidrel + IUI# 4 = CANCELLED no response on right
    IVF #1- Start stims 4/7, ER 4/20, 21R, 14F, 6 frosties, ET 4/25, 2 embryos transferred= BFN :(
    FET #1- June 2012, Lurpon starts 5/27- CANCELLED
    FET #1 take 2- August 2012, delayed until Sept-CANCELLED
    FET #1 take 3- ET 10/11, 2 embryos transferred,= BFFN
    FET #2- Transfer 12/4--Cancelled, no embies survived thaw :(
    Next steps-- IVF #2 with new RE in March
    HOLY SURPRISE BFP 2/15/13!!!! Beta 1- 286, Beta 2- 782, First Ultrasound 2/25- baby in uterus & all looks good!


    BabyFruit Ticker

  • mnj05mnj05 member

    I don't know what my levels were before crinone as I started it immediately, but I can tell you I wasn't allowed off of it until my progesterone was at 30. Yes, the levels could be a little different than shown in the blood work, but from what I've been told, it doesn't vary too much. She might need to inquire about something different.

     imagePhotobucket

    TTC #1 since 3/2011
    DX: anovulatory and severe MFI
    DH is a testicular cancer survivor
    IVF#1 w/ICSI lupron, gonal f, ovidrel
    ER 6/15/12 6R 6M 6F! ET 6/20/12
    Beta #1: 154 Beta #2: 509 Beta #3: 7326
    Baby Boy born 3/1/2013
    Baby Birthday Ticker Ticker

    TTC#2: 6/2014 all testing came back normal

    IVF#2 (#1 for LO#2) 9/2014 - 17R 10M 10F 4 blasts frozen on day 6.

    FET #1 10/15/14 - Beta #1: 216  Beta #2: 823


    Baby Boy born 7/10/2015


  • I agree. I would be worried. It's true that not all the progesterone she is receiving vaginally will be reflected systemically in the circulation, but even if this were an unmedicated cycle, she'd want her natural progesterone production to be above that level.
    IUIs #1-3 (1x unmedicated, 2x Clomid) = 2 BFNs, 1 m/c at 7w3d
    IUIs #4-6 (injects) = 3 BFNs
    IVF #1 = BFN
    FET #1 = BFN
    FET #2 = BFN
    IVF #2 = BFP, b/g twins lost at 20w due to partial abruption/PPROM
    IVF #3 = c/p 5w2d
    Long-shot Clomid/Prednisone cycle before next IVF = BFP, our beautiful, healthy girl born 6/26/13!
    ~~
    TTC again March 2014
    FET #3 - May/June 2014
    -
    all embryos arrested before xfer - back to the drawing board...
    IVF #4 - July/August 2014 
    beta 1 (11dp3dt) 220, beta 2 (13dp3dt) 671, beta 3 (19dp3dt) 10762
  • imageluvboston:

    imageStephiemae22:
    I might be totally wrong, but I thought when you're on crinone it doesn't really matter what the level on the blood work says because the crinone makes sure the progesterone gets where it needs to go!

    Thats what they told her but to have a succesful pg she should be 15 or above for a medicated IVF cycle according to our m/c specialist 

    We were told this as well.  

    She should ask about something stronger than the gel.  PIO might be best for her at this point. 

    http://oi58.tinypic.com/nqv6fk.jpg

    DX: PCOS/Recurrent losses/MTHFR mutation (compound hetero)
    5 hysteroscopies/2 surgical
    3 Inject IUIs = 2 m/c's and 1 BFN
    IVF #1= BFP. m/c at 7w6d. Needed 2 D&C's and scar tissue removal. Mild OHSS
    IVF #2 = BFP. Severe OHSS. 4 Drainings. TWINS!
  • crinone does NOT show up in bloodwork... or barely any of it because of the delivery system.  My RE never bothered to test my P4 until I switched over to PIO
    TTC #1 Since 4/2010, Cycle 30
    Positive for HLA-B27, I'm a mutant :p
    Testing - Me ok, gluten issue? DH - borderline count, low motility
    4/28/11 IUI#1 = BFP!(5/25), EDD 2/2/12 - m/c 5w3d
    7/3, 7/31, 9/25 - IUI#2-4=BFN
    IVF#1 - 1 blast = BFP!! (12/30), EDD 9/9/12, confirmed c/p 4w2d
    FET#1 3/2/12 - 2 blasts =BFP!! EDD 11/18/12, us#1 = twins! Confirmed m/c 5w6d
    4/20-surprise BFP and another c/p 4w2d
    FET#2 7/16/12 - 2 blasts = BFN
    FET#3 8/20/12 - 1 blast - BFP!! Beta #1-2=177, 354
    1st u/s 5w6d, one beautiful little HB :), 2nd u/s 146bpm
    baby girl born 5/10/13

    TTC#2 since 12/17/2014, Cycle 8
    Repeat Testing...FSH=12, AMH=3.8, AFC=28. 
    IUI#5 5/10/15- c/p?
    IVF#2 8/19/15 - cancelled due to cysts
    IVF#2 take two 10/2015 - 5 blasts frozen
    FET#4 12/11/2015 - BFN - 4 blasts remaining
    FET#5 2/18/16 - BFP!!!  Beta1-3, 126, 250, 745!!

    Image and video hosting by TinyPicLilypie Angel and Memorial tickers

    Tons of love and ((hugs)) to my IF sister NMscubagirl


  • imageGregermis:
    crinone does NOT show up in bloodwork... or barely any of it because of the delivery system.  My RE never bothered to test my P4 until I switched over to PIO

    This is what I thought too.  I would request the PIO if I were her at least for peace of mind.

    Me- 32, DH- 32- TTC for 4 Years
    IUIs 1-6 BFN
    IVF #1= BFP- M/C
    FET- Beta#1: 69, #2: 482, #3: 1088, #4: 28,318, Ultrasound- 1 beautiful heartbeat
    It's a boy!

     BabyFruit Ticker

  • imageGregermis:
    crinone does NOT show up in bloodwork... or barely any of it because of the delivery system.  My RE never bothered to test my P4 until I switched over to PIO

    This! My RE did do b/w to test progesterone, but said don't be alarmed if it comes back lower than you think because Crinone does not show up in bloodwork.

    TTC #1 since 6/2010
    8 IUIs - 3 Cancelled cycles - 1 Ectopic Pregnancy with Left tube removal = A broken heart
    IVF #1 : Fall 2012
    15R - 13M - 13F w/ICSI - Transferred 2 day 5 blasts = BFP!!!
    8 Frosties!
    Beta #1: 135, Beta #2: 312, Beta #3: 996
    10/21: Saw one beautiful flickering heartbeat! EDD: 6/12/13
    ?S/PAIFW?

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    imageimageBabyFruit Ticker

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