Infertility

Let's talk side effects!

So I started my (generic) Lupron (leuprolide acetate) on Saturday.  Injection was a piece of cake.  I have had two doses so far.  I am experiencing a metallic taste in my mouth.  Anyone else?

 

Also, when did you begin noticing the headache or hot flashes associated with this medication?  Any other side effects I should look forward to?  Thanks girls! 




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Me: 28; DH: 35 
1/2008 -- Started TTC
3/2009 - FD discovered at 17 weeks1/2011 - Lap and HSG reveal Stage IV Endo and both tubes blocked. 
4/2012 - Consult with RE for IVF#1 - Labs and SA are normal - Repeat HSG - SURPRISE! Both tubes are open.
May, June, August 2012 - IUI#1-3 - Letrozole + Bravelle + Ovidrel trigger = BFN
9/2012 - Lap#2 to remove endo and Hysteroscopy 
IVF#1 (Long Lupron) - 12/6 ER - 20R 11F * 12/11 ET - Transferred 2 excellent blasts * 3 Frosties * 
Beta #1 79.7 * Beta #2 240 * EDD - 8.29.13 * It's a GIRL!

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When Not IF Blog

Everyone welcome!

Re: Let's talk side effects!

  • I didn't have any side effects from the Lupron.
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  • The only side effect I noticed from the Lupron was a headache and it started the second day and didn't go away for 16 days. I hope the metallic taste is the worst you experience!

    [spoiler] My Blog: Grow Baby Grow

    BFP #1: 12/2009 m/c 1/2010 BFP #2: 6/2010 m/c 8/2010

    BFP #3: 10/2011 ectopic 11/2011 (right tube removed, learned left tube was probably nonfunctional due to scar tissue from infection after m/c)

    3 failed IUIs, IVF #1: 18R, 12M, 10F, 3 poor quality 5d embryos transferred= BFP #4!!!!!

    Betas: 9dp5dt: 64 ~14dp5dt: 91 (expecting miscarriage, doubling time of 236 hours) ~16dp5dt: 200~18dp5dt: 500

    First Ultrasound at 6w2d revealed two sacs, only one with a heartbeat

    LK arrived after 42 weeks on August 14, 2013! Beautiful, healthy, and happy!

    TTC#2: IVF booked for April 2015

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    Betas: 10dpo: 10, 14dpo: 77, 17dpo: 270

    First Ultrasound at 5w1d showed a miracle UTE baby! And right ovary ovulation to left fallopian tube.

    JD arrived at 38 weeks on October 20, 2015.

    TTC #3: Since October 2017. BFP #6 July 2, 2018 EDD: March 16, 2019 [/spoiler]


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  • I was on MDL...microdose Lupron...so I'm not sure if that had anything to do with it but I only hot flashed while taking the injection. Same thing with Menopur, when I would give myself the injections I'd have to take my sweater off and put the fan on , LOL

    For me, most side effects didn't hit until the progesterone, now thats a doozy, LOL

     

    Good luck :)

    Me: 33, Endocrine issues & FVL       DH: 32, Nothing 
    NTNP 2009-2012         TTC since 2012:
    • Clomid, 2 IUI cycles, and 5 IVF cycles = BFN
    • FET #1   August 2013 = BFP!     EDD 5/11/14
    • Jack dx at 19w1d with Dandy Walker on 12/16/13
    • Severe Pre-e /HELLP set in Jack born sleeping at 20w1d on 12/23/13
    • FET #2 --July 2014  BFP!  ---  EDD  4/5/15

    Jack has handpicked his sibling up there :)

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  • I've had the metallic taste in my mouth and horrible headaches since starting Lupron on Nov 2nd.  The last few days I've noticed that my hair is starting to thin out (more in the brush and when I shower) which is a fairly rare side effect. 
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    Me 33 DH 36 Together 10 years, Married 5 years

    TTC #1 since 8/2007 with MFI
    November 2012 - IVF w/ ICSI #1; 11/28/12 - ER 12 eggs! 11 fertilized! 12/3/12 - ET - transferred 1 AA Blastocyst
    Charlotte Hannah -born 8/13/13.
  • It made me itchy, but my RE and nurse said that they have never seen that before. I was also "Lupron crazy" - very emotional and short. Itching started right away - Lupron crazy didn't start until 5-6 days in.

    Hoping that you don't experience either of these :) 

    Dx PCOS 2006 - on Metformin
    Dx Hypothyroid 2009 - on Synthroid
    TTC since 12/2009
    DH - Low Sperm Count

    IVF with ICSI Cycle #1 - October/November- 10/11 Begin Lupron, 10/20 Begin 300iu Gonal-F, Trigger 10/31, ER 11/2, 12 retrieved, 11 mature, 6 fertilized, ET 11/5 - 2 Grade 1 8 cells, 2 frozen blasts (5BA, 3BB), Beta #1 @ 8dp3dt: 7, Beta #2 @ 11dp3dt: 2 :(

    IVF with ICSI Cycle #2 - January - 12/30 Begin Lupron, 1/8 Begin 300iu Gonal-F, ER 1/20, 13 retrieved, 11 mature, 6 fertilized, ET 1/25 - 2 blasts (grades 4BA, 1)

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  • I got a dull, continuous headache after 3 days of Lupron - still have the headache a week later. I also have become a bit angry/ragey as well. I hope you have minimal side effects - I'm NOT a fan of the Lupron!
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  • I too have a constant headache.  Mostly dull but at times, can get to pounding.  Tylenol doesn't do jack.  I am hoping it goes away when I start the stims.  Anyone know if that is the case?

    <Image and video hosting by TinyPic
    Married June 2011 Dx: anovulatory due to prolactinoma (1.5cmx 1.5cm in 2006)
    April 2012: MRI- questionable cyst 8mg by 12mm in pituitary ; referred to RE by Ob-gyn after amenorrhea x 4+ months, provera ineffective, low estrogen level
    cycle 1: May 2012, clomid 50mg; cycle cancelled, thin lining, no response
    cycle 2: June 2012, femara 5mg; cycle cancelled, no response
    cycle 3: July 2012, femara 7.5mg; cycle cancelled (largest folli on Cd12 & cd 16: 11, lining 4)
    Repeat MRI July 25,2012- Cyst unchanged, likely old infarction.
    Aug. 8: met with RE, move to injectables if HSG and SA normal
    Aug. 23: HSG all clear; DH- perfect
    Switched to a new RE in early Sept. IVF here we come
    Genetic testing reveals: Fragile X- Intermediate risk/grey zone.
    IVF#1: ER 11/30: 14 retrieved, 10 mature, 7 fertilized. E2 prior to trigger 5200. Decision made to freeze 6 embryos and transfer later due to OHSS.
    IVF#1.2/FET #1: estrogen injects start 1/18, FET delayed to try to thicken lining. lining 5.4mm. FET- 2/18- transferred one 3AA expanded blast. BFP 5dp5dt. Beta #1- 2/27 9dp5dt- 102.27 beta #2 3/1: 147 :(, beta #3 3/4: 268 told to stop meds and let nature take its course. requested 4th beta (3/6); Beta hell for 2 months.

    FET # 2: endometrial scratch 5/6, added estrace vaginally and ASA to delestrogen and PIO. June 10- transferred one 4AA hatched embryo, BFP 4dp6dt, Beta 1 (9dp6dt) 187, Beta 2 (11dp6dt): 412; Beta 3 (15dp6dt ): 4452. U/S #1- one beautiful embryo with a heartbeat of 133 at 7 weeks.  8 weeks: heartbeat 156. EDD 2/26/2014: born 2-3-14 induced due to Pre-E and HELLP at 36w5d.

    12/1: met with RE to discuss trying for #2


  • Looking back, my Lupron headache began on the 2nd day but I didn't realize it was from the Lupron until overnight on the 3rd day when I had a horrific throbbing headache.  I took enough Tylenol to dull it and it went away after about a week when my estrogen started to rise.

    That's the only side effect I experienced from the Lupron, fortunately.


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    TTC since 10/2010
    IUIs # 1-5 = BFFN
    IVF # 1(July 2012) = BFN
    IVF # 2 (November 2012) = BFP (MIssed MC D&C @ 8w3d on 1/10/13)
    IVF # 3 (June 2013) = BFN 
    IVF # 4 (September 2013) = BFP Fraternal twin boys! (Loss at 21w6d due to IC on 1/26/14...devastated.)
    3/21/14--TAC (transabdominal cerclage) w/Dr. Davis in NJ
    IVF # 5 (May 2014) = BFN
    FET (August 2014) = BFN

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  • I had the metallic taste too, but that was the only side effect i has on the Lupron.  It's normal and it will go away once your dose goes down.  At least thats when mine went away.

     

    Good Luck to you!!

  • I was super moody, but no physical side effects.  Well, sore spots on my belly from the injections and a few bruises.

    GL! 

    Natural m/c Oct. 2005

    Dx: balanced translocation and LPD

    TTC since Oct 2011

    BPF 02/19/12, EDD 10/31/12, natural m/c 02/28/12 (4w6d)

    IVF (BCPs starting 10/30/12, ER 11/18/12, 5dt of 1 beautiful, healthy embryo 11/23/12)
    BFP 12/02/12, u/s @ 6w,5d showed 2 HBs! Identical twins!!
    Bed rest from 21w-35w due to short cervix, hospital bed rest from 23w-32w due to PTL
    Our rainbows were born 07/19/13 (36w, 5d)

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  • I've had two dosages so far as well and have the same metallic, dry mouth.  I'm also really tired from it.  
    Brandon Le born 9/9/13 as a result of IVF#1


  • I had hot flashes from day 1 on lupron.. Never failed about 45 minutes after the shot I had a crazy hot flash where I stripped everything I had on... 5 minutes later I was fine and didn't happen again until after the next shot. Random.
  • The headaches and hot flashes lasted until they decreased my dose of Lupron. Out of all the meds Lupron was the one I had the most side effects. I'm hoping they aren't too bad for you.

    Me 38 MH 41 - TTC since June 2010 - dx with Severe MFI. Straight to IVF with ICSI. IVF #1 - ER 06/13/12 - 9 Eggs Retrieved - 4 ICSI'd - only 2 fert. 06/15/12 - 2DT - 3 cell & 6 cell with fragmentation. Beta 06/29/12 - IVF #1 = BFN. 07/20/12 - WTF Appt -Told by our RE to quit IVF. Second Opinion from RE is good. IVF#2 - November 2012. Estradiol Pills Started 11/6. Stims start 11/16. ER 11/26 - 7 eggs retrieved - all mature. 4 fertilized with ICSI. ET 11/29 Transferred 3 embryos. Beta is 12/10. 1st Beta 81 2nd Beta 160 and 3rd beta 360!!! First U/S 12/21/12 - We saw one beautiful gest. sac. 2nd U/S is 01/04/2013 - H/B 183 02/05/13 - NT Scan - everything looks good and IT'S A BOY!  Aiden was born 08/20/2013.

    IVF #2 is in progress.  ER was 05/12/14 - 11 eggs retrieved, 8 fertilized with ICSI.  ET was 05/15/14 - we transferred 3 embryos as we did on the cycle my son was conceived.  We were able to freeze 3 embryos. Beta is scheduled for 05/26/14.  1st beta - 111.  2nd beta - 159 didn't double :( 3rd beta Friday 5/30) - not a lot of hope left. Beta # 3 is 247 - probably ectopic.  Beta # 4 is 813 - possibly vanishing multiple sydrome?  06/05/14 - 5w4days - first U/S - we see a gestational sac and yolk - still have hope!  06/17/14 - 7w1day - U/S and saw and heard the heartbeat - Finally!  06/27/14 - 8w4days - Baby and heartbeat look and sound great :)  EDD 02/01/14 and It's a boy!


     "Everything will be okay in the end. If it's not okay, it's not the end."


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