Infertility

DE cycle off to a bad start :(

I am so frustrated.  My ED has done 3 previous cycles, all spectacular.  She got 19 eggs on the first one, 22 eggs on the next two cycles.  The last two cycles both resulted in twins and a ton of frozen embryos on all 3 cycles.

So, we paid top dollar for her assuming that we would have similar results.  Today I got a call from the RE that after a week of stims, she is only showing about 6-10 follies. I am so bummed, I don't even know what to think.  I swear I have the worst luck in the world.  He changed her meds and is hoping for some more growth but we are looking at way less than she has done before. 

The RE thinks that as long as we have 6 we will trigger her in the next couple of days, but if we are unhappy with this we can cancel and try again.  Which is of course more waiting and more $ (we are OOP for all donor costs).  I honestly didn't think we would have any decisions like this to make using an ED. I thought it would be a no-brainer and that we would have more embryos than we knew what to do with.  Has anyone had to make a decision to cancel with an ED?  Help!

4/08 BFP resulted in m/c
8/08 BFP resulted in m/c
3/09 Polyp removed and dx MTHFR (both copies)
6 Clomid cycles, all BFN
5/09 IUI#1 with Clomid=BFN
6/09 IUI#2 with Clomid=BFN
8/09 IUI#3 with Clomid=BFN
IVF#1 = BFN
IVF#2 = BFN
IVF#3 ET 2 Grade A blasts 11/16/11
Beta #1: 485
Beta #2: 2,495
Lilypie First Birthday tickersimage
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Re: DE cycle off to a bad start :(

  • I am so sorry, I don't know what else to say except that it really does only take one egg, so 6-10 follies is still decent stats, but I agree it's not as good as her previous results and I would have thought too that it would have been a no brainer...again I am sorry you are going through this.
    Married to the Mr. 8/6/2008- Together 10+ TTC #2 R/X unexplained infertility/premature ovarian failure/diminished ovarian reserve
    FSH (16) AMH (.61) AFC (9)
    Male factor: low sperm count/ low motility
    IVF #1 11/10 brought us DS Stimming for IVF #2 begin 11/5/11 AFC (7) =( Protocol: Lurpon flare (2 days) + Lupron 10ml/Menopur 4 vials (AM) Lupron 10ml/300IU Gonal-F PM (converted to IUI) failed IVF 2.1 1/12 BFP!
  • I have no experience with this but I am so so sorry that your cycle is progressing like this. Hugs and much luck with your decision.

     

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  • Sending her growing vibes! I know it is not the #s you are expecting but that is still pretty good if you can get closer to 10. Hang in there! I am sorry this has been so stressful for you 
    Pregnancy Ticker
  • I am sorry.  That really stinks.  Do you save money if you cancel before ER/ET?  If there were only 6 follicles I might cancel if it would save you a significant amount of money and try again with a fresh start.
  • imageMrkyrain:
    I am sorry.  That really stinks.  Do you save money if you cancel before ER/ET?  If there were only 6 follicles I might cancel if it would save you a significant amount of money and try again with a fresh start.

    I would only be out the cost of all her meds which we would need to re-order.  I agree with you, I just don't know what the cutoff should be at this point.  How many is enough?  The RE says 6 but that seems so awful to me based on this girl's previous cycles especially.

    4/08 BFP resulted in m/c
    8/08 BFP resulted in m/c
    3/09 Polyp removed and dx MTHFR (both copies)
    6 Clomid cycles, all BFN
    5/09 IUI#1 with Clomid=BFN
    6/09 IUI#2 with Clomid=BFN
    8/09 IUI#3 with Clomid=BFN
    IVF#1 = BFN
    IVF#2 = BFN
    IVF#3 ET 2 Grade A blasts 11/16/11
    Beta #1: 485
    Beta #2: 2,495
    Lilypie First Birthday tickersimage
    imageimageimage
  • I am sorry to hear things are not progressing as you would like.  That is a hard decision to make...keep us posted.

    Hugs!!

    I am AMA and all tests on H came back normal
    3 failed IVF with OE and 2 failed frozen DE cycles
    Last fresh hail mary DE cycle starting Feb 2013
    PAIF/SAIF always welcome
  • I'm so sorry things aren't going as well as you had hoped.  I hope that she'll have a better response with different meds and that the ER will go better than planned.  Best of luck!
    Mom to Eliott Alexander, born sleeping at 37 weeks on 8/13/10. Most of us only dream of angels - I held one in my arms.
    BFP #2 - EDD 2/26/12 M/C 6/28/11 @ 5w2d
    BFP #3 - EDD 4/7/12 M/C 8/2/11 @ 4w2d
    Too beautiful for this earth
    BFP #4 - EDD 12/09/12, Lucille arrived 11/26/12
  • I just wanted to say I am sorry and I hope your RE is able to turn it around in time.
    ~TTC since July 2010~
    CD3 Bloodwork:Normal 
    HSG-Clear 
    SA:Low Morph 
    IVF with ICSI #1: ER 12/16 (4 ER/3 Mature/0 Fertilized) 
    IVF with ICSI #2: ER 5/17 (4 ER/4 Mature/3 Fertilized)/ET 5/20 (2 embryos transferred)-BFN 
    IVF with PICSI #3: ER 9/8 (11 ER/8 Mature/7 Fertilized)/ET 9/13 (2 AA blastocysts transferred) 
    Beta#1, 9/26/12: 719 Beta#2, 9/28/12: 1,436 Beta#3, 10/1/12: 3,446
    1st u/s on 10/10/12: It's Twins! We found out on 12/16/12 that we were having two BOYS!
    C & D were born on 5/16/13 at 10:46 am and 10:47 am


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  • I'm sorry to hear this -- how disappointing given her previous results.  I don't have any advice for you, but wanted to send you hugs and tell you good luck with your decision.
    Married 8/2008. IVF with PGD March 2013.
    3/22 ER: 25R, 20M, 15F. 9 genetically normal, and 3 survived to Day 5
    3/27 ET: transferred 1 embryo, beta 9dp5dt=163, 12dp5dt=639
    4/25 1st ultrasound at 7 weeks = identical twins with heartbeats?!!!
    PPROM at 31w, delivery at 32 weeks of two beautiful girls
    image
  • Oh hun! I'm so sorry things aren't going well. I'm sending her lots of growing vibes and I hope that at the next follie check there will be a ton more!


    BFP#1 {Cashew} - 9.19.09 EDD 5.26.10
    The day you first lay in my arms, you made my life complete.
    Aurora Rose born sleeping at 35w on 4-21-10
    BFP#2 {Almond} - 2.1.11 EDD 10.12.11 C/P 2.11.11

  • I'm sorry that it's not what you've anticipated. My doctor said the average is 8, which always makes me so surprised when people get 15+. 

    Do you know how long it was between her last cycles and yours? I know people tend to respond less to the meds after a while, so having a 6 month break can improve things, which is probably not what you want to hear.  

    Try to follow your heart and your doctor's advice. I hope things improve over the coming days and that you don't have to worry. 

    (Live in Europe) TTC since 1/2010
  • No advice...  But sending you lots of luck and (Hugs)
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  • I'm sorry this is happening. That's a very hard decision, and I don't have any experience. How will you feel if you proceed and it doesn't work? And, where would you stand financially having paid top-dollar for this donor if it doesn't work? I would plan on worst-case scenario and try to make my decision based on that. Good luck.
    TTC #1 since June 2010
    Me: 36, DH: 42
    Dx: DOR and MFI

    DH: low count + very low motility; hormones all normal; Sperm DNA Frag. test = poor to fair; male karyotyping normal
    Me: FSH 13.4 + AMH 0.26 + hypothyroidism; Scratch the hypothyrodism (?); Blood clotting and immune panel all negative; endometrial biopsy normal

    IVF #1 (MDLF - Jul/Aug 2011): BFN (9R, 5M, 3F with ICSI, 3dt of 1 10-cell grade 2, no frosties)
    IVF #2 (EP-antagonist - Sep/Oct 2011): BFN (6R, 4M, 3F w/ ICSI, 3dt of 1 6-cell, 1 7-cell, grade 4s, no frosties)
    DE IVF #1 (shared cycle - June 2012): c/p (6R, 6F w/ICSI, 3dt 1 8-cell grade A- and 1 7-cell grade A-; no frosties)
    DE IVF #2 (shared cycle with new donor - Nov/Dec/ 2012): - BFP!!!!! 12/14/12. U/S on 12/27 shows twins!!!!!

    SAIFW/PAIFW
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