Infertility

Crazy change of direction

Ok... So after our last failed ivf, we had our wtf meeting with our RE. We laid out plans for more tests, mainly for me since we didn't see my bad egg quality coming. Our original diagnosis was Azoospermia, during this process my husband has been on clomid and they were able o retrieve sperm through a biopsy.

something in the back of my mind kept saying we should do another semen analysis after being on the clomid, the RE said it didn't make much sense because he had 3  with no sperm. But I said let's do it anyway, and of course this time we had 17 million swimmers. Talk about shock.

 So now we have to go back and figure out what now? Still trying to figure out why my eggs were bad quality when all tests were normal.  

 I'm now on dhea and coQ10. I guess we will still have to do ivf? 

Re: Crazy change of direction

  • Like you, I was shocked after my first IVF cycle with bad egg quality.  I'm only 32 for goodness sakes!  I am not sure what the sperm count cut off is for IUI vs IVF.  Can I ask what dosages of dhea and coQ10 you are on and how long you will take them before attempting a second cycle?
    11/02/10- DS Born
    6/2011- DH started chemo for testicular cancer
    9/2011- Remission!!!!
    6/2012- IUI #1 natural with HCG shot- banked sperm (BFN)
    7/2012- IUI #2 natural with HCG shot- banked sperm (BFN)
    -changed RE-
    11/13/12- IVF #1 Bravella 225/Menopur 150/Ganarelix, triggered with Lupron. 11/27- 8R/2M + 2 mature next day/ 4 fertilized/ 2 grade III with 20% fragmentation transferred back on day 3. No frosties. BFN. Boo :(.
    Plan: New semen analysis in January and #2 IVF hopefully with fresh sample in March.
  • OMG that's so great about the sperm.......  Never thought I'd say that to anyone :)   YAY!!!
     36 DH 33 TTC for over 3 years
    First mini-IVF Sept 2011... Only 1 egg! ... BFN
    Switching RE
    IVF#2 May 2012 9 eggs and only 2 sperm, WTH!
    BFN
    IVF #3 March 2013~Tesa with back-up Donor Sperm,Tesa, unsuccessful used DS~ Chemical :(   

    Switching RE's within practice

    2 frosties waiting for us, November 2013!!!!!   Transferred 2 "average" blasts 11/20/2013
    BFP!!!!!!!  Boy/Girl Twins!!!!!! Due 08/08/2014

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  • imagefiresiren:
    OMG that's so great about the sperm.......  Never thought I'd say that to anyone :)   YAY!!!

    I notice that I am saying alot of things that I never thought that I would say either!  But I am so happy for your husband's sperm! 

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  • That is good news about the sperm! DH had similar count and we did IUI. Maybe that would be an option now?

    I have low AMH and starting coQ10 and DHEA to help that. Did your RE say how long until they start causing an effect? Do you know if the effect is measurable (ie blood tests) or just through the IVf process? 

    Me:30 low AMH; DH:30 MFI (count, motility, morphology)
    2 rounds clomid 100 mg -BFN
    IUI#1- 25 mg clomid- July 2012= BFN!
    IUI #2 August = BFN!
    IUI #3 September = BFN!

    IVF #1 November - converted to IUI #4 due to poor response = BFN
    IVF #1.2 February- converted to IUI #5 due to poor response = BFN
    IVF #1.3 April- micro dose Lupron flare with HGH; 14R, 13M, 11F! Transfer of 1 day 5 blast on 4/30, 4 frosties. BFP! Beta #1 9dp5dt= 179; Beta #2 11dp5dt= 442; Beta #3 4106 Stick baby stick!!

    *trying to keep hope*




  • I took dhea coq10 this cycle. 25mg 3x a day of dhea 200 mg 3xa day of coq10.
    "Everything will be alright in the end. So if it's not alright, it is not yet the end."
    Me:29 DH:29  TTC since 1/11 Dx: unexplained IF/early DOR/immune issues 
    Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN
    8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F. 
    ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN
    IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
    ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
    3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.  
    DX: High NK cells, cytokines, DHEAs& PAI1;  hypothyroid, +APA, restricted bloodflow
    7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
    (plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim)
    ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
    ET 5dt 7/24 2 fully expanded blasts.  SURPRISE 3 FROSTIES!!!
    Beta #1 8/2 335!!!! Beta #2 829!!!  1st u/s 8/14 showed TWINS!!!!!
    11/11: TEAM PURPLE!!!!!
    3/21/14-L&W born at 37w via csection

    Here Comes the Sun Blog
    PAIF/SAIF welcome!
  • I take coenzyme Q10.  I tried DHEA, and I don't know if it was related but that cycle my FSH jumped several points.  So I quit the DHEA, even though I know some people suggest it for women with elevated FSH.  
    TTC #1 12/2009
    BFP #1 1/2010, M/C 6 weeks
    BFP #2 6/2010, DD lost to
    congenital heart diseasewe are heartbroken.

    TTC #2 4/2011, diagnosed MTHFR, FVL
    Four natural cycles BFN; Clomid IUI BFN; Follistim IUI BFN;
    1/2012 IVF #1 BFN
    4/2012 FET BFP #3
    5/2012 7w1d u/s: anembryonic demise; M/C @ 8w.
    6/2012 found Stage II/III endo on laparoscopy, removed w/ laser.
    8/2012 IVF #2 epic fail: no viable embryos.

    Vacation, break, second opinions, on to new RE.
    1/2013 Surprise chemical pregnancy BFP #4 (break cycle), IVF #3 postponed.
    2/2013 TI w/ hormonal support, prednisone, aspirin, Lovenox, acupuncture gave us a miracle BFP #5!
    Heartbeat on U/S at 6w1d!
    Baby,please stay!!
    Our miracle baby boy arrived 10/2013!  We are so in love!!

    10/2014 Surprise BFP #6
    Our second daughter arrived in May 2015!  We are so grateful!  

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  • 75 mg of dhea, 600mg of coQ10. I have no idea how long results take or how they can be measured
  • I take 25mg DHEA 3x a day, 400 mg CoQ10 2x a day, 500 mg inositol 2x a day. My RE said 90 days to show an effect. 
    Me: 33, Hypothalamic Amenorrhea, DOR (AMH .35), DH: 38, Borderline low morph
    5/09- Off BCP, 5/09-9/09- No period, 9/09-9/10- Lots of Tests & accupuncture
    10/10 and 11/10- 2 rounds of Menopur + TI= BFNS
    12/10-IUI #1 Menopur = BFN
    1/11- IUI #2 Menopur = BFP, 2/11 missed mc at 9 weeks, D&C
    5/11- Operative Hysteroscopy to remove uterine septum
    6/11- IUI #3 Menopur = BFP, 8/11 missed mc at 11 weeks, D&C
    1/12- Lap and Operative Hysteroscopy to remove uterine septum (again) & scar tissue
    2/12- Stint Removal, 3/12 repeat SHG and HSG- showed scar tissue blocking right tube
    4/12- Operative hysteroscopy (again), RE said he can now see right tube (yay!)
    5/12- Stint removal, 6/12 repeat SHG and HSG-both tubes are open!
    8/12- IUI #4 Bravelle = BFN
    9/12-IUI #5 Bravelle = BFN
    1/13- IVF #1, micro-flare protocol, 7R, 6F, 5dt of 2 AA embryos, 1 to freeze = BFP
    Beta #1: 176, Beta #2: 422, EDD 10/8/13- it's TWINS!
    *PAIF/SAIF always welcome*
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  • imagejadwedd:

    imagefiresiren:
    OMG that's so great about the sperm.......  Never thought I'd say that to anyone :)   YAY!!!

    I notice that I am saying alot of things that I never thought that I would say either!  But I am so happy for your husband's sperm! 

    No advice about the egg quality but totally agree with this!! Glad this is going your waY at least, GL!!

    TTC since June 2011
    DX: DH (30) severe MFI, severely low count & low motility
    Me (32): all clear
    Appt with Urologist 5/21/12: exam, ultrasound, bloodwork all normal.
    Testicular Biopsy with TESE on 6/8/12. good sperm found! (left side only) froze sperm, failed thaw test :(
    Orientation for IVF/ICSI on 6/13/12. Waiting for the green light following biopsy results...results show adequate sperm production both sides.
    2nd SA 6/18/12: sample is "adequate for ICSI"
    Plan: IVF/ICSI July 2012!
    ER: 7/26/12. 15 eggs retrieved, all mature.
    TESE/TESA/aspiration from epididymis, no motile sperm found :(
    froze all eggs, the saga of praying for good sperm continues.
    8/3/12: 2nd opinion from MFI uro on biopsy slides. Suspects "partial late maturation arrest."
    Plan: more SAs, third biopsy/TESE with frozen back-up either from DH or DS.
    SA 8/17/12: Zero sperm
    SA 8/23/12: Zero sperm
    9/26/12: SPERM FOUND! 15 eggs thawed, 12 survived and were ICSI'd, only 3 fertilized normally. Refrozen as embies and will thaw in Nov. Please survive and grow!
    All 3 survived the thaw on 11/15/12!
    FET 11/17/12: transferred 2, one 4B, one 4C. Beta 11/30:BFFN
    moving on to DS
    DIUI#1 2/18/13,50mg Clomid cd 3-7, Ovidrel trigger, Beta 3/4/13: BFN.
    DIUI#2 3/19/13, 50 mg Clomid cd 3-7, Ovidrel trigger, Beta #1 (14dpiui) 4/2/13: BFP!!!! 150. Beta #2 4/4/13: 420 Beta #3 4/8/13: 2691. Beta #4 4/15/13: 15,086
    1st u/s 4/8/13 shows one gestational sac
    2nd u/s 4/15/13 shows yolk sac, fetal pole and early heartbeat
    3rd u/s 4/25/13: measuring right on track. Heart rate 148 bpm
    A/S 7/22/13: IT'S A BOY!!
    PAIF/SAIF Always Welcome
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