Questions about biopsy — The Bump
Infertility

Questions about biopsy

The urology specialist told my DH that everything looked normal in his bloodwork and other samples. He sent off one more vial of blood to get tested and has taken an additional sperm sample, even though the last two have shown a zero count. The important thing is that the doc has scheduled a biopsy for DH for the end of March (yay, more waiting), I assume to see if there are sperm in the testes. (I really wish I could be there at appointments to hear more directly from the doc!)

Has anyone's DH ever gotten a biopsy done? What is the process like? Should I expect DH to be sore afterward? How long did it take you to get your results? I know the biopsy will give us our closest chance for answers at this point, but I don't like that I have to wait another month. Meh.
Me: 35 DH: 28
TTC since June 2016

Azoospermia diagnosis (zero count) Dec 2016

AZFc chromosome microdeletion discovery March 2017
Unsuccessful TESE for DH in August 2017
October 2017 IVF with donor sperm
29R, 24M, 16F, 2d5, 4d6 (6 embryos total)
Only 3 could have PGS. 2/3 normal. 5 embies frozen
12/15/17 FET #1 (1 embryo)--CP
2/7/17 FET #2 (2 embryos)--BFN
Chronic endometritis diagnosis May 2018
ERA Sept 2018--borderline receptive--12 more hours of progesterone
Abnormal SIS Oct 2018
Repeat hysteroscopy Nov 1. Treated recurring endometritis.
FET #3--December 4
~*~*~Nevertheless, she persisted~*~*~

Re: Questions about biopsy

  • I don't know anything about the biopsy, but wanted to say, I've never seen a better use of "Nevertheless, she persisted" than in your siggy.  Good luck, @AlohaKumu
    ~Mom to an amazing Jan 2011 boy~
    ~EDD Nov 18, 2017 with my IUI success story~


    BabyFruit Ticker


  • Thanks, @pawcall! I thought it was pretty appropriate for many of our journeys! :)
    Me: 35 DH: 28
    TTC since June 2016

    Azoospermia diagnosis (zero count) Dec 2016

    AZFc chromosome microdeletion discovery March 2017
    Unsuccessful TESE for DH in August 2017
    October 2017 IVF with donor sperm
    29R, 24M, 16F, 2d5, 4d6 (6 embryos total)
    Only 3 could have PGS. 2/3 normal. 5 embies frozen
    12/15/17 FET #1 (1 embryo)--CP
    2/7/17 FET #2 (2 embryos)--BFN
    Chronic endometritis diagnosis May 2018
    ERA Sept 2018--borderline receptive--12 more hours of progesterone
    Abnormal SIS Oct 2018
    Repeat hysteroscopy Nov 1. Treated recurring endometritis.
    FET #3--December 4
    ~*~*~Nevertheless, she persisted~*~*~
    pawcallBusinessWife
  • My husband had a biopsy since he also had zero sperm but bloodwork looked normal. We knew it was most likely blocked vas deferens from a surgery he had as an infant. It won’t be pleasant for your husband since they will have to stick needles in his testicles but you should have results the same day if they are just looking for sperm. The procedure isn’t very long so that is good but hubby will be sore for a few days. Just tell him what our urologist told my husband and thats what he has to go through is much easier than what us ladies have to do during IVF and pregnancy. Haha! In my case they were able to find lots of good sperm to freeze which is great but they did warn us aspirated sperm doesn’t freeze as well as ejaculated sperm so now he might need to done all over again the day of my egg retrieval if it doesn’t thaw well. Just another thing to add to the stress of it all. GL to you and your husband!

    Me: 31 DH: 31 Married: 8/2007
    MFI - Due to blockage
    IVF#1 Feb/Mar 2017 - ER: 14 Eggs, 13 Mature, 7 Fertilized, 1 Blastocyst (PGS tested abnormal)
    IVF#2 May 2017 - ER: 16 Eggs, 14 Mature, 5 Fertilized, 1 Blastocyst (PGS tested abnormal)
    IVF#3 July/Aug 2017 - ER: 15 Eggs, 13 Mature, 12 Fertilized, 6 Blastocyst, 5 PSG normal (3 Girls, 2 Boys)
    FET# 1 September 29,2017 1st Beta - 236 2nd Beta - 806 3rd Beta - 2932
    Due Date - 6/17/18 Father's Day!
    BusinessWife
  • Thank you so much @HottLemonade2886. I figured it wouldn't be a very pleasant experience, so I'll be sure to be mindful of his soreness. I'm thrilled to know that we should have results quickly the day of the testing! That's also good to know that we may have to do another retrieval if we have to go to IVF route, as long as they find that he has sperm. I really appreciate all the information.
    Me: 35 DH: 28
    TTC since June 2016

    Azoospermia diagnosis (zero count) Dec 2016

    AZFc chromosome microdeletion discovery March 2017
    Unsuccessful TESE for DH in August 2017
    October 2017 IVF with donor sperm
    29R, 24M, 16F, 2d5, 4d6 (6 embryos total)
    Only 3 could have PGS. 2/3 normal. 5 embies frozen
    12/15/17 FET #1 (1 embryo)--CP
    2/7/17 FET #2 (2 embryos)--BFN
    Chronic endometritis diagnosis May 2018
    ERA Sept 2018--borderline receptive--12 more hours of progesterone
    Abnormal SIS Oct 2018
    Repeat hysteroscopy Nov 1. Treated recurring endometritis.
    FET #3--December 4
    ~*~*~Nevertheless, she persisted~*~*~
    BusinessWife
  • Yes if your only option is aspirated sperm there is a high chance that your only option is IVF with ICSI.
    Me: 31 DH: 31 Married: 8/2007
    MFI - Due to blockage
    IVF#1 Feb/Mar 2017 - ER: 14 Eggs, 13 Mature, 7 Fertilized, 1 Blastocyst (PGS tested abnormal)
    IVF#2 May 2017 - ER: 16 Eggs, 14 Mature, 5 Fertilized, 1 Blastocyst (PGS tested abnormal)
    IVF#3 July/Aug 2017 - ER: 15 Eggs, 13 Mature, 12 Fertilized, 6 Blastocyst, 5 PSG normal (3 Girls, 2 Boys)
    FET# 1 September 29,2017 1st Beta - 236 2nd Beta - 806 3rd Beta - 2932
    Due Date - 6/17/18 Father's Day!
    BusinessWife
  • Also very good to know. At least I'll be mentally prepared for that to be on the horizon, depending on our options. I wish you the best of luck on your IVF journey, @HottLemonade2886!
    Me: 35 DH: 28
    TTC since June 2016

    Azoospermia diagnosis (zero count) Dec 2016

    AZFc chromosome microdeletion discovery March 2017
    Unsuccessful TESE for DH in August 2017
    October 2017 IVF with donor sperm
    29R, 24M, 16F, 2d5, 4d6 (6 embryos total)
    Only 3 could have PGS. 2/3 normal. 5 embies frozen
    12/15/17 FET #1 (1 embryo)--CP
    2/7/17 FET #2 (2 embryos)--BFN
    Chronic endometritis diagnosis May 2018
    ERA Sept 2018--borderline receptive--12 more hours of progesterone
    Abnormal SIS Oct 2018
    Repeat hysteroscopy Nov 1. Treated recurring endometritis.
    FET #3--December 4
    ~*~*~Nevertheless, she persisted~*~*~
    BusinessWife
  • We didn't have to have this, but our good friends did at our same RE 8 years ago. The cutest thing they said was, they actually had to have their moms in on the process, because they both got conscious sedation the same day and neither could drive the other. So, right after the semen aspiration, they got a ride to the egg retrieval! Good news is, it worked with a fresh sample and fresh day 5 transfer!

    Married: October 2014

    Me: 35 DH: 39

    TTC since November 2014

    Diagnosis: Anovulation from PCOSish without syndrome, Male factors - low motility and morphology issues

    April-Sept. 2015 - Clomid and TI - BFN

    Dec. 2015- HSG - Clear tubes

    Jan., Feb., March 2016 - Letrozole 7.5mg and TI with HCG trigger= BFN

    April, May, June 2016 - Letrozole 7.5mg and IUI with HCG trigger= BFN

    September 2016 - IVF round #1;ER 9/26 with ICSI on 14 eggs - developed mild OHSS. 

    Sept 2016 - 12 non-PGS embryos frozen (5 5AAs)

    FET #1 Jan 16, 2017 - BFP!- MC at 6W5d

    FET #2 May 8, 2017 - BFP! EDD 1-24-2018

    BusinessWife
  • That is good news @JESSABER0414! Our moms are a couple thousand miles away from us, but I'm sure our friends would gladly give us a ride if they knew what was up :)
    Me: 35 DH: 28
    TTC since June 2016

    Azoospermia diagnosis (zero count) Dec 2016

    AZFc chromosome microdeletion discovery March 2017
    Unsuccessful TESE for DH in August 2017
    October 2017 IVF with donor sperm
    29R, 24M, 16F, 2d5, 4d6 (6 embryos total)
    Only 3 could have PGS. 2/3 normal. 5 embies frozen
    12/15/17 FET #1 (1 embryo)--CP
    2/7/17 FET #2 (2 embryos)--BFN
    Chronic endometritis diagnosis May 2018
    ERA Sept 2018--borderline receptive--12 more hours of progesterone
    Abnormal SIS Oct 2018
    Repeat hysteroscopy Nov 1. Treated recurring endometritis.
    FET #3--December 4
    ~*~*~Nevertheless, she persisted~*~*~
    BusinessWife
  • We haven't had the biopsy, but that is a huge step!  Very exciting!  What day is his procedure?

    I was talking with someone who said that her H got 6 vials!!!  And they just used one vial per ivf cycle, so they expect to have plenty for future cycles just from the one biopsy.  There are so many variables though, it really depends and every situation is different.  Fx it goes smoothly for him!
    Me: 35 | DH: 42 ~ TTC May 2015 thru Dec 2017
    5/16 - Began Creighton Method CM Tracking / Napro Fertility Medicine | Progesterone + various abx cycles - all BFNs
    8/16 - SHG: ute good, at least one tube open | 10/16 - MFI Azoo dx confirmed. No known genetic cause. Vas deferens absent.
    3/17 - DH started Clomid to prepare for MESA/TESE | 4/17 - Initial RE Consult for me. | 7/17 - Successful retrieval for DH!
    9/17 - Two BTB IVFs  | 10/17 - Polypectomy  |  11/17 - 1st FET ended in CP | 12/17 - 2nd FET ... BFP!!! <3 EDD: 09/09/18

    Our little miracle is finally here!


  • @BusinessWife - DH had one more "cup test" this morning to make sure there aren't any stray swimmers, but his doc ended up canceling the biopsy for the end of the month since he wants to get us started with the fertility center right away now that we have the diagnosis. I'm sure they will reschedule a biopsy at the fertility center to double check before we start the procedures. That would be AMAZING if we got 6 vials.

    @HottLemonade2886 was totally right. Our only option is IVF with ICSI, but the doc is optimistic.
    Me: 35 DH: 28
    TTC since June 2016

    Azoospermia diagnosis (zero count) Dec 2016

    AZFc chromosome microdeletion discovery March 2017
    Unsuccessful TESE for DH in August 2017
    October 2017 IVF with donor sperm
    29R, 24M, 16F, 2d5, 4d6 (6 embryos total)
    Only 3 could have PGS. 2/3 normal. 5 embies frozen
    12/15/17 FET #1 (1 embryo)--CP
    2/7/17 FET #2 (2 embryos)--BFN
    Chronic endometritis diagnosis May 2018
    ERA Sept 2018--borderline receptive--12 more hours of progesterone
    Abnormal SIS Oct 2018
    Repeat hysteroscopy Nov 1. Treated recurring endometritis.
    FET #3--December 4
    ~*~*~Nevertheless, she persisted~*~*~
    BusinessWife
  • good luck!!! I hope it goes really well and isn't super painful for him. I had a friend that went through this. he said to limit a ton of athletic activity after the biopsy
    • Me: 36 DH: 33
    • TTC since June 2016
    • Me: PCOS DH: Morphology 1%
    • 3 TI with Famera and trigger shots-BFN
    • 3 IUI's with Famera and trigger shots- BFN
    • IVF August 2017 25 eggs retrieved, 19 mature, 13 fertilized (ICSI), 5 frozen, 3 PGS normal 
    • FET November 2017 Transferred one 6 day blast (a little GIRL) BFP EDD 8/4/18

    BusinessWife
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