Infertility

Immune testing, killer cells, antiphospholipid antibodies testing

Anyone done this or talked with their doctor about it?  I have an RE in the family who recommended this now that I'm going through my second m/c, but my RE doesn't really believe it in. My RE said he'd still let me have the testing done since it can't hurt anything. just curious if anyone has had any experience with this.

Me: 35, DH: 34, Started TTC #1 since November '11
Several Clomid/Femara rounds, then fresh IVF September '12
Fresh IVF #1: chemical pregnancy, FET #1: ectopic, methotrexate
FET #2 resulted in our amazing baby boy Levi, born on 11/3/13 at 8 lbs, 5 oz. He is our everything!
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Re: Immune testing, killer cells, antiphospholipid antibodies testing

  • There is a lady from another group that I'm in who have tested positive for Natural Killer cells and antiphospholipid antibodies. They added baby asprin pre transfer and Lovenox or dexamethasone after they got their BFP. 

    If you want more info, PM me. I can give you a link to her blog. She has several posts about her diagnosis and experience.

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  • I am so sorry for your loss.


    I had autoimmune and thrombophilia panels done and those tests were part of the workup... Everything was normal in my case but I think it is well worth doing the testing.  Have you had karyotyping done?  That would be something you should also consider (for both you and DH).


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    TTC #1

    Me 42, DH 47

    Dx = AMA/DOR, MFI

    IVF/ICSI #1 = BFN

    IVF/ICSI #2 = BFP; early loss

    IVF/ICSI #3 (DE) = BFP; early loss

    FET = BFN

    IVF/ICSI #4 (DE w/ CCS) = BFP

    Beta #1 @ 10dp6dt = 265; Beta #2 @ 14dp6dt = 1251. 

    1st U/S @ 6w2d showed one perfect little heartbeat! 

    2nd U/S @ 7w2d. HB 132 & everything measuring on track.

    Our beautiful little girl arrived January 2015!


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  • thanks guys.  i'd appreciate the blog reference.  we are also doing the karyotyping on both my husband and myself.

    Me: 35, DH: 34, Started TTC #1 since November '11
    Several Clomid/Femara rounds, then fresh IVF September '12
    Fresh IVF #1: chemical pregnancy, FET #1: ectopic, methotrexate
    FET #2 resulted in our amazing baby boy Levi, born on 11/3/13 at 8 lbs, 5 oz. He is our everything!
    AlternaTickers - Cool, free Web tickers
    Image and video hosting by TinyPic  image   image
  • I had all that stuff done. It came up positive for natural killer cell activity, so I was tested to see if intralipid or IVIG were better for treating that. Both came up as suppressing equally well, so I was on intralipid for all of my Clomid cycles, my one IUI and an IVF cycle. BFNs all around. They switched it up to prednisone for my second IVF, this time an FET, and that was also a BFN. I'm starting to develop my own opinions about whether, even if there is an immune factor to infertility, there is a good treatment available yet. But those are just my uneducated opinions and they're only based on my one case study. Ultimately, it's up to you, your partner and your doctor to decide what's best for you. Good luck whatever you choose!
  • imagebluek210:
    thanks guys.  i'd appreciate the blog reference.  we are also doing the karyotyping on both my husband and myself.

    I PM'ed you! 

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  • imagebluek210:
    thanks guys.  i'd appreciate the blog reference.  we are also doing the karyotyping on both my husband and myself.

    bump burp

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  • If you're serious about RI workups I'd skip the RE and go directly to an RI. Their testing is much more comprehensive and treatment move acute. We had basic immune/RPL done with an RE and nothing was red flagged, but out RI did extensive testing and found issues; IMHO the treatment was much more focused and complete than what the RE was suggesting. However it's not easy or cheap and some of the treatments are extremely controversial. See the FAQ for more info, but this group is very informative.

    https://health.groups.yahoo.com/group/immunologysupport/messages 

    +++
  • I agree with various points by PP.  We did immune dysfunction testing with a RI specialist.  Most RE's do not subscribe to some of the theories.  However, be careful what you wish for, or next thing you know, some over zealous RE / RI will be telling you you can never carry a pregnancy with your DH and you need a surrogate or sperm donor!  I think somewhere in between disbelief and extremism would be great.  

    I think karyotyping is a good start for recurrent loss work up, also coagulation work up. Then you can get into the various autoimmune conditions, including thyroid.  Then natural killer cells, HLA typing and so on.  

    I agree with PP that there may not be a really effective treatment for these issues yet.  Not to mention, it may not actually be THE issue that is causing you problems.  Still, I think it is probably worth doing.  

    TTC #1 12/2009
    BFP #1 1/2010, M/C 6 weeks
    BFP #2 6/2010, DD lost to
    congenital heart diseasewe are heartbroken.

    TTC #2 4/2011, diagnosed MTHFR, FVL
    Four natural cycles BFN; Clomid IUI BFN; Follistim IUI BFN;
    1/2012 IVF #1 BFN
    4/2012 FET BFP #3
    5/2012 7w1d u/s: anembryonic demise; M/C @ 8w.
    6/2012 found Stage II/III endo on laparoscopy, removed w/ laser.
    8/2012 IVF #2 epic fail: no viable embryos.

    Vacation, break, second opinions, on to new RE.
    1/2013 Surprise chemical pregnancy BFP #4 (break cycle), IVF #3 postponed.
    2/2013 TI w/ hormonal support, prednisone, aspirin, Lovenox, acupuncture gave us a miracle BFP #5!
    Heartbeat on U/S at 6w1d!
    Baby,please stay!!
    Our miracle baby boy arrived 10/2013!  We are so in love!!

    10/2014 Surprise BFP #6
    Our second daughter arrived in May 2015!  We are so grateful!  

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