Question about Letrozole — The Bump
Trouble TTC

Question about Letrozole

I haven't been very active on TB in a long time.  A lot has happened.  I was DX with endo and had a lap in Jan of this year.  My husband and I had been TTC for a year at that point.  Since then we have just been temping and doing ovualtion predictors.  I had my first consult with my RE in July.  My prenatal blood work came back normal but my husbands sperm analaysis had a normal count but borderline morphology.  I just had my CD3 bloodwork done, along with a follie count.  Count was good.  He said he could count at least 16 which he said was great but he put me on Letrozole for CD4 -CD8 with a planned IUI. 

My question is: Will the Letrozole make me ovulate on a certain day?  I usually ovulate on CD 17 but in the IUI instructions it mentioned that if I have not had a positive OPK by CD 14 that I should go in for an ultrasound. 

image TTC SINCE Feb 2011 DX with ENDO Jan 2012 removal via lap Tubes checked and clear Jan 2012 RE consult July 2012 Sperm Analysis showed borderline morphology IUI after a round of Letrozole 5mg Aug 2012= BFN 2nd round of Letrozole 7.5mr

Re: Question about Letrozole

  • You should be monitored when on any medicine, just not if you haven't had an OPK by a certain day.  Plus most RE's tell you not to use OPK's because they are a waste of money because you should be monitored throughout your cycle (b/w and u/s) and that they are not always accurate due to medicines.
    P/SAIF Welcome


    TTC Since 7/2010


    TTC with charting, OPK's, etc since 8/2010


    RE Appointment 9/9/11 = Unexplained IF. All tests for DH and I normal


    2 Clomid + TI cycles = BFN


    1 Clomid + IUI = BFN


    1 Clomid + Injects + IUI = BFN


    IVF #1 take 1 begins 8/6/12.


    Surgery to remove uterine polyp 8/28/12 All clear!


    Break due to Gallbladder Surgery 9/13/12.


    IVF #1 Take 2 begins 9/7/12, Lupron begins 9/23/12
    Stims begin 10/1/12 (150 Units of Bravelle and 75 Units of Menopur)


    ER 10/15 12 eggs retreived, 12 mature and 8 fertilized on their own!


    ET 10/20/12 Transferred 2 embies, 1 good and 1 fair extended blasts. 3 frosties waiting for us.


    Beta #1 10/31 = 756 (11dp5dt)


    Beta #2 11/2 = 1,310 (13dp5dt)


    Beta #3 11/5 = 4,158 (16dp5dt)


    First u/s 11/12 @ 6w = TWINS!! Both with heartbeats.


    Next u/s 11/21 @ 7w3d = Both with heartbeats of 162 and 165.


    Graduation Day 11/30 = Both babies looking perfect with heartbeats of 182 each.










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  • Letrozole (aka Femara) will not necessarily make you ovulate on a certain day and may change your ovulation from your natural cycle.  In most cases if it did move it would bring it closer to day 14, but this is by no means guaranteed.  I go to a large RE's office with a good reputation and they always tell me to do OPKs.  My doctor also automatically does an u/s on CD 12ish (10 days after starting oral medications), but if I got a positive OPK before that u/s or in between that u/s and the next scheduled appointment then I would return for IUI. 

    TTC with PCOS since July 2011.
    IVF Oct/Nov 2012
    Beta #1 = 77, Beta #2 = 190, Beta #3 = 1044
    Cautiously optimistic.
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  • My RE did the same thing as yours- I did Femera (letrozole) CD 2-6, and used OPKs.  If I didn't have a natural LH surge before CD 14, I would go in for an ultrasound and blood work.  If I did surge before then, they would do an ultrasound before the IUI to be sure of how many follicles and that everything was looking good.  If it was, then they did the IUI.

    To answer your question, before Femera I typically Oed CD 19-20.  With Femera, I Oed CD 14, CD 18, and CD 13.  So, for me, it did move up my O day.

      image

    TTC starting November 2010  HSG clear, DH SA #1- Slightly low count & motility SA#2-normal
    Lap&Dye/Hysterscopy Feb 2012: Endo stage 2
    April - June 2012: Femera 5 mg & 3 IUIs = All BFN    July/August 2012: IVF #1 = C/P
    September/October 2012: IVF #2 BFP! Beta 1= 223 Beta 2 = 480 Beta 3 = 11,440
    My beautiful daughter was born June 21, 2013
    TTC #2 naturally, no luck
    IVF #3 April 2015: BFN
    IVF #4 July 2015: BFP! Beta 1 9dp5dt = 409, Beta 2 13dp5dt = 1743


  • Thanks Ladies.  I appreciate the information.
    image TTC SINCE Feb 2011 DX with ENDO Jan 2012 removal via lap Tubes checked and clear Jan 2012 RE consult July 2012 Sperm Analysis showed borderline morphology IUI after a round of Letrozole 5mg Aug 2012= BFN 2nd round of Letrozole 7.5mr
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