Follistim Pen Question — The Bump

Follistim Pen Question

Hello Ladies! So, I am in the process of doing my first IVF cycle. And this is all really new to my husband and myself.  My question is how do I know when the Follistim Pen is empty? I know my nurse said it will stop but my problem is on the box it says 600. And I have been doing 225 for 3 days and today I did 150. But every time I give myself the shot it hasn't stop once. I know there are overfills but I feel like this is too much and I should switch the cartridge out. Confused... And I just hope I haven't messed something up. Any advice?

Re: Follistim Pen Question

  • That does seem like a lot of overfill and the pen should stop. The most overfill I've gotten is 150. I would take the pen apart and remove the cartridge. I'm guessing it will be empty!
    Me: 30 DH: 30 ~ TTC #1 Since August 2011 
    BFP #1 2/28/13, Ectopic, Tubal surgery 3/25 
    Began RE testing 8/8, Dx Unexplained, 
    IUI #1 11/1=BFN Moving on to IVF 
    IVF #1 12/2 ER 8R 7M 4 fertilized
    12/7 Transferred 2 "perfect" little blasts 12/17 BFN
    New DX= DOR, I fu*kng hate IF
    1/14 Hysteroscopy, new clean uterus!
    IVF #2: bcp, Lupron, follistim 300, menopur 225. 2/21 8R 4M 3F. 3dt of 2 perfect embryos. 1 little penguin 
     3/10 BFFN
    Regrouping. Seeing reproductive immunologist Dr. Kwak Kim 6/10 
    Kwak Kim protocol: Metformin 1000mg, vitamin D 4000iu, vitamin E 400iu, baby aspirin, Metanx, levothyroxine 75mcgs 
     Surprise BFP 9/21!!! Beta #1 247, Beta #2 630. Miscarried 10/13

  • They tend to overfill the cartridges by a lot, so you're good :) I've always had at least 150iu of overfill, sometimes more.

    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
           Protein S Deficiency, Sjorgen's Syndrome 

    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN

    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently PREGNANT!!!!!!
    Synthroid + Prednisone + Metformin + Baby Aspirin + Supplements Galore = 15+ pills a day
    Lupron + Lovenox + Delestrogen + IVIG + B/W = 2-5 pokes a day
    19R, 17M, 17F - transferred two Grade A blasts 11/16, four frosties!!!
    Beta #1 11/24 (13dpo/8dp5dt) = 367 ~ Beta #2 11/26 (15dpo/10dp5dt) = 709
    Beta #3 11/29 (18dpo/13dp5dt) = 1,997 ~ Beta #4 12/1 (20dpo/15dp5dt) = 3,403


    My Blog: Running and Dreaming for Two ~ All are Welcome!
  • I also did 225 iu on the 600 & got 3 full shots and a 75 iu as the last one. It's weird, like they measured way off ... Go figure...

  • Thanks ladies. I am just a little nervous because that is 225 over. But when I took the needle there was still liquid coming out of the needle. I am for sure going to switch it out tomorrow. I just hope I have done everything right.
  • There is a grey plunger in the vial. Look at it and move the vial around and see if there is still liquid in it.
    The pen will stop when it's empty if you don't get the full dose it won't be at zero
    Me 39, DH 40
    Male Factor (severe oligospermia) 
    IVF#1-December 2013: Conversion Protocol @ SIRM, Canceled on day 10 of stims due to poor response
    IVF#2- February 2014:  Estrogen Priming Conversion Protocol @ SIRM (ER 2/22: (9R, 7M, 4F, All arrested, nothing to trasnfer)
    IUI#1-May 28, 2014- 100mg clomid, HCG Trigger, 100mg progesterone oral--BFN
    IUI#2-June 24, 2014- non medicated, HCG 2,500mg x 4 doses (over a week), Endometrium- BFN
    Suprise BFP- September 1, 2014- miscarriage at 5 weeks. 

  • I'm completely out of pocket for meds and the cycle itself so we have been doing everything to cut corners, have been taking what is left over in the cartridges to make up full doses in the little insulin needles they give you for Lupron. So far I am on day 8 and I am on 300 ui a day. For those day I have used 4 of the 300 ui cartridges, 1 600 ui cartridge and I've been able to make up two full 300 ui doses from what is overfill in the cartridges. So that's a total of 600 ui overfill between 5 cartridges plus I still have some left in one of the cartridges too. So there's my experience for what it's worth! I often wonder why they don't just have us draw up the medication into a needle rather than messing around with that pen. No idea why...
  • I was not aware of the overfill in Follistim pens so when I finished my first full cartridge & realized there was still some in there, I drew it up with a needle & injected it as I thought the full dose did not come out!  My nurse was not happy with me!

    Me (36) - LOR, DH (34) - MFI (low count & poor motility)

    TTC since 01/2012

    11/2012-04/2013 Unmonitored Clomid cycles through OB/GYN; Referred to RE

    05/2013-Benched due to cyst

    06/2013 - Clomid 50 mg + HCG Trigger + TI = BFN

    07/2013 - Clomid 50 mg + HCG Trigger + IUI #1 = BFN

     08/2013 - Clomid 50 mg + HCG Trigger + IUI #2 = BFN

    09/2013 - Benched for lap & hysteroscopy (Stage II Endo Removed)

    10/2013 - Menopur + HCG Trigger + IUI #3 = BFN

    11/2013 - Menopur + HCG Trigger + IUI #4 = BFN

     12/2013 - Clomid + HCG Trigger + IUI #5 = BFN

    2/2014 - IVF #1 - Microdose Lupron Flare Protocol - 5R/4M/4F w/ICSI; 2 embies transferred on day 3 (none to freeze)

    2/27/14 - First BFP Ever!!!  EDD 11/3/14








  • I learned after the first set that there usually is extra and just about my whole dose. 225iu. (Or more) When I didn't have that much in the pen you couldn't push it in anymore and had to change cartridges.
    TTC Since 2012
    Me: Endo Stage IV (20+yrs) (who knew? Not me)
    MyLove: Pretty Ok. Low #s (i think) 
    IVF#1: No Eggs to Retrieve
    Taking time to ourselves
     Poor Responder will add COQ10 & DHEA next cycle
    **All Welcome**


  • Usually get about 100-150 in overfill, don't waste the overfill.
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