MTHFR and Frustrated — The Bump
Trouble TTC

MTHFR and Frustrated

Hi All,

 I'm finally so frustrated that I've decided to stop lurking around the boards and actually throw this out there to see if anyone else is in a similar boat.

We've been wanting kids forever but getting through college, stable careers, etc have delayed it a little bit.  Then we finally started trying in April 2008.  We're not patient people so we got OPK's and at home tests for semen (before we knew that's a joke) to try to get some answers since insurance doesn't test til 12 months.  My husbands results were initially lower than normal and went to a specialist who said he's normal on all levels.  My specialist determined I have MTHFR, a blood clotting disorder.  Now I feel blessed that we didn't get pregnant because those usually end in miscarriages up to 8 months along.

 Now we're on our 5th IUI, done clomid, have had over 12 internal ultrasounds, and numerous injections of hormones.  Even though we've got another week left in the 2WW, I'm already getting PMSy and don't feel any different.  Same as the last 19 cycles.  The physical pain I can deal with, i.e. daily self injections including ice packs to prevent hematomas, multiple prescriptions, and various other pokes and prods.  But the mental and emotional drain is going to get me in the end.  Anyone else out there with MTHFR or words of advice?  Is there more testing we should be doing?  When do you move on to IVF when all signs are pointing that these IUIs should be working?

Thanks

Re: MTHFR and Frustrated

  • Hey- I have MTHFR also. How it's handled depends a lot on whether you are homo or hetero, and whether you have another blood clotting issue too. Do you know what you are? I'm assuming your injections are for the IUIs. When you get a BFP again, your doctor might recommend Lovenox or baby asprin, depending on how serious your issue is. My MFM told me this week that MTHFR is not the big deal everyone thought it was 5 years ago, and that it by itself does not usually cause pregnancy complications. I don't believe it's accurate to say that MTHFR usually leads to miscarriage up to 8 months. Maybe your RE can recommend an MFM to help you with that. GL.
    BFP #1- 1/16/09- Baby Ava stillborn at 32 weeks, possible cord accident, 7/30/09
    BFP #2- 1/5/10- Baby Jack born at 37w2d, 6lbs 13 oz, 8/24/10
    BFP #3- 7/30/11- Baby Boy Due April 3, 2012
    Lilypie Angel and Memorial tickers Baby Birthday Ticker Ticker Pregnancy Ticker Image and video hosting by TinyPic
  • Thanks!  I can't remember if I'm homo or hetero, that was awhile ago and they threw so many terms at me at once.  Right now, no BFP to date.  I'm do a Lovenox injection each day.  I have PAO or POA1 as well.  I take a prescription strength prenatal w/extra folic acid in it.  I then take 3 more mg of folic acid but extra b vitamins and a baby aspirin, each day.  My body doens't absorb folic acid like it should. 

     Its just frustrating that I"m doing what I need to for MTHFR and that my ovulation is always 3-5 follicles and lining looks good and progesterone levels are good and the semen looks good but no baby.  Did you have to do any IUIs or IVF or anything?

  • If you have trouble metabolizing folate, you are probably homozygous.

    I have not yet had fertility issues, so no IUI or IVF for me. I got pregnant last time naturally so I have not investigated anything else yet.

    Sounds like your doctor is very aggressive with the Lovenox. That's a good sign! I hope all goes well.

    BFP #1- 1/16/09- Baby Ava stillborn at 32 weeks, possible cord accident, 7/30/09
    BFP #2- 1/5/10- Baby Jack born at 37w2d, 6lbs 13 oz, 8/24/10
    BFP #3- 7/30/11- Baby Boy Due April 3, 2012
    Lilypie Angel and Memorial tickers Baby Birthday Ticker Ticker Pregnancy Ticker Image and video hosting by TinyPic
  • image angiewolf03:

    Thanks!  I can't remember if I'm homo or hetero, that was awhile ago and they threw so many terms at me at once.  Right now, no BFP to date.  I'm do a Lovenox injection each day.  I have PAO or POA1 as well.  I take a prescription strength prenatal w/extra folic acid in it.  I then take 3 more mg of folic acid but extra b vitamins and a baby aspirin, each day.  My body doens't absorb folic acid like it should. 

     Its just frustrating that I"m doing what I need to for MTHFR and that my ovulation is always 3-5 follicles and lining looks good and progesterone levels are good and the semen looks good but no baby.  Did you have to do any IUIs or IVF or anything?

    It sounds like you're doing everything you can for the MTHFR (I have a type as well). As for everything else - hang in there. Moving from IUI to IVF is a big decision that can only be made by you and your SO. We did it after 5 IUIs and 2 losses. It's SO hard when everything looks like it should be right on track to then end up with AF. Also, don't be afraid to get a second opinion. Does your RE have an idea why so many cycles ahve failed?  Does your RE have a gameplan for the future?

    Good luck with everything - I hope you get pg soon.

    Lilypie Third Birthday tickers
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