I know this has been asked before (but I suck at searching on TB) so I
wanted to ask again since all the posts I found are 2010 or older and
science moves forward every day.
We are scheduled with an MFM on
Monday for our 1st tri (NT/bloodwork) appointment. My last pregnancy was
a singleton and it seems the rules are different with multiples. I have
done some googling and what I am hearing is that the blood tests for
1st tri are out with multiples (Mat21, Panorama, etc.) and that a CVS or
amnio is the only way to go if you want any results. Has this been your
experience? I am over 35 and IVF but nothing else points to a high risk
for genetic disorders based on our history, I have just naively assumed
to this point that the test would be the same as with my DS. If a CVS
or amnio is our only option, DH and I need to discuss prior to Monday
and this has never come up before so it isn't even on our radar. Just
don't want to be blindsided by the counselor.
Any advice or experience is appreciated!
Me: 37 DH: 40 TTC since 9/09
#1 BFP 1/10/11; missed m/c discovered 7w5d IF Dx: Endo, hetero MTHFR mutation, poor morphology #1 IUI: 1/18/12 = BFN #1 IVF/ICSI 4/2/12 = 2 x 7-cell and 1 x 5-cell transferred (3dt) = BFP!!
H was born at 41w2d on 12/29/12 - be still my heart! #2 IVF/ICSI 1/19/14 = 2 x 8 cells transferred (3dt) = BFP!! EDD 10/09/14 M&W born at 37 weeks on 9/18/14 - I am the momma of 3 boys!!!
You can still have the sequential screen and NT scan in your first trimester without the cell free DNA testing (MaterniT21, Harmony, etc.). If your risk comes back higher than expected because of one of your blood results (i.e. HCG) then you could reflex to one of the cell free DNA based tests which actually looks at the babies' individual DNA sequences from your blood. They are a lot more accurate (99%) than the NT/sequential screen results.
***SIGGY/TICKER WARNING***
TTC since September 2012 ~ DH(32): Non-obstructive azoospermia, Me(32): Normal
10/13 - TESE found sperm!! ~ 11/13 - IVF w/ ICSI #1 ~ ER 11/23/13 ~ 10 R, 9 M, 8 F
ET 11/29/13 ~ Transferred 2 beautiful hatching blasts, 5 frosties
I appreciate the feedback! I thought it would be too, but my OB mentioned yesterday that it may not be so that got me thinking (and googling). I will have to wait and see what the GC and MFM say, but I was kind of shocked that it wouldn't be possible.
Me: 37 DH: 40 TTC since 9/09
#1 BFP 1/10/11; missed m/c discovered 7w5d IF Dx: Endo, hetero MTHFR mutation, poor morphology #1 IUI: 1/18/12 = BFN #1 IVF/ICSI 4/2/12 = 2 x 7-cell and 1 x 5-cell transferred (3dt) = BFP!!
H was born at 41w2d on 12/29/12 - be still my heart! #2 IVF/ICSI 1/19/14 = 2 x 8 cells transferred (3dt) = BFP!! EDD 10/09/14 M&W born at 37 weeks on 9/18/14 - I am the momma of 3 boys!!!
My MFM had me do the Mat21 last week, but said if there is an issue the only way to know which baby has it would be an amnio. I had the NT scan and sequential screen already but due to my girl being so small they wanted to do the Mat21.
***signature & ticker warning***
Me: 30 ~ Stage IV Endo ~ AMH .38 ~ AFC 8 AMH .97 as of 4/2012! ~ AMH 1.63 as of 4/2013!?! Him: 29 ~ perfect swimmers Laparotomy w/partial oophorectomy 8/2009 to remove cysts/endo. Stopped BCP 4/2010. Multiple clomid rounds from 11/2010 to 6/2011. ~ All BFN IUI w/clomid 7/2011. IUI w/clomid & injectables 11/2011 & 1/2012. ~ All BFN IVF:EPP 5/2012 ~ (4R, 3M, 2F w/ICSI). Both embryos txfrd. ~ BFN BCP to manage endo from 10/2012 to 12/2012. FET w/donor embryos #1: 10/2013 Cancelled FET w/donor embryos #1.2: 11/2013 ~ ET of 2 beautiful blasts on 11/27. Beta 1: 503(12dp5dt) Beta 2: 1035(14dpt) Beta 3: 3001(16dpt) Beta 4: 8503(19dpt) Twins with an EDD of 8/15/14! Team Purple G&B born 6/30/14 at 33w3d via emergency c/s. If you're wondering about my avatar...it's a fried pickle chip shaped like a fetus!
We just did the nt & sequential screen. Nothing different was offered to us but I'm only 29.
"Everything will be alright in the end. So if it's not alright, it is not yet the end." Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
Feb'12- July'12-testing(all clear minus slight arcuate ute), 3 IUI with clomid all BFN 8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
ET 9/14 2 embies transferred. 1 10cell Grade 4, 1 8cell Grade 4. No frosties. BFN IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F! ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN 3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
DX: High NK cells, cytokines, DHEAs& PAI1; hypothyroid, +APA, restricted bloodflow
7/13 IVF#3 Long lupron protocol with PIO, Crinone, Prometrium, and vivelle
(plus synthroid, metformin, baby asa, metanx, PNV, Vit E, D, calcium, fish oil, CoQ10, IVIg infusions and lovenox per Dr. Kwak-kim) ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI) ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!! Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
11/11: TEAM PURPLE!!!!! 3/21/14-L&W born at 37w via csection Here Comes the Sun Blog PAIF/SAIF welcome!
Hey according to sequenom who makes Mat21 and my friend who works with the test in his job, it is accurate for multiple gestations, but as PP said it cannot tell which twin has the problem if a problem is found. For finding out the sex, it can only tell presence or absence of a y chromosome. In our case it was an absence - two girls! And that was confirmed by a recent US.
Re: (XP from Multiples) Q: 1st tri screening for twins
***SIGGY/TICKER WARNING***
TTC since September 2012 ~ DH(32): Non-obstructive azoospermia, Me(32): Normal
10/13 - TESE found sperm!! ~ 11/13 - IVF w/ ICSI #1 ~ ER 11/23/13 ~ 10 R, 9 M, 8 F
ET 11/29/13 ~ Transferred 2 beautiful hatching blasts, 5 frosties
12/5/13 - BFP!!! Beta #1 (12/7/13) - 189 Beta #2 (12/9/13) - 401 Beta #3 5871
12/16/13 U/S #1 - TWINS!! EDD - August 16, 2014 ~ 7/19/14 - Our beautiful baby girls joined the world!
#1 BFP 1/10/11; missed m/c discovered 7w5d
IF Dx: Endo, hetero MTHFR mutation, poor morphology
#1 IUI: 1/18/12 = BFN
#1 IVF/ICSI 4/2/12 = 2 x 7-cell and 1 x 5-cell transferred (3dt) = BFP!!
H was born at 41w2d on 12/29/12 - be still my heart!
#2 IVF/ICSI 1/19/14 = 2 x 8 cells transferred (3dt) = BFP!! EDD 10/09/14
M&W born at 37 weeks on 9/18/14 - I am the momma of 3 boys!!!
***signature & ticker warning***
Me: 30 ~ Stage IV Endo ~ AMH .38 ~ AFC 8
AMH .97 as of 4/2012! ~ AMH 1.63 as of 4/2013!?!
Him: 29 ~ perfect swimmers
Laparotomy w/partial oophorectomy 8/2009 to remove cysts/endo.
Stopped BCP 4/2010.
Multiple clomid rounds from 11/2010 to 6/2011. ~ All BFN
IUI w/clomid 7/2011. IUI w/clomid & injectables 11/2011 & 1/2012. ~ All BFN
IVF:EPP 5/2012 ~ (4R, 3M, 2F w/ICSI). Both embryos txfrd. ~ BFN
BCP to manage endo from 10/2012 to 12/2012.
FET w/donor embryos #1: 10/2013 Cancelled
FET w/donor embryos #1.2: 11/2013 ~ ET of 2 beautiful blasts on 11/27.
Beta 1: 503(12dp5dt) Beta 2: 1035(14dpt) Beta 3: 3001(16dpt) Beta 4: 8503(19dpt)
Twins with an EDD of 8/15/14! Team Purple
G&B born 6/30/14 at 33w3d via emergency c/s.
If you're wondering about my avatar...it's a fried pickle chip shaped like a fetus!
Me:29 DH:29 TTC since 1/11 Dx: unexplained IF/early DOR/immune issues
8/30IVF#1 Antagonist protocol- ER 9/11-8R, 7M, 5F.
IVF#2 Antagonist protocol plus baby aspirin- ER 12/5-16R, 12M, 8F!
ET 12/10 5dt! 1 fully expanded blast & 1 early blast. No frosties. BFN
3/13 hysteroscopy & polypectomy, Consulted w Dr. Kwak-Kim.
ER 7/19 14R, 11M, 9F(4 natural fert, 5 with ICSI)
ET 5dt 7/24 2 fully expanded blasts. SURPRISE 3 FROSTIES!!!
Beta #1 8/2 335!!!! Beta #2 829!!! 1st u/s 8/14 showed TWINS!!!!!
3/21/14-L&W born at 37w via csection
Here Comes the Sun Blog
PAIF/SAIF welcome!