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MTHFR- Hetero A1298C
So I requested a copy of my records and got them today since I will be getting a second opinion at Cornell on Tuesday.
While going through my records, I found that I have a gene mutation for MTHFR A1298C heterogeneous.
My first thought was um why did my doctor not tell me about this.
I am going to ask him about it next time I see him but I am already taking extra folgard.
How often does the treatment include aspirin and or lovenox/heparin?
Feb 2010 - IVF #1 BFP, miscarriage with D&C
April 2010 - IVF #2 BFN
June 2010 - IVF #3 BFP, Baby girl born March 2011
Oct 2011 - Natural BFP, D&C Dec
Jan 2012 - back to RE
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Re: MTHFR- Hetero A1298C
I have the homozygous mutation of the C677t, so I'm not too familiar with your mutation. My doctor had my fasting homocysteine levels tested, started me on daily 81mg aspirin (baby aspirin), and 4mg of folic acid/day + PNV. Although my homocysteine levels were normal (which is good), I will still use Lovenox upon a BFP since I've had 3 m/cs.
More & more information is finally coming out about the MTHFR mutation, but the medical community continues to change their minds about the true seriousness of it related to pregnancy & miscarriage, as well as treatment protocols. I would definitely bring it up to your doctor though. IMO, if any results other than normal are returned on a patient, the patient should be notified.
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I also just learned that I have MTHFR, but I am compound heterozygous with the one you have and also C677T. My doctor called me with the results but explained nothing and didn't even tell me which type I had. He prescribed Folgard, told me I didn't need baby aspirin, and told me to google MTHFR. Yes, google it.
We have an appointment next week with a genetic counselor at St. Luke's/Roosevelt. I feel like the genetic specialists will be able to answer all of our questions and give us a peace of mind that the RE can't or won't.
I found this explanation really helpful: https://nobabymama.blogspot.com/2009/02/mthfr-tutorial.html
It sounds like the kind of MTHFR you have is pretty common and there's a lot of debate about whether it even effects pregnancy, but I still can't understand you not being told and also what is the harm in taking the mega-dose of folic acid if there is a problem? I had to push my doctor for the thrombophilia panel in the first place and I just don't understand holding back and taking a less-is-more approach when we are spending thousands of dollars and injecting crazy drugs every day for weeks. We're way past less-is-more!
Good luck!