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New diagnosis of MTHFR

monimu13monimu13 member
in Trouble TTC
So after my most recent m/c my RE decided to do a bunch of blood tests for recurrent miscarriages.  I am somewhat familiar with MTHFR just from my work (I'm a Neonatal NP), but realized I dont know as much as I would like.  My RE said that our next step is going to be high dose folic acid/b-vitamin supplements, Clomid, Trigger, and TI (DH wants to wait a little longer until we start IUI).  Anyone have any advice or experiences? TIA!
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 Anniversary
TTC since July 2011
BFP #1: 2/15/12-Ectopic/Mtx at 6 wks
BFP #2: 10/12/12-m/c at 5 wks. 
BFP #3: 8/27/13
Me: MTHFR, Low AMH (1.1), High NK cells and Antiphospholipid Antibodies.
DH:MFI-Low morph (1%), DNA fragmentation: Excellent!
5 rounds of clomid, 3 IUIs, and multiple non-medicated cycles- BFFN                                                      
IVF with ICSI in August 2013 brought us our babies.  ER-9R, 7M, 4F w/ICSI  ET of 2-Grade 2 blasts. 
+ HPT at 6dp5dt. #1 (8dp5dt)- 105    #2 (13dp5dt)- 510  #3 (15dp5dt)- 960  #4 (17dp5dt)- 1889
Dx shortened cervix, PTL, and preeclampsia during pregnancy.  Lots of medications and 13 weeks of bedrest, babies were born healthy at 34w4d!

imagehttp://oi44.tinypic.com/10dwifm.jpg
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Re: New diagnosis of MTHFR

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    kristykay123kristykay123 member
    I dont have any advice but want to say Hi, friend! ::waves:: I'm glad you have a plan! 
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    jschwind22jschwind22 member
    No advice Moni, but I'm glad you are getting the testing done!  I'm so sorry for your losses.  I hope that the testing all goes well!
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    alb245alb245 member

    Do you know which type of MTHFR you have?  I'm homozygous (so 2 copies) of C677t.  From everything I've read, that is the most severe of the MTHFR's.  Also, do did you get your fasting homocysteine levels checked?  I've read a lot that states if your fasting homocysteine levels are normal, even if you test positive for MTHFR, your risks are not as great, and you *may* not even need treatment, as opposed to if your levels are higher/abnormal.

    There seem to be two main issues with MTHFR (specifically with 2 copies of the c677t) from what I can tell: 1) Increased risk for blood clots (possibly causing early losses and even late losses due to clots in the uterus/placenta) and 2) decreased ability to convert folic acid into the usable form of methyfolate (causing neural tube defects, losses usually occur with anencephaly).

    The jury is kind of out on the whole blood clotting issue. The most recent statements I've read from ACOG (and someone else) don't think that lovenox is required during pregnancy unless you also test positive for another clotting disorder.  A lot of physicians will still prescribe lovenox in this situation (or allow you to take it if you feel strongly about this) because it won't really cause any harm either.  Most just recommend a daily baby aspirin and that's it.  And if you are heterozygous (one copy of the c677t and one of the A gene), they definitely don't recommend Lovenox during pregnancy (from what I've read).

    The jury is also out on whether to prescribe megadoses of folic acid/b-vitamins (like Folgard) or to prescribe something like Metanx (sp?) that already has the folic acid converted into the usable form of methylfolate.  I read somewhere (don't remember the article) that we only are able to convert/process 20-30% of the folic acid that we consume. So taking the megadose like Folgard allows you to convert the recommended 800 mcg. 

    Anyways, please feel free to PM me with any questions or anytime you want to chat. I've done a lot of reading and I'm always interested in learning more about it too.  Good luck!

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    alb245alb245 member
    I would also recommend starting the high dose folic acid asap. I was freaking out with my last PG because we didn't get the diagnosis of MTHFR until I was 5 weeks pregnant and I knew the neural tube was closing/had closed by then.  I started on Folgard at the same time.  Turns out, it didn't matter, but I read a lot of posts where women were on the high dose folic acid for >3 months before a treatment cycle.
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    TTC #1 since Feb 2011 Dx: MTHFR C677T Homozygous, Antiphospholipid Syndrome, LPD
    BFP #1: 8/4/11 c/p 4w5d
    BFP #2: 9/4/11 c/p 5w0d
    BFP #3: 1/16/12 c/p 4w0d
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    monimu13monimu13 member

    imagekristykay123:
    I dont have any advice but want to say Hi, friend! ::waves:: I'm glad you have a plan! 

    Hi there lady! 

    CafeMom Tickers
     Anniversary
    TTC since July 2011
    BFP #1: 2/15/12-Ectopic/Mtx at 6 wks
    BFP #2: 10/12/12-m/c at 5 wks. 
    BFP #3: 8/27/13
    Me: MTHFR, Low AMH (1.1), High NK cells and Antiphospholipid Antibodies.
    DH:MFI-Low morph (1%), DNA fragmentation: Excellent!
    5 rounds of clomid, 3 IUIs, and multiple non-medicated cycles- BFFN                                                      
    IVF with ICSI in August 2013 brought us our babies.  ER-9R, 7M, 4F w/ICSI  ET of 2-Grade 2 blasts. 
    + HPT at 6dp5dt. #1 (8dp5dt)- 105    #2 (13dp5dt)- 510  #3 (15dp5dt)- 960  #4 (17dp5dt)- 1889
    Dx shortened cervix, PTL, and preeclampsia during pregnancy.  Lots of medications and 13 weeks of bedrest, babies were born healthy at 34w4d!

    imagehttp://oi44.tinypic.com/10dwifm.jpg
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    monimu13monimu13 member

    imagealb245:
    I would also recommend starting the high dose folic acid asap. I was freaking out with my last PG because we didn't get the diagnosis of MTHFR until I was 5 weeks pregnant and I knew the neural tube was closing/had closed by then.  I started on Folgard at the same time.  Turns out, it didn't matter, but I read a lot of posts where women were on the high dose folic acid for >3 months before a treatment cycle.

    Thanks for all the info!  She didnt say specifically which 2 copies (I plan on getting the print out when I go in for an appt).  She told me that I wouldnt need any anticoagulant therapy at this point.  I'm starting the Folgard tonight.  I'm sure I'll have more questions, thanks so much! 

    ETA: I didnt get a homocysteine level drawn, I'll bring that up with my next phone call to them.   

    CafeMom Tickers
     Anniversary
    TTC since July 2011
    BFP #1: 2/15/12-Ectopic/Mtx at 6 wks
    BFP #2: 10/12/12-m/c at 5 wks. 
    BFP #3: 8/27/13
    Me: MTHFR, Low AMH (1.1), High NK cells and Antiphospholipid Antibodies.
    DH:MFI-Low morph (1%), DNA fragmentation: Excellent!
    5 rounds of clomid, 3 IUIs, and multiple non-medicated cycles- BFFN                                                      
    IVF with ICSI in August 2013 brought us our babies.  ER-9R, 7M, 4F w/ICSI  ET of 2-Grade 2 blasts. 
    + HPT at 6dp5dt. #1 (8dp5dt)- 105    #2 (13dp5dt)- 510  #3 (15dp5dt)- 960  #4 (17dp5dt)- 1889
    Dx shortened cervix, PTL, and preeclampsia during pregnancy.  Lots of medications and 13 weeks of bedrest, babies were born healthy at 34w4d!

    imagehttp://oi44.tinypic.com/10dwifm.jpg
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    monimu13monimu13 member
    imagejschwind22:
    No advice Moni, but I'm glad you are getting the testing done!  I'm so sorry for your losses.  I hope that the testing all goes well!
    thanks :)
    CafeMom Tickers
     Anniversary
    TTC since July 2011
    BFP #1: 2/15/12-Ectopic/Mtx at 6 wks
    BFP #2: 10/12/12-m/c at 5 wks. 
    BFP #3: 8/27/13
    Me: MTHFR, Low AMH (1.1), High NK cells and Antiphospholipid Antibodies.
    DH:MFI-Low morph (1%), DNA fragmentation: Excellent!
    5 rounds of clomid, 3 IUIs, and multiple non-medicated cycles- BFFN                                                      
    IVF with ICSI in August 2013 brought us our babies.  ER-9R, 7M, 4F w/ICSI  ET of 2-Grade 2 blasts. 
    + HPT at 6dp5dt. #1 (8dp5dt)- 105    #2 (13dp5dt)- 510  #3 (15dp5dt)- 960  #4 (17dp5dt)- 1889
    Dx shortened cervix, PTL, and preeclampsia during pregnancy.  Lots of medications and 13 weeks of bedrest, babies were born healthy at 34w4d!

    imagehttp://oi44.tinypic.com/10dwifm.jpg
    Report Reply
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    rrdiva1rrdiva1 member
    No advice, but wanted to wave hey LAdy!!!! <3 Glad you have a plan~~~~~ <3
    Married BF 6/29/2002/
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    BellaLuxBellaLux member
    No experience, but just wanted to wish you good luck moving forward!

    ~TTC#1 Since July 2011~ 
    Dx: Fibroids & Tubal Infertility
                                                        9/12 -IVF#1 =BFN; 5/14 -IVF#2=BFP:-) EDD 2.19.2015                                                

    S/PAIF Welcome 





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    monimu13monimu13 member
    Thanks ladies!!
    CafeMom Tickers
     Anniversary
    TTC since July 2011
    BFP #1: 2/15/12-Ectopic/Mtx at 6 wks
    BFP #2: 10/12/12-m/c at 5 wks. 
    BFP #3: 8/27/13
    Me: MTHFR, Low AMH (1.1), High NK cells and Antiphospholipid Antibodies.
    DH:MFI-Low morph (1%), DNA fragmentation: Excellent!
    5 rounds of clomid, 3 IUIs, and multiple non-medicated cycles- BFFN                                                      
    IVF with ICSI in August 2013 brought us our babies.  ER-9R, 7M, 4F w/ICSI  ET of 2-Grade 2 blasts. 
    + HPT at 6dp5dt. #1 (8dp5dt)- 105    #2 (13dp5dt)- 510  #3 (15dp5dt)- 960  #4 (17dp5dt)- 1889
    Dx shortened cervix, PTL, and preeclampsia during pregnancy.  Lots of medications and 13 weeks of bedrest, babies were born healthy at 34w4d!

    imagehttp://oi44.tinypic.com/10dwifm.jpg
    Report Reply
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