PIO or cronine jel

zeynsom

I am 1dp3dt of fresh ivf with ICSI and have been on cronine for once a day since Saturday. The doctor told me that there is no difference between PIO and Cronine for their effectiveness. But I see that many of you are on PIO. Why? The reason I am on cronine is because my husband lives in a different city, miles away, and I am very incompetent about giving myself shots. But if it is necessary I may try to find a nurse or clinic every day to get it done. I just do not want to risk anything. Is it only because cronine is gross that you all chose PIO or is it really more effective?

doglover1234

My doctor has the same stance as yours and says that they haven't seen much difference between the two, so they put almost everyone on crinone bc it's so much easier. GL!

LooneyLife

I never used Crinone. My RE prescribes Endometrin suppositories for fresh transfers. They prescribe PIO for frozen because it has a better absorption rate. After a heartbeat is seen, they allow you to switch to the suppository (although I think I'd stick with the PIO).

pjpahel

My office uses prometrium primarily, but I had a reaction to it, so I have used Crinone.  From what I have read statitically speaking there is no benefit to PIO over Crinone for most cases.

 

Pj

SKLH

I've been to two different RE's. One says there was abosolutely no difference. My current RE says PIO is better for FETs b/c your body is not naturally producting any progesterone so PIO is able to be absorbed better. During FETs I actually take both progeterone suppositories (endometrin) AND PIO.

Spring78

My doctor is strictly for PIO until some time after a positive beta. Not sure why -- I never asked. She has been doing IVF for over 30 years, so has a whole lot of experience. I would assume she has a reason, especially since she is willing to allow a switch to another form after a pregnancy is established. I think I will ask the next time I talk to her.

zeynsom

@Spring78 Thanks! I wonder whether it is only required for FET or also for fresh cycle. My reading is that for FET PIO is a must while for the fresh cycle they say no difference

Rebecca'sMama

I am on both PIO and Endometrin, post ER (fresh transfer). My RE likes double coverage apparently, because I am also on both Vivelle and Estrace.

ikrystal

I'm not sure why they choose one over the other, but I know I was on Crinone for my fresh cycle and will be on PIO for my frozen cycle.  I think Crinone is their progesterone of choice for most, though.  I wouldn't worry too much.  Good luck!

diamante1181

My first RE had me do PIO. Second RE Crinone and progesterone pills orally. I got pg the first time doing the Crinone, therefore I believe there is no real difference other than delivery method. I also have not heard about "better absorption", which if it came down to a best guess, I would assume crinone had faster absorption because it is in "there", if ykwim... Food for thought!