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refreezing defrosted embryos

zeynsomzeynsom member
in Infertility
OK, maybe this is a stupid question but I am curious: I have one frozen embryo on ice now (not PGDed). Let's say we do freeze all this cycle (again without a PGD). Then, when we are ready for the FET, can they defrost all, do PGD on all, transfer however many they think is appropriate and then refreeze the rest of the genetically good ones? Is defrosting and refreezing something they commonly do? I probably won't have enough embies to worry about this but I am just curious.

---- Siggy warning ------

Me 34 y/o  DH 35 y/o

IVF#1 (ICSI)-- April 2014-- MDL with BCP, 5R, 4 ICSID, 3dt with three embryos, 1 six-day freeze (2BA grade)-- BFN

IVF#2.1 (ICSI)-- August 2014: MDL without BCP-- cancelled

Natural IUI on 11/8 -- BFN

IVF#2.2 (ICSI)--Nov/Dec 2014: MDL without BCP, 5R, 1 ICSID, frozen on day 6 (grade 2BB)

FET #1: transferred two 5 (or 6?)day embryos on January 27. Beta #1 (2/4): 158, Beta #2 (2/6): 391 Beta #3(2/9): 1187 BFP! 

First u/s at 5w1d showed one gestational sac and yolk sac. Second u/s at 6w showed heartbeat at 102. Third u/s at 7w heart rate 145. EDD 10/15/2015


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Re: refreezing defrosted embryos

  • mrs.williemrs.willie member
    I'm not sure what they do for PGD and freezing, but I did a freeze all cycle without PGD. I was only transferring one at a time, so one embryo was frozen in each. They said if it didn't survive the thaw, they would take another out and the thaw could be done fairly quick. I know it's common to freeze in batches of two, but not sure if they refreeze one if only one is transferred. Good luck!

    MC Sept '10, MC Dec '10, DS born 2012

    Clomid + TI = BFP #1 March '13, MC April '13

    Gonal F + trigger + IUI #1 = BFP #2 10/21/13, MC 10/31/13

    Gonal F + trigger + IUI #2 = BFP #3 1/16/14, ectopic w/ heartbeat & rt salpingectomy 1/29/14

    IVF #1 - ER 5/9/14 transfer cx'd due to high P4

    FET #1 -  6/26/14 transferred 1 AA blast BFP!! Beta #1 13dp5dt - 1548 Beta #2 15dp5dt - 2748 Beta #3 18dp5dt - 7586

     

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  • LundleBeanLundleBean member
    It can be done.  Just know that with each process there is a risk.  A certain percentage will survive freezing, a certain percentage will survive thaw, and a certain percentage will survive refreeze.  That said, you could absolutely come out with all of them being okay. The survival rates are actually pretty high.  Good luck!
    Siggy Warning BFP/Loss Mentioned
    Me: 30, DH 30 Started TTC 7/2009
    9/2010 SA=Normal 9/10 HSG Dx Both tubes dilated; Rx bilateral salpingectomy & IVF; 9/2010-12/2012 Financial break
    1/2013 Bilateral Salpingectomy 5/2013 Recent SA shows borderline morphology
    5/2013 IVF w/ ICSI #1 6/25/13 ER=11R 9M 9F  6/28/13 3dt of 2 embies (8B & 6A-); no frosties: BFN
    10/2013 IVF w/ ICSI #2 11/12/13 ER= 9R 6M 6F  11/15/13 3dt of 2 embies (8A & 8A) 3 frosties (2 day-5, 1 day-6)
    11/22/13 (7dp3dt) +hpt  11/26/13 (11dp3dt) BFP Beta=141 11/28/13 Beta 2= 372 EDD 8/5/2014
    3/20/14 Fetal Demise 20 wks F/L 17 wks D&E attempted 3/21/14 & 3/22/14 Born Still 3/23/14  I love you B.T.
    "Sometimes you try your hardest, but things don't work out the way you want them to." –Nani (Lilo & Stitch)
    “All I can say is, it's a sort of kinship, as though there is a family tree of grief. On this branch, the lost children, on this the suicided parents, here the beloved mentally ill siblings. When something terrible happens, you discover all of the sudden that you have a new set of relatives, people with whom you can speak in the shorthand of cousins.” ― Elizabeth McCracken
    imageimageimage
    8/2014 FET 8/7/14 Transferred 1 5-day blast (4AA): BFN
    image
    TTCAL September Siggy Challenge:  Animals in Clothing

    Will add soon

    **All AL/AIF Welcome**
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  • ExoticAntibioticExoticAntibiotic member
    We're about to thaw, biopsy, and refreeze an embryo. My RE didn't tell me what the risk was, but just said there was a small chance that we'd lose the embryo. I think it's worth the testing, but you might prefer to just transfer it. It's a hard choice.
    TTC #1 since 2011 · Me (35, PCOS, AMA, abnormal eggs) and DH (47, MFI)
    2012-2013: 3 Clomid cycles, 3 IUIs, all BFNs
    IVF #1 January 2014: 14R/12M/9F 1 transferred, 3 frozen = BFN
    FET #1 March 2014: 1 transferred = BFFN · FET #2 May 2014: 2 transferred = BFFN
    IVF #2 June 2014: 24R/11M/10F 6 PGS tested: 1 normal embryo, 1 with no result
    FET #3 in March 2015: 2 transferred = BFFN
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  • Sunny BSunny B member
    My RE will defrost and then refreeze if necessary.
    TTC since May 2012
    Me: 32 H: 31
    DX: MFI-Very Low Count, I have Hashimotos.
    IVF prep September 2013 cancelled due to Ovarian Cyst
    IVF #1 October 2013 Antagonistic Protocol with ICSI  ER 10/31/13 (18R 16M 11F- 6 blasts to freeze)
    ET delayed due to OHSS 
    FET scheduled for July 8. Delayed due to a crazy high TSH (it had been under control for YEARS!)
    FET #1 8/5/14 sET BFN 

    All welcome!
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  • O2girlO2girl member
    My new RE wants to thaw, PGD, and re freeze my 6 embies. He said that the risk for arrest increases with the second thaw, but he said the chance with strong embryos surviving is at about 97% the second thaw vs the 99% with the first thaw. So the risk is pretty minor.
    Me: 38
    DX:  Adenomyosis, Compounded MTHFR, PAI-1 4G variant

    DH: 34
    MFI due to Testicular Cancer

    Married March 2012 <3
    IVF w/ICSI #1
    10 little polar bears
    FET #1 with 2 polar bears ~Nov 6, 2013 BFN :(
    FET # 2 with 2 more polar bears ~March 19, 2014 BFP!!!
    Beta 1= 276
    Beta 2= 662
    4/19/14 ~ baby A became an angel
    5/02/14 ~ baby B became an angel
    5/3/14 ~ D&C
    FET #3 with 1 male polar bear ~October 3, 2014
    October 13, 2014 ~ BFN
    Fur Children:  Memphis 3y, Dutch 3y, Marcel 2y, Meadow 1y



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    January 2015 Siggy Challenge TTCAL
    Animals Interacting with Snow

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  • zeynsomzeynsom member
    Thank you, all. I'll keep you posted on what my RE says on the topic. Do you also find it hard to reach to your RE? She was there for the very first appointment, and then for the WTF appointment. That is it. All communication happens via the nurses. I hate it. 

    ---- Siggy warning ------

    Me 34 y/o  DH 35 y/o

    IVF#1 (ICSI)-- April 2014-- MDL with BCP, 5R, 4 ICSID, 3dt with three embryos, 1 six-day freeze (2BA grade)-- BFN

    IVF#2.1 (ICSI)-- August 2014: MDL without BCP-- cancelled

    Natural IUI on 11/8 -- BFN

    IVF#2.2 (ICSI)--Nov/Dec 2014: MDL without BCP, 5R, 1 ICSID, frozen on day 6 (grade 2BB)

    FET #1: transferred two 5 (or 6?)day embryos on January 27. Beta #1 (2/4): 158, Beta #2 (2/6): 391 Beta #3(2/9): 1187 BFP! 

    First u/s at 5w1d showed one gestational sac and yolk sac. Second u/s at 6w showed heartbeat at 102. Third u/s at 7w heart rate 145. EDD 10/15/2015


    image

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  • MargritliMargritli member
    @O2girl, thanks for posting those percentages. I never knew that that was possible or what the associated risks were like.

    Me: 28, DH: 35
    DX: Severe MFI, AZFc Microdeletion
    TTC since August 2011
    IVF w/ ICSI 1: Dec. 2013 - BFN
    FET 1.2: Mar. 2014 - BFN
    FET 1.3: May 2014 - BFN
    FET 1.4: June 2014 - BFP
    Two little buns in the oven. 
    Bake until March 2015, little ones. 


    "Life will be clearer around me.
     Life will be more burdensome for me. 
    Life will be richer for me." 
    -Rudolf Steiner
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