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Infertility
IBackBevo
member
May 2014 January Siggy Challenge:
XP: Anyone here a fragile X premutation carrier? (pic/siggy warning)
IBackBevo
member
in Infertility
I posted this on the Success After IF board, but didn't get a response so thought I would try here as I am really interested to hear someone else's take on this who is in my same shoes...if there is anyone else out there...
I am a fragile x premtuation carrier which is what caused my DOR...this is closely associated with DOR and POF. The other day, I came across this interesting article/study:
https://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033638
A quote from the article reads: "Known associated with low FOR (functional ovarian reserve) at young age, het-norm/high, thus, appears to preserve FOR into older age, and both het sub-genotypes appear to expand female reproductive lifespan into opposite directions."
In plain English, I took from this article that being FX premutation carriers is associated with infertiliyt/subfertility at younger ages, this mutation is also associated with having better fertility at older ages. I'm taking from this that maybe the DOR issue in Fragile X premutation carriers is an issue with the recruitiment of eggs (thus the low AMH/High FSH) and perhaps not truly indicative of a true low ovarian reserve...in otherwords the high number of repeats somehow inhibits our ability to recruit eggs so that we always recruit fewer eggs (or hardly any eggs) our entire life, but this, in turn, leads to actually having more eggs later in life. This is just my "analysis" but I wanted to share and see what anyone else thought...
I was wondering if anyone else had heard anything about this or knew anything about this. I would love to hear your thoughts or hear if your RE knows anything about this. I am not currently under the care of an RE, but when I was he seemed to know next to nothing about being a FX premutation carrier affected my fertility other than just to say it was probably what caused the DOR.
IF DX: DOR & Fragile X pre-mutation carrier
2011: FSH 13.3 & E 99; AMH 0.54 2nd FSH 6.2 E 40's AFC: 8
BFP from Clomid/IUI ~ Pre-e and IUGR during pregnancy ~ DS born 9/4/12
Feb./March 2013: AMH less than 0.16 (undectable) and AFC = 4;
BFP from supps ~ DS#2 due May 2014
2011: FSH 13.3 & E 99; AMH 0.54 2nd FSH 6.2 E 40's AFC: 8
BFP from Clomid/IUI ~ Pre-e and IUGR during pregnancy ~ DS born 9/4/12
Feb./March 2013: AMH less than 0.16 (undectable) and AFC = 4;
BFP from supps ~ DS#2 due May 2014
May 2014 January Siggy Challenge:
This discussion has been closed.
Re: XP: Anyone here a fragile X premutation carrier? (pic/siggy warning)
but I wanted to let you know I have heard of it!