Infertility

F/U To KTHappy's Post Re: IVF/MFI/MC

Hi KTHappy :)

I was just reading the post from a couple days ago about IVF/MFI/M/C and whether m/c rates are higher for girls w/ MFI who do ICSI.  I was curious about it so started doing some research.  Thought I'd pass along this article.

 https://www.ncbi.nlm.nih.gov/pubmed/15608032

I didn't find much else in the way of research articles, although I did read that SOME types of MFI may carry an increased risk of chromosomal issues - I think mostly low count can have a risk of Y-chromosome microdeletion. 

TTC in 2008. Stage II/III endo, Hashimotos hypothyroid, low morph (3%).
2 cycles Clomid/Ovidrel/TI/Crinone=BFN.
IUI #1 - 4 Follistim/Ovidrel/IUI/Crinone = BFN.
IVF #1 - Antagonist w/ ICSI 4/10. 17 retrieved, 5DT of 2, BFN :(
IVF #2 - Long Lupron w/ ICSI 6/10. 15 retrieved, 3DT of 2, BFFN!!
Lap 7/21/10
IVF #3 - Clomid/Antagonist w/ ICSI 10/10. 14 retreived, 3DT of 3, BFP 10/20 but m/c. No HB 11/15/10 - D&C 11/17/10.
FET - 2 blasts, 1 survived the thaw. Transfer 2/19. Beta #1 3/1 375, Beta #2 3/3 885, Beta #3 3/8 4261, Beta #4 3/11 9005. U/S 3/8 1 sac 1 yolk, U/S 3/16 1 heartbeat 114bpm!

 

James born Oct. 24th 2011 via c-section at 38 weeks!

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Surprise BFP - Jack born April 28, 2013 via VBAC after PTL at 33 1/2 weeks!

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Re: F/U To KTHappy's Post Re: IVF/MFI/MC

  • Thanks Patchen!  I actually found this study when I started poking around too. ;)  I just can't get over how many ladies we have on this board whose only/primary dx is MFI, that have gotten pg w/IVF w/ICSI, only to lose the baby.  My DH has awesome counts, but low morph and borderline motility (on the last SA). 

    I guess I'm just trying to figure out if there is some sort of method to this madness...  All of our RE's and my DH's uro have all said that his low morph does not help explain/cause our IF.  Angry  So the testing/cycing continues...

    TTK 9/06 / TTC 10/08 / Twins 12/11 / Life Blog
    5 REs + 3 surgical hysteroscopies for septum/lap + 3 failed IUIs
    IVF w/ICSI/AH & acu = BFP!, unexplained spontaneous m/c @ 8w2d (our little girl),
    FET w/acu = BFP!, B/G twins!, lost MP @19w, dx w/funneling cervix @20w,
    twins nearly lost to IC @21w, saved by rescue cerclage, 17P & 16w of bedrest
    Our twins born @36w4d via CS when A came foot first

    Thankful for every day

    Baby Birthday Ticker Ticker

  • imagekthappy76:

    Thanks Patchen!  I actually found this study when I started poking around too. ;)  I just can't get over how many ladies we have on this board whose only/primary dx is MFI, that have gotten pg w/IVF w/ICSI, only to lose the baby.  My DH has awesome counts, but low morph and borderline motility (on the last SA). 

    I guess I'm just trying to figure out if there is some sort of method to this madness...  All of our RE's and my DH's uro have all said that his low morph does not help explain/cause our IF.  Angry  So the testing/cycing continues...

    It is all very confusing (and frustrating!). We have very similar dx and my REs have said the same - that DH's low morph may contribute but isn't all the cause of our IF. They all thought IUIs should work for us :(

    TTC in 2008. Stage II/III endo, Hashimotos hypothyroid, low morph (3%).
    2 cycles Clomid/Ovidrel/TI/Crinone=BFN.
    IUI #1 - 4 Follistim/Ovidrel/IUI/Crinone = BFN.
    IVF #1 - Antagonist w/ ICSI 4/10. 17 retrieved, 5DT of 2, BFN :(
    IVF #2 - Long Lupron w/ ICSI 6/10. 15 retrieved, 3DT of 2, BFFN!!
    Lap 7/21/10
    IVF #3 - Clomid/Antagonist w/ ICSI 10/10. 14 retreived, 3DT of 3, BFP 10/20 but m/c. No HB 11/15/10 - D&C 11/17/10.
    FET - 2 blasts, 1 survived the thaw. Transfer 2/19. Beta #1 3/1 375, Beta #2 3/3 885, Beta #3 3/8 4261, Beta #4 3/11 9005. U/S 3/8 1 sac 1 yolk, U/S 3/16 1 heartbeat 114bpm!

     

    James born Oct. 24th 2011 via c-section at 38 weeks!

    Baby Birthday Ticker Ticker

    Surprise BFP - Jack born April 28, 2013 via VBAC after PTL at 33 1/2 weeks!

    Baby Birthday Ticker Ticker
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