Infertility

Article on pros and cons on twins

https://www.webmd.com/baby/features/twins-demand-through-ivf

After my failed IVF #1 DH and I have been discussing if we should transfer 1 or 2 embryos for our upcoming FET. Ultimately I am going to see what my doctor recommends but this is a good read.

Also what have the rest of you decided on transferring after a failed cycle and why??

Sorry I am full of what if'sConfused and like to hear others thoughts.







      


 TTC since 9/10 consult 1/12 All testing came back fine Diagnosed with Unexplained infertility -3 medicated IUI's All BFN IVF - ER 11/14 24R, 15M, 13F ET 11/19, BETA 11/28 BFFN --Next step FET in Jan ET scheduled for 1/24. Beta #1 350 Beta #2 735. U/S Hell. miscarriage D&C at 9weeks. FET #2 ET 5/28 cancelled FET# 2.5 6/26 ET Beta 7/5 302 7/7 Beta #2 632 Everyone welcome



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Re: Article on pros and cons on twins

  • we struggled with this too. particularyl because i ended up with a SCH before my m/c.

    considering we put in two last time, had only one develop that eventually miscarried we decided to put two back in for our FET yesterday. 

    our goal was to end up with one healthy baby. part of our reasoning is I am 33, so we don't feel as though we have a ton of time left. 

    TTC #1 since 12/2010 DH: MFI, cancer survivor Me: Resected septate uterus, lap treated mild endo, tubes open, ovulate on own, autoimmune disease 3 Failed IUI's (2/2012, 4/2012, 6/2012) 
    IVF #1 August 2012. BFP! Beta #1 56.7 Beta #2 150 One baby, one heartbeat on 9/20/12! no h/b @7w6d. dandc @8w0d
    FET #1 December 2012, BFN
    FET #2 February 2013, no embies survived thaw
    IVF #2, BFP #2, Loss #2 March 2013, Scar tissue discovered, RPL testing,
    IVF #3, BFP #3, Loss #3 (twins) September 2013
    Hostile ute, moving onto Gestational Carrier!

    GC/FET #1 of 1 5AA blast and 1 compacted blast, February 2014, BFP #4 on 3/1/2014!
    6w u/s 1 bean with h/b of 145 bpm, 8w u/s 187 bpm
    EDD 11/7/14. Please, please, please stick little one!

    Praying unceasingly for a miracle. ALL welcome!

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  • I transferred one with my first cycle and then two with my FET. If things go well and we have enough, we'll likely transfer two again this time.

    My thinking was that originally I wanted to avoid the possible complications from being pregnant with twins more than I wanted to avoid a failed cycle. But after a failed cycle, my odds at getting PG lowered even further.

    I wouldn't go above two embryos unless this goes on for a couple more years (oh, man, I hope that isn't the case) and my age starts to become a serious issue.

    GL with whatever you choose.

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  • I mentioned this in my ET post, but DH and I had said the whole time we would do whatever the RE recommended.  Initially, we were told that if we made it to a 5dt with an excellent blast, the recommendation would be to transfer one.  However, yesterday with my legs in the stirrups and spread eagle, the RE says "We are transferring two blasts today.  Okay?"  We were speechless.  RE left to wash his hands.  After sensing the shock, when he came back he asked my age and told us that we could elect to transfer only one.  However, his recommendation was to transfer both blasts.  RE looked at me to make the call.  I looked over at my husband and he blurted out "TWO!!"   So, two we did.

     

    This was a fresh cycle and now we have two on ice.  My clinic freezes in pairs, so any future FET would have two transferred (assuming both survive the thaw).

     

    I think it is a very personal decision.  Yesterday, we both just knew that two was the right decision.  GL!




    image image

    Me: 28; DH: 35 
    1/2008 -- Started TTC
    3/2009 - FD discovered at 17 weeks1/2011 - Lap and HSG reveal Stage IV Endo and both tubes blocked. 
    4/2012 - Consult with RE for IVF#1 - Labs and SA are normal - Repeat HSG - SURPRISE! Both tubes are open.
    May, June, August 2012 - IUI#1-3 - Letrozole + Bravelle + Ovidrel trigger = BFN
    9/2012 - Lap#2 to remove endo and Hysteroscopy 
    IVF#1 (Long Lupron) - 12/6 ER - 20R 11F * 12/11 ET - Transferred 2 excellent blasts * 3 Frosties * 
    Beta #1 79.7 * Beta #2 240 * EDD - 8.29.13 * It's a GIRL!

    BabyFruit Ticker

    When Not IF Blog

    Everyone welcome!
  • We aren't at the point to make this decision, but something we've talked about.  DH is set on 2, I'm not.  I'm just hoping we will be able to make that decision when the time comes. :)

    **SIGGY WARNING**

    TTC since Nov 2010 | Me: 29, DH: 31 
    DX - Severe DOR, Stage II Endo
    6 rounds medicated TI, 3 failed IUIs, 2 failed IVFs
    After nearly 4 years of trying, our 1st BFP on IVF #3 (5R, 3M, 3F, 3 day 5 blasts frozen) 
    FET - Beta #1 - 116, Beta #2 - 266!! 1st U/S on 10/6 - HB 121 and measuring perfectly! EDD 5/30/15

    Everyone Welcome
    Baseball, Beagles, Beer and Babies Blog

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  • We'll likely transfer 2 during our eventual FET as well. We look at it as two babies vs. no babies....we'll take two babies.

    Me- 32, DH- 32- TTC for 4 Years
    IUIs 1-6 BFN
    IVF #1= BFP- M/C
    FET- Beta#1: 69, #2: 482, #3: 1088, #4: 28,318, Ultrasound- 1 beautiful heartbeat
    It's a boy!

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  • While I'd like to transfer 2 each time, my RE only wants me to transfer one due to my uterine shape and clotting disorder. Only exception was IVF#2 , we transferred 2 but only because they both were the best we had but were both very poor quality. Provided all is well this time around, we're back to only 1.
    Me: 33, Endocrine issues & FVL       DH: 32, Nothing 
    NTNP 2009-2012         TTC since 2012:
    • Clomid, 2 IUI cycles, and 5 IVF cycles = BFN
    • FET #1   August 2013 = BFP!     EDD 5/11/14
    • Jack dx at 19w1d with Dandy Walker on 12/16/13
    • Severe Pre-e /HELLP set in Jack born sleeping at 20w1d on 12/23/13
    • FET #2 --July 2014  BFP!  ---  EDD  4/5/15

    Jack has handpicked his sibling up there :)

    My blog about IF and loss ... Kate's IF Blog

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  • As I am still studying, we had originally decided to do single ETs. I also did a literature search on PubMed and found that most studies show a similar take-home baby rate for single and double transfers. The rationale is that doing single ETs will require more time to get a BFP compared to doing double ETs, but as multiple pregnancies carry a higher risk for complications than singleton pregnancies, the results will even out at the end.

    So, this was theory... In real life, I've been so heartbroken after a mc and two failed single ETs, that my faith in science is completely shaken and I'm considering transferring 2 embryos if the next sFET also fails (we still have 3 frozen embies). After waiting for so long, I just want to be pregnant and I don't care with how many.

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  • I always thought I'd do two because I'd love to have twins (though given my track record it now looks like it would be near-miraculous if I even end up with one).  But honestly now that I've been on these boards for more than a year, especially lurking on the pregnancy boards, I have seen *so many* twin (and triplet) pregnancies end in late losses and stillbirths that I am frankly terrified to put myself in that situation.  (And it doesn't help that a few days ago I found out that a step-cousin lost twins at 6 months -- they simply died in utero with no warning.)  I know bad things can happen with singleton pregnancies, too, but it always seems to be the twin pregnancies that end in losses ~20 weeks.  Plus twins are much more likely to end up with disorders like cerebral palsy, or learning disorders, etc. that come from arriving much too early.  So I don't know.  With my own crappy eggs I might put back 2 or more but if I had actually decent embryos I'd be seriously tempted to do an SET.
  • We just had a conversation with my RE about a FET yesterday after finding an empty sac on the ultrasound screen.  She has always strongly recommended SETs and that is what we did the first time.  When I asked her about timing for the FET she said she recommended two periods before we "put in another one." So it sounds like she still recommends one (for women under 35 anyway -- I am 34). I did get pregnant with one, it just didn't stick. And maybe if I'd done two and they both implanted, I'd still be pregnant now. But I really don't want multiples, and since my frosties are all good quality and I have enough (5) to try a few FETs, I'm going to do another SET. If that one fails, I may get desperate and do 2 on the 3rd try, but that's a discussion we haven't had yet.

    I should say that although I don't want twins if I can help it, my concern is actually triplets. I have a close friend who transferred 2 embryos and ended up with triplets, one of whom she lost.  They were all in the NICU and she is lucky to have two healthy children, but I don't want to go through that.

    Married my wife 8/2007 ~ TTC #1 since 7/2011
    9 IUIs = 9 BFNs
    IVF October 2012: 22 eggs retrieved, 17 fertilized, 5 frozen
    ET #1: 1 blast = BFP; Blighted ovum discovered at 7w5d; D&E
    FET #1: 1 blast = BFP; Missed m/c discovered at 9w5d; D&E
    Karyotyping: normal ~ RPL Testing: normal ~ Hysteroscopy: normal
    FET #2: 1 blast transferred 10/25; BFP 10/31!
    EDD 7/13/14 ~ Induced at 37w4d due to pre-eclampsia ~ Born on 6/28/14
    *Everyone welcome*

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  • Thanks for your opinions ladies you all make great points. This is such a hard decision and DH and I went over a lot last night we looked at the pros and cons and we have some data charts comparing the  risks of carrying multiples compared to single pregnancy and while I'm nervous about those risks we are leaning toward putting back 2. We are also looking into the risks of using high doses of hormones and the effects it can cause down the line on me. I guess time will tell and my mind may change.






          


     TTC since 9/10 consult 1/12 All testing came back fine Diagnosed with Unexplained infertility -3 medicated IUI's All BFN IVF - ER 11/14 24R, 15M, 13F ET 11/19, BETA 11/28 BFFN --Next step FET in Jan ET scheduled for 1/24. Beta #1 350 Beta #2 735. U/S Hell. miscarriage D&C at 9weeks. FET #2 ET 5/28 cancelled FET# 2.5 6/26 ET Beta 7/5 302 7/7 Beta #2 632 Everyone welcome



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  • I am in the same decision boat as you.  Our last two FETs were single transfers - the first was a chemical pregnancy, the second was a miscarriage.  My doctor suggested next time we transfer 2.  There are a lot of reasons why I would prefer a single baby over twins, but after all the pain and heartbreak I've been through, the thought of twins (vs. no baby) isn't freaking me out...as much.  We still haven't finalized our decision (will need to in January).  It's so hard...

    My TTC Journey:
    Dx: Hypothalamic amenorrhea / mild PCOS (Pretty much a hormone/ovulatory disorder)
    Progesterone to induce period w/ the goal of Clomid - never got period (September 2011). Referred to RE.
    Femera - never responded to the meds (December 2011)
    Clomid with TI - BFN (February 2012)
    Injectables (Menopur) - hyperstimulated/canceled (March 2012)
    Injectables #2 (Menopur) with TI- BFN (May 2012)
    IVF - OHSS (transfer canceled), but 11 frozen! (June 1012)
    FET - 1 transferred on 8/09/12. Beta#1 (11dp5dt): 350.3; Beta#2: 365; Beta#3: 157. Biochemical pregnancy.
    FET # 2 - 1 transferred on 11/01/12. Beta#1 (11dp5dt): 337; Beta#2: 769. BFP!!! 1st ultrasound 11/28/12 showed heartbeat, but measuring 5 days behind. 2nd ultrasound 12/05/12 - miscarriage.
    FET # 3 - 1 transferred on 1/24/13. Beta#1 (11dp5dt): BFN.
    FET # 4 - 2 transferred on 3/21/13.  Bet #1 (11dp5dt): 660; Beta#2: 1,300.  Miscarried at home @ 6 weeks.

    FET # 5 - 2 transferred on 7/12/13.  Beta #1 (10dp6dt): BFN.
    Attempted an IUI in late August 2013, but didn't respond well.
    IVF #2 with PGS - Stims started 10/28 with retrieval on 11/11.  Of 14 mature eggs, 10 fertilized, 4 made it to Day 5 & 1 made it to Day 6. We did PGS on the Day 5 embryos, and 3 of 4 were normal. Had ET on 11/17. Beta #1 (8dp6dt): 203. Beta #2 (10dp6dt): 618. We since had two ultrasounds & on 12/19, our RE released us to the OB.  On 1/02/14, we had our first ultrasound with the OB where we heard the heartbeat.  We are so thankful for the blessing & crossing every finger & toe for a healthy & successful pregnancy.

    photo JuneBugs_IFbump.jpgimageimage

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  • We are planning on putting 2 back (standard practice for our RE for the most part). We aren't exactly hoping for twins. Hoping for 1 healthy happy baby, but we have agreed that we would rather have 2 than zero.
    Married 8/14/10 * TTC since Aug 2010 * Met with RE in Feb 2012 * DH: low motility, low sperm count, elevated FSH * Me: Stage 4 Endometriosis * Laparotomy to remove endo in May 2012 * June 2012 - DH on Rx to hopefully increase count/quality * Re-tested sperm 10/22/12, count/quality have both dropped * IVF #1 w/ICSI * Transferred 2 beautiful embryos on 2/18/13 * Beta #1 3/1/13 - 636!!! Beta #2 3/3/13 - 1796!!! First ultrasound scheduled for 3/18/13 Image and video hosting by TinyPic birthday2012_small Anniversary
  • My RE said that it is up to us but he strongly suggests only one.  So one it is.  I was bummed because I have always wanted twins.  But I will do what the dr says because he knows more than I do :)
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  • We have decided to transfer 2 for our IVF cycle (which will be our first). Our RE said it was totally up to us. We had a consult / interview with an OB that I will hopefully one day use. We discussed risks of multiples and possible negative outcomes. I'm not going to lie - some of them are scary. But we all decided together (me, Dh, RE, and OB) that we're comfortable transferring 2. We only have one shot at IVF. Hopefully we will have some embies for FET if IVF fails but we're still transferring 2. After I deliver I'll be having a hysterectomy so I won't get another chance at this.
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