Q about IVF & risk of placental abruption — The Bump
Pregnant after IF

Q about IVF & risk of placental abruption

My doctor said to me at our u/s yesterday to get ready to talk about labor and delivery at my cervix check next week. He also mentioned that IVF pregnancies have a higher chance of placental abruption, which can lead to stillbirth without any warning, and that it may be a good idea to consider inducing ~1wk prior to my EDD to minimize this risk.

Does anyone know anything about this? I felt a little bit blindsided by this info since I hadn't heard about it before. I was hoping to avoid inducement, but I really trust my doctor, too. I'm working on doing some independent research on this but thought I'd come here to find out if any of you have heard of this.
*** Trigger Warnings ***

TTC #1 since March 2011
Dx = Unexplained IF
1 medicated TI cycle & 4 clomid IUIs = all BFNs
June 2013 IVF #1 = 6 frosties + BFP!
DS1 born 2/14

TTC #2 since December 2014
May 2015 unassisted BFP ended in m/c at 7wks
April 2016 FET #1 = BFN
June 2016 FET #2 = c/p
August 2016 FET #3 = BFP!
DS2 born 4/17

Re: Q about IVF & risk of placental abruption

  • Interesting- I never heard of that correlation but I will ask my OB at my next appointment!
    Me 36/DH 46 Me: Low AMH (.21) DOR, mild endo; Started seeing RE 11/12
    Jan-March '13 3 IUIs Clomid + Trigger = BFN
    April '13 IVF 1 MDLF converted to 4th IUI due to 3 runaway follicles! BFN
    July/Aug '13 IVF 1.2 Long Lupron = 7R, 6F, 2T= BFP!!!
    Beta 1=512, Beta 2=1,368 Beta 3= 4,128
    It's a boy!!!!
    SUA, GD
    EDD 4/26/14

    He's Here! Arrived 4/15/14!!!!

    September 2015 - FET with remaining embryos
    Twins! EDD: 6/14/15

    PAIF/SAIF Everyone welcome!
  • I haven't head hear nor tell about this either.  The NP as my m/w practice used to be an IF nurse, so I feel like this is something she would have told me when I asked last time if there was anything else related to IVF that would put me at higher risk or to worry about. 
    Me 31 ~ DH 30
    IVF/FET #1 - BFP!!
    <3 CJW 6/15/2014 <3
    DX - PCOS 2004
    FET #2 - scheduled for 11/24/15
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  • I've never heard of this, from any of my medical team (RE or OB), from any of the literature I've read, or from any of the other IVF ladies on these boards. I'm kind of giving your OB the side eye...

    TTC #1 since 2011

    Me: 36, anovulatory PCOS; DH: 34, fine

    Sophia Juliet conceived through IVF and born April 15, 2014

    Lilypie First Birthday tickers
  • So far, I've found a study that shows that IVF pregnancies are 2.5x more likely to have this problem than other pregnancies. Hmm.
    *** Trigger Warnings ***

    TTC #1 since March 2011
    Dx = Unexplained IF
    1 medicated TI cycle & 4 clomid IUIs = all BFNs
    June 2013 IVF #1 = 6 frosties + BFP!
    DS1 born 2/14

    TTC #2 since December 2014
    May 2015 unassisted BFP ended in m/c at 7wks
    April 2016 FET #1 = BFN
    June 2016 FET #2 = c/p
    August 2016 FET #3 = BFP!
    DS2 born 4/17
  • Does is say what risks are normally? Is it a small percentage?
    Me 36/DH 46 Me: Low AMH (.21) DOR, mild endo; Started seeing RE 11/12
    Jan-March '13 3 IUIs Clomid + Trigger = BFN
    April '13 IVF 1 MDLF converted to 4th IUI due to 3 runaway follicles! BFN
    July/Aug '13 IVF 1.2 Long Lupron = 7R, 6F, 2T= BFP!!!
    Beta 1=512, Beta 2=1,368 Beta 3= 4,128
    It's a boy!!!!
    SUA, GD
    EDD 4/26/14

    He's Here! Arrived 4/15/14!!!!

    September 2015 - FET with remaining embryos
    Twins! EDD: 6/14/15

    PAIF/SAIF Everyone welcome!
  • So far, I've found a study that shows that IVF pregnancies are 2.5x more likely to have this problem than other pregnancies. Hmm.

    2.5x a miniscule chance might not be enough to justify the risks of an induction (which raises the odds of a c section). I'd have to know a lot more before consenting to an induction.

    My OB has never mentioned this.
  • My OB is very cautious with my pregnancy because of IVF and has never brought this up and when I asked him about potential problems he didn't mention this ether. I would honestly get a second opinion. You don't have to switch OBs but just get another opinion from some one else in the practice or a different office.
    Me: 24 w/ PCOS, DH: 30 w/ MFI
    IVF #1 14 Retrieved, 10 Mature, 8 Fertilized, 1 frozen (4BB)
    3 day transfer of one 8 cell embryo BFN
     IVF #2 14 retrieved, 12 mature, 9 fertilized, 3 frozen (5AB)
    3 day transfer of two 8 cell embryos
    Beta #1 9/19 BFP 90!! Beta #2 9/24 657!! Beta #3 10/01 6,899!!
    1st U/S 10/08 showed one baby with a HB of 122 <3
    PAIF/SAIF Welcome

    imageimage 
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  • Never heard of this either. Are you having weekly NSTs or any kind of other monitoring late in the game?

    My doc talked about induction only at or after 41 weeks, which is reasonable to me given my age and the placenta eventually giving out anyways.
    BzeetyD = 38, Mr. BzeetyD = 44 together 12/02 married 9/08
    TTC #1 since 1/10
    DX: Unexplained/??? MFI issues

    Our lil' lost sparks:
    5w3d loss 7/30/10 - EDD March 2011
    8w loss 4/15/11 - EDD November 2011
    8w3d loss 8/2/12 - EDD March 2013
    4w c/p loss 10/29/12 - EDD July 2013

    Long story: trying on our own + testing testing testing with 6 rounds of Clomid, more testing, injectables + TI, laparoscopy - one tube blocked, 2 IUIs with Follistim...BFNs.
    RPL testing all normal, Karyotyping normal

    Moving on to IVF.

    IVF #1 April 2012 = BFN, IVF #2 June 2012 = BFP. U/S 7/23 = saw heartbeat but measuring behind. Follow up U/S on 7/30 - no heartbeat. D&C 8/2. Trisomy 12. IVF #3 Oct 2012 = Chemical Pregnancy

    Phone consult with CCRM on 12/12/12 - ODWU 1/4/13 - both tubes clear(!) - AFC 24, AMH 3.2, FSH 9.6, LH 5.4, E2 25. DH has high frag rate but improved!
    IVF #4 March 2013 CCRM. EP protocol w/ Menopur, Gonal-F & Dexamethasone. ER 3/29 & IMSI, PICSI. 43R 13M 10F 6blasts bio'd. CCS testing reveals 3 normals!!!
    FET 5/31/13 of 1 4AA blast - thawed and expanded. 4dp5dt BFP.
    Beta 9dp5dt = 181, 11dp5dt = 427. 1st u/s showed a healthy heartbeat! EDD 2/16/14

    After 4 years of hoping and heartbreak, our sweet little bean was born on 2/19/14
    We are so in love with her.

    "I'm not telling you it's going to be easy, I'm telling you it's going to be worth it."

    Everybody is welcome!!!
  • Strange.  I'm on IVF pregnancy #2 and as with #1 I see an OB and a Perinatologist (I am old! 38 now!!) This has never once been mentioned to me by either of them (or my RE)  And believe me, my perinatologist is not shy about telling me about ANY risks.  Seriously, she should just change her name to Dr. Scary ... She's like the LEAST reassuring woman I've ever met.  I don't think she's read about a single complication or risk in her whole life that she didn't feel necessary to "talk" to me about.  (to be fair, I don't mind - she's incredibly bright and well respected and I'm not one to need sunshine and roses all the time)
  • If I understand what I'm reading correctly, the normal chance is slightly <1%, so the risk for IVFers is maybe ~2%? Not a huge number, but even a small number is scary when you're talking about possible stillbirth... :(

    Anyway, thanks for the feedback, everyone! I love this board. I will definitely be raising some further questions with my doctor next week. I really want to avoid induction. Hopefully I can do some more research and get some answers from my doctor so that I can make the right decision for me and the baby. I'll let you all know if I find out anything that the board may be interested in.
    *** Trigger Warnings ***

    TTC #1 since March 2011
    Dx = Unexplained IF
    1 medicated TI cycle & 4 clomid IUIs = all BFNs
    June 2013 IVF #1 = 6 frosties + BFP!
    DS1 born 2/14

    TTC #2 since December 2014
    May 2015 unassisted BFP ended in m/c at 7wks
    April 2016 FET #1 = BFN
    June 2016 FET #2 = c/p
    August 2016 FET #3 = BFP!
    DS2 born 4/17
  • Induction comes with so many very well-documented risks in itself, that I would really encourage you to balance those risks against the ONE study you have found that shows an increased risk of this. Abruptions can also have a range of severity. Also, correlation with IVF is not the same as causation...simple because you did IVF doesn't mean that it can cause abruption. I am definitely side-eyeing an OB who suggests an early induction for any reason except medical necessity. This is NOT significant enough data or evidence to suggest induction, especially early induction! GL! 
    | Married since 2008 | DH and I: Both 30 | Me: Endometriosis and Carrier of an X-Linked Dominant Genetic Disorder | DH: Low Morph | Planning IVF with PGD and PGS in 2013 | Freeze-All IVF #1: March 2013 ER 3/26. 29R, 12M, 11F. 4 5AA frozen blasts. Freeze-All IVF#2: May 2013 ER 5/15. 31R, 21M, 20F. 6 5AA frozen blasts. Our PGD probe was completed in late June (total of 20 weeks to develop). PGD and PGS Results came on 6/19: 3 healthy embryos (normal chromosomes and unaffected by my family's genetic disorder). FET #1: July 2013 Natural Cycle - Cancelled due to insufficient lining (only got to 7.5mm). FET #1.2: August 2013 - Medicated Cycle with Lupron & Estrogen Patches to build up lining. Single embryo transfer was 8/23. Beta #1: 240! Beta #2: 578! U/S on 9/19 at 6w4d: We saw the heart beating at 131bpm. Second U/S on 10/4 at 8w5d: We saw the heart beating at 178bpm. EDD 5/11/2014
    image
    PAIF/SAIF/Everyone Welcome! 


    ld08271
  • I agree with PPs. This is also my second IVF pregnancy and I've put a lot of hours on boards. I've never heard of this at all.

    Here is what I do know from my OB: IVF pregnancies tend to have more preterm labors. It's only a slight increase, which is probably why you are getting the cervix checks. Also, IVF babies have a smaller increase of heart issues. They check for this at your 20w scan and I also get a 32 to check both heart and cervix.

    I'd question your doctor and I'd also question one study.
    IVF #1- BFP- DD 4/8/2011
    FET #1- 3BB and 3B-B
    Beta #1 (4w0d)- 504
    Beta #2 (4w4d)- 4,577
    Beta #3 (6w0d)- 78,399 HB 115 bpm
    U/S #2 7w0d- HB 155 bpm

    Lilypie First Birthday tickers Lilypie Fourth Birthday tickers




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