1st Trimester

Anyone else on prometrium?

After my bleeding scare last week, the doctor put me on prometrium suppositories. They determined that my progesterone is lower than it should be even though they were able to find the baby and heartbeat at 5 weeks, 5 days. Anyway,  I was wondering if anyone else had side effects from it.  I 
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Re: Anyone else on prometrium?

  • I am.  Taking it vaginally will decrease side effects compared to an oral dosage because it bypasses metabolization in the liver.

    The first week, I had increased fatigue and would fall asleep within half an hour of taking it and sleep soundly.  After the first week though, no such luck.  I noticed that my boobs would get a bit more sore and if I was nauseated when I went to bed, that might get a little worse.

    Other than that, no effects, just a bit messy.


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  • I was on oral prometrium during my 2ww and am now on suppositories.  For me, it has increased my fatigue, tender breasts, and is quite messy.  I noticed in my last pregnancy it made me bloated pretty early on. 
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  • Thanks ladies. I didn't take it the first time around, so this is all new to me. I have only been taking it since Friday.  I was worried I wasn't putting them in correctly since it was messy in the morning, but I guess that is a common issue. I was exhausted before taking it, so I'm not sure if that is any worse. I definitely feel more bloated than last time...but that could also be because it is number two. 
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  • This is my first pregnancy so I can't say if it's making and symptoms worse, but I know I can't wait to be off of the suppositories.  They're messy and an overall pia.  I'll be on them for at least another two weeks. Maybe another six.

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  • I'm on it until week 10. I take mine vaginally. It's my first pregnancy so I'm not sure what would be different. Sore BB's and tired more. Mine are neon yellow. Sometimes there is a build up and you get some pretty good size globs. Sorry if TMI.
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