Experieced IVFers... — The Bump
Secondary IF

Experieced IVFers...

Did you do genetic testing? Had consultation this morning and he said it can damage the embryos and can lessen the chances of it working. Dh wanted to do it, but now can't decide. Have to give an answer next week.
TTC #3 (#1 for DH) since September 2011. DX: Unexplained infertility with possible cervical factor. May 2012 did clomid with IUI - BFN August 2012 IUI #2 w/ follistim/letrozole - BFN September 2012 IUI #3 w/ follistim/letrozole - BFN October 2012 IUI #4 w/ follistim/letrozole - BFN November/December 2012 IVF/ICSI #1 Retrieved 12 eggs, 8 fertilized. Transferred 1 beautiful embryo and 5 made it to freeze. Got my BFP! January 2013 u/s showed empty gestational sac. FET cycle April 2013.  Transferred 2 5 day embryos.  BFP!!!!!  2 heartbeats!!!!  EDD:  12/27/13

Re: Experieced IVFers...

  • I did not do genetic testing on my embryos, but have heard that it can decrease their viability in some cases.  Why did your RE bring it up?  Was it just a general, hey, here's a service we provide, or was there a reason related to your treatment/dx history that the RE felt it was worth considering?

    If you don't have any known risk factors to suggest using it, I probably wouldn't do it, but that's just me.

    10/10: Married; 5/11: Dx: Blocked Fallopian Tube; 7/11: D&C/Hysteroscopy to remove polyp
    IVF #1: 9/11: ER: 12R, 11M, 10F, No Frosties; 5dt: 2 blasts, 1 morula; DD born 6/3/12
    IVF #2: 11/12-12/12: ER: 20R, 20M, 16F, 4 Frosties; 5dt: 3 blasts, DS born 8/9/13
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  • My RE said a similar thing adding that the technology is not advanced enough in his opinion and it does damage the embryos, plus you need enough embryos to be able to do it and they have last to five days, so many ifs.  We asked about it because of our recent losses and the fact we are out OOP for our third IVF cycle, two fresh, and just want to do everything possible for a success.  We are doing ICSI (we have to) plus assisted hatching this time.  Good luck with your decision.   
    H: 34 dx Azoospermia due to CBAVD from CF  
    ME: 39 IS FINE!!!  DOR and poor AMH/FSH/LH
    IVF/ICSI/PESA #1 Beta 1 373 Beta 2 1783 BOY/GIRL TWINS!! Born April 2010!!
    Natural FET 5/26/12 2 blasts Beta 1 207 Beta 2 513 Beta 3 1377 U/S 6/28 Pregnancy not viable d & c scheduled :( 
    IVF/ICSI/PESA #2 ER 11/15/12 Nothing to transfer :( 
    IVF/ICSI #3 April 2013 MDLF 3dt of 3 embryos, chemical :(  
    IVF #4/ICSI/MESA/CCS/FET EPP April 2015
    ODWU CCRM with Dr. Sch COMPLETE!!!! Put on acai supplement they are studying for DOR and embryo quality.
    DAY 3 Labs Drawn 2/26 put on vitamin D and calcium supplements
    Regroup and Protocol Reveal 3/04 "Bazooka Protocol" EPP with MDLF "Protocol 6 with patches"
    ER/MESA 4/10 ER 9 eggs retrieved MESA success found live swimmers :)
    Fertilization Report 6 eggs mature and ICSI'd 4 eggs fertilized normally
    Day 6 Report to Blast for CCS 4/16: 2 DAY 5 BLASTS BIOPSIED FOR CCS a 4AB and a 3AB!!!!
    CCS Results BOTH BLASTS CCS NORMAL!!!!!!  call on 4/24
    Regroup call to discuss CCS results and FET call on 5/20
    FET prep: CD 1 6/08 CD 3 Start BCP 6/10, HSG 6/12 Lupron Start 10 iu 6/17 End BCP 6/21 CD 1 6/23!!!
    Start vivelle patches 6/25 change e/o/d reduce Lupron to 5iu 6/25 Blood Draw 7/01, 7/08, 7/15, 7/19
    Increase vivelle patches 7/03 2 change e/o/d and 7/05 change e/o/d 3 and 7/07 4 change e/o/d add vaginal estrace 2x a day
    Lining Check/Blood Draw 7/08 and 7/15 End Lupron 7/18  Start PIO 1ml daily 7/18  Blood  Draw 7/19
    Flight to clinic 7/22
    FET 2 CCS BLASTS :) :)  7/23 :) :) YES YES both thawed and both fully expanded :) :)
    7/26 :) :) 3dp5dt PM very very faint positive FRER
    7/27: 4dp5dt Neg Digi AM but very very faint positive FRER PM POSITIVE DIGI CLEARBLUE PREGNANT 1-2 :) :) 
    7/31:8dp5dt AM POSITIVE DIGI CLEARBLUE PREGNANT 2-3!!!! :) :) 
    Beta 1 8/01= 408!!!!!!!!!! at 9dp5dt FET
    Beta 2 8/03 = 1014!!!!!!!!!! at 11dp5dt FET
    8/05/2015 AM POSITIVE DIGI CLEARBLUE PREGNANT 3+!!!! :) :) 
    First Ultrasound: 8/20!!!!!! TWINS!!!!!!!!!!!!!!!!!  Genetics says BOTH BOYS!!!!!!!!!
    Second Ultrasound: 9/03!!!!!!!!!!










     










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  • image nawlinsgrl:

    I did not do genetic testing on my embryos, but have heard that it can decrease their viability in some cases.  Why did your RE bring it up?  Was it just a general, hey, here's a service we provide, or was there a reason related to your treatment/dx history that the RE felt it was worth considering?

    If you don't have any known risk factors to suggest using it, I probably wouldn't do it, but that's just me.

     

    I just asked for my own curiousity.  I have a newphew with Down Syndrome and my family thought if it was option that maybe we should do it.  However, I am pretty sure I'm going to pass.  There's no point if it could hurt the embryos.

    TTC #3 (#1 for DH) since September 2011. DX: Unexplained infertility with possible cervical factor. May 2012 did clomid with IUI - BFN August 2012 IUI #2 w/ follistim/letrozole - BFN September 2012 IUI #3 w/ follistim/letrozole - BFN October 2012 IUI #4 w/ follistim/letrozole - BFN November/December 2012 IVF/ICSI #1 Retrieved 12 eggs, 8 fertilized. Transferred 1 beautiful embryo and 5 made it to freeze. Got my BFP! January 2013 u/s showed empty gestational sac. FET cycle April 2013.  Transferred 2 5 day embryos.  BFP!!!!!  2 heartbeats!!!!  EDD:  12/27/13
  • I'm lurking over here and wanted to chime in. We have to do genetic testing, I have a balanced translocation 13:14 so I have a huge risk of having an embryo with monosomy 13 or 14 or trisomy 13 or 14. We're 37 so after 2m/cs we decided to stop trying naturally and do IVF w/ PGD. My RE does arrayCGH testing on day 5 blastocysts. They draw cells the embryo is over 100 at that point from what will be the placenta, not the fetus. Different than FISH or day 3acgh that take one out of 8 cells on day 3.
    We had an FET last Tuesday of two expanded blasts that tested normal they test all 46 chromosomes and I've had a hpt since 6dp5dt beta is tomorrow so please do your research into what kind of testing tm your lab does, it makes a difference. If T21 runs in your family, it might be worth the peace of mind, only you and your H can decide that.
    Btw, my testing was 2950 a cycle.
    Feel free to PM me if you have more questions... I hang out on the IF board!

    Sorry about formatting, I'm on my phone.
    TTC#1 
    BFP 2/14/11, missed m/c 9 weeks. d&e 3/24/11
    BFP 12/10/11 d&e at 13wk+4days 2/17/12
    Dx with Balanced Robertsonian Translocation (13;14) moving on to IVF w/ PGD
    IVF #1 (May 2012) 13R, 10F, 5 blasts, ONE NORMAL frozen no transfer
    IVF #2 (July 2012) 17R, 8F, 5  blasts, ONE NORMAL 6dt on 7/12/2012- c/p
    IVF #3 (Sept. 2012) 39R, 25F, 13 blasts,  3 NORMALS! Freeze-all due to high E2.
    FET #1 10/23- 2 expanded blasts, Beta #1 11/1- 113, Beta #2 11/4-351, Beta #3 11/7- 1213
    Hailey Michelle born July 12, 2013

    TTC #2 
    FET -1/14- c/p
    IVF #4 (Feb 2014)- 49R, 28F, 13 blasts, 7 NORMALS! eSET of a normal blast on 2/24/14, 6 frosties.
    Beta #1 3/4/14- 105. Beta #2 3/7/13- 397 EDD-11/11/14. 1st u/s 3/20- 6w2d lil' bean with 120hb. 7w0d- lil bean's hb was 144. Graduated from RE 3/25/14.
      Image and video hosting by TinyPic
  • I did it twice.  Second time had very confusing results, end up doing re-biopsy.  I am still not sure it is the right thing to do.  I think there is a significant chance of getting mis-information and being forced to make a decision based on it.  I don't think I am going to do genetics the next go round.  Will just wait for blast that looks good!

     

    TTC #1 12/2009
    BFP #1 1/2010, M/C 6 weeks
    BFP #2 6/2010, DD lost to congenital heart disease, we are heartbroken.

    TTC #2 4/2011, diagnosed MTHFR, FVL
    Four natural cycles BFN; Clomid IUI BFN; Follistim IUI BFN;
    1/2012 IVF #1 BFN
    4/2012 FET BFP #3
    5/2012 7w1d u/s: anembryonic demise; M/C @ 8w.
    6/2012 found Stage II/III endo on laparoscopy, removed w/ laser.
    8/2012 IVF #2 epic fail: no viable embryos.

    Vacation, break, second opinions, on to new RE.
    1/2013 Surprise chemical pregnancy BFP #4 (break cycle), IVF #3 postponed.
    2/2013 TI w/ hormonal support, prednisone, aspirin, Lovenox, acupuncture gave us a miracle BFP #5!
    Heartbeat on U/S at 6w1d! Baby,please stay!!
    Our miracle baby boy arrived 10/2013!  We are so in love!!

    10/2014 Surprise BFP #6
    Our second daughter arrived in May 2015!  We are so grateful!  

    Lilypie Angel and Memorial tickers


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  • image Ironmom2be:
    I'm lurking over here and wanted to chime in. We have to do genetic testing, I have a balanced translocation 13:14 so I have a huge risk of having an embryo with monosomy 13 or 14 or trisomy 13 or 14. We're 37 so after 2m/cs we decided to stop trying naturally and do IVF w/ PGD. My RE does arrayCGH testing on day 5 blastocysts. They draw cells the embryo is over 100 at that point from what will be the placenta, not the fetus. Different than FISH or day 3acgh that take one out of 8 cells on day 3. We had an FET last Tuesday of two expanded blasts that tested normal they test all 46 chromosomes and I've had a hpt since 6dp5dt beta is tomorrow so please do your research into what kind of testing tm your lab does, it makes a difference. If T21 runs in your family, it might be worth the peace of mind, only you and your H can decide that. Btw, my testing was 2950 a cycle. Feel free to PM me if you have more questions... I hang out on the IF board! Sorry about formatting, I'm on my phone.

     

    And in addition to my previous remark, I totally agree w/ this PP.  You have to know what you are doing and if you have a particular reason to do it.  Otherwise, I would say just wait to see what makes it to blast and decide how many you want to transfer.   

    TTC #1 12/2009
    BFP #1 1/2010, M/C 6 weeks
    BFP #2 6/2010, DD lost to congenital heart disease, we are heartbroken.

    TTC #2 4/2011, diagnosed MTHFR, FVL
    Four natural cycles BFN; Clomid IUI BFN; Follistim IUI BFN;
    1/2012 IVF #1 BFN
    4/2012 FET BFP #3
    5/2012 7w1d u/s: anembryonic demise; M/C @ 8w.
    6/2012 found Stage II/III endo on laparoscopy, removed w/ laser.
    8/2012 IVF #2 epic fail: no viable embryos.

    Vacation, break, second opinions, on to new RE.
    1/2013 Surprise chemical pregnancy BFP #4 (break cycle), IVF #3 postponed.
    2/2013 TI w/ hormonal support, prednisone, aspirin, Lovenox, acupuncture gave us a miracle BFP #5!
    Heartbeat on U/S at 6w1d! Baby,please stay!!
    Our miracle baby boy arrived 10/2013!  We are so in love!!

    10/2014 Surprise BFP #6
    Our second daughter arrived in May 2015!  We are so grateful!  

    Lilypie Angel and Memorial tickers


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  • I've had multiple losses but did not do pgd testing because of the extra cost involved. Good luck in your decision!
    After many years and tears our baby boy is finally here
    Born 11-6-10

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  • Thanks for everyone's input. I am still pretty uncertain. Dh was born with clubfoot and apparently that is related to something genetic having to do with chromosomes. He told me it could be associated with other factors. I had no idea that was his issue and have no knowledge on the subject. I thought he was concerned about Down Syndrome because of my nephew. He seems very uneasy about not testing, but I'd rather just not do it. We have a few days to decide! I really appreciate everyone's thoughts. :
    TTC #3 (#1 for DH) since September 2011. DX: Unexplained infertility with possible cervical factor. May 2012 did clomid with IUI - BFN August 2012 IUI #2 w/ follistim/letrozole - BFN September 2012 IUI #3 w/ follistim/letrozole - BFN October 2012 IUI #4 w/ follistim/letrozole - BFN November/December 2012 IVF/ICSI #1 Retrieved 12 eggs, 8 fertilized. Transferred 1 beautiful embryo and 5 made it to freeze. Got my BFP! January 2013 u/s showed empty gestational sac. FET cycle April 2013.  Transferred 2 5 day embryos.  BFP!!!!!  2 heartbeats!!!!  EDD:  12/27/13
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