Infertility

has anyone had success with IUI and MFI?

My fertility eval was overall fine except for an arcuate uterus and AMH of 0.7.  Unfortunately my DH has run sperm counts from 2-11 million concentration, 25% motility, and around 50% morphology.  He was placed on clomid to help, but his testoterone was never abnormal so I don't know how much that will help.  We were advised by 3 fertility docs to go straight to IVF/ICSI but I am scared to death of doing it, very intimidated by the cost and the stats on IVF are discouraging at my age (37yo). 

However, we got pregnant on our own last year (and miscarried) so I KNOW it is possible for a sperm and egg to meet, which makes me still feel like theoretically IUI could work.  Has anyone with MFI ever had success with IUI?  I can't find much info online and I don't want to waste too much time pursuing hopeless treatments, but if there is any hope then I want to do IUI first before facing IVF.  Thanks so much, can't tell you how much help I have found just reading other posts!!

Re: has anyone had success with IUI and MFI?

  • I can't speak to IUI, but my husband had similarly poor numbers (I'm 36 with no realy issues) and we were directed to IVF/ICSI, too. Our RE said that the IUI would have incredibly low odds of working. Since we are paying out-of-pocket and everything I read on-line seemed to state that IUI would be a waste with MFI (my acupuncturist who specializes in fertility treatments also cautioned against IUI as a waste because she said it never worked for her clients, but that IVF did), we went with IVF/ICSI in Jan. I didn't feel like the stats on IVF for 37 were that grim (I looked at the stats around my age) and my RE said we have a 60% chance of success. I'll find out on 2/3 if it works.

    I'm very sorry for your loss. Our RE did say that it wasn't impossible for us to get pregnant on our own, but that every month that passed that we weren't would make it less likely.

    Good luck with whatever you decide.

    ***************************Loss Mentioned***************************


    Me 37 y/o, DH 45 y/o; DH vasectomy reversal (his 2nd marriage) 11/8/12; TTC since 12/8/12. IVF due to MFI. DOR diagnosis April 2015.

     

    IVF #1 BCPs/Antagonist w/ICSI Jan 2014 = BFN

    IVF #2 MDL w/PICSI March 2014 = BFN

    IVF #3 EPP/Antagonist w/PICSI May/June 2014 = BFP!; MMC 6w4d

    IVF #4 No suppression/Antagonist Nov 2014/Converted to IUI #1 = BFN
    IVF #4.1 Feb 2015 = cancelled
    IVF #4.2 April 2015 - Lupron Stop Protocol with ICSI = PGD testing of embryo indicated it was abnormal
    IVF #5 June 2015 EPP with Antagonist 

     

    image
    Everyone welcome!

  • Most of us are trying for #1 and have moved onto IVF on this board. You might want to check with PAIF and SAIF if you're looking for success stories. Good luck!
    **SIGGY WARNING**

    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
           Protein S Deficiency, Sjorgen's Syndrome 

    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN

    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently PREGNANT!!!!!!
    Synthroid + Prednisone + Metformin + Baby Aspirin + Supplements Galore = 15+ pills a day
    Lupron + Lovenox + Delestrogen + IVIG + B/W = 2-5 pokes a day
    19R, 17M, 17F - transferred two Grade A blasts 11/16, four frosties!!!
    Beta #1 11/24 (13dpo/8dp5dt) = 367 ~ Beta #2 11/26 (15dpo/10dp5dt) = 709
    Beta #3 11/29 (18dpo/13dp5dt) = 1,997 ~ Beta #4 12/1 (20dpo/15dp5dt) = 3,403

    imageimageimage

    My Blog: Running and Dreaming for Two ~ All are Welcome!
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  • We have similar numbers as you do.  We tried 5 IUI's all unsuccessful.  We did 1 ivf so far and it ended in a chemical, that was the farthest we have ever gotten.  
    TTC 2007
    Me-OK DH- MFI
    2010 IUI 1-3 Femara + Ovidrill BFN
    Change DR 5/12 IUI 4-5 Natural Cycle BFN
    5/13 DH diagnosed with b1/b3 microdeletion of Y chromosome
    IVF #1 July  Started Lupron 7/5 AF 7/14
    ER 8/1 7R 5M 3F W/ICSI ET 8/6 Moved to 8/7 due to no blast 
    Transferred our UNO embryo Beta #1 27 Beta #2 33 Beta #3 29 CP :(
    IVF #2 Started Lupron 2/14 
    Protocol 10U Lupron, 150 Bravelle, 150 Menopur, HGH for 4 days, Dexamethesone, 
    Supplements 6000mg CoQ10, 100mg DHEA, Vitamin D, Folic Acid, 
    ER 3/12 8R 4 able to be injected 2f with ICSI ET 3/15 2 "perfect" textbook Embryos
    2 crinone, estrace, dexamethesone, doxycycline
    BETA #1 3/26 201  BETA #2 3/28 524  BETA #3 4/5 9,876  Ultrasound April 7 Showed TWINs
    April 18 ultrasound Baby A HB 147   Baby B HB 146  Both measuring 7w1d
    WE ARE TEAM BLUE X2!
    Jonathan Daniel received his angel wings July 23, 2014 :( born 9/20/14
    Jackson Thomas was born October 31, 2014 @ 35w 5d
    image



  • We have higher but still mfi numbers. Of our five IUIs one we got pg but mc. It was the only one where we had post wash count over 8 mil. If his highest sample has been 11 mil, his post wash count will be five mil or less so coupled with your age (I too am AMA) and other factors Ican uunderstand why they recommend IVF with ICSI. Sorry, I know it is scary but it is doable.

    TTC since July 2009. Dx MFI & LPD. 
    IUI#1&2&3 (2011 & 2012) BFN
    IUI#4 1/23/13 on 75iu x9 Follistim = BFP then chem preg m/c (Feb 2013)
    IUI#5 BFN (April 2013)
    IVF w/ICSI Oct. 2, 2012 - 13R, 11M, 7F, 1 frozen blast 4BB grade - - - FET Nov 15, 2013
    BFP! Beta 1:104 @ 10dp6dt, Beta 2:178 @ 12dp6dt,  beta 3:366 @ 14dp6dt
    Saw heartbeat twice before missed M/C at 8w3d on 12/27/13, missing my little angel boy
    JUNE 2014 IVF#2;  5R, 2M, 1F Three day transfer 6/7.  Beta 6/18 - BFN
    Child Free Now?
    S/PAIFW , S/PALW

    My Blog

    image



  • Unfortunately, not many women here have had success, but don't let that get you down. Everyone's story is different!

    I can speak to wasting time with treatments though. IVF was suggested to us early on because of my endo. My husband is fine (from what we know so far), but I'm a mess. However, I really thought we'd be one of the success stories without IVF. Well, what I learned, the hard and expensive way, is that most RE's don't push IVF unless it's really needed. There are some that do, but most would rather try less aggressive treatments first. Looking back, I regret not trying IVF sooner. If I could be in your shoes again, I'd do 3 IUI's because, why not try. Like you said, you did get pregnant, so that's a start. But, once you start adding injectables into an IUI cycle, it only takes 3 or so for the cost to add up to an IVF cycle. I learned that lesson the hard way!

    IVF is a scary thing to get into. I promise you that if you need to use it, it becomes second nature eventually and you'll be okay. But, why not try an iui or two and see what happens? Best of luck to you! You'll find great ladies here to support you through whatever treatment you choose and help you make up your mind if you need to make the big jump to IVF!

    BabyFruit Ticker

     ttc #2 since 2004 Me (35): Stage 3 Endo, DH (34): High DNA Frag

    IVF/ICSI #2: April 2014: BFP!!!!!!

    ET of 2 great quality embryos. + BFP on 9dp5dt. Beta #1 (10dp5dt): 257, Beta #2 (14dp5dt): 1561,

    Beta #3 (21dp5d5): 8,172. Wow. It seems this is actually working. Shocked beyond belief.

    1st u/s @6w5d: Baby A hb 124, Baby B hb 127 (Both measuring perfectly!)

    Lost baby A. Praying that baby B stays healthy. Baby B hb 175 at 11 weeks

    It's a GIRL!!!

    imageimageimage

     

     

    My Blog

  • No success with the IUIs that we did.  Looking back I wish I hadn't wasted the time with the IUIs and went straight to IVF from the start. 

    **** siggy warning - bfp & loss ****   ---- All Welcome ---

    Me: 44 - Hashimoto's (under control), DH: 38 - (minor issues)


    IUIs: 2 in 2012 ... Both BFN
    IVF #1: 10/16/13 ... BFP, however it was not viable and ended in an early loss at 7weeks.

    IVF #2: Feb '14 ... Cancelled. Positive beta at baseline appt, became very early loss.
    IVF #2: Apr '
    14 ... Retrieval Only. 2 embryos made it to day 3 freeze & will be batched with IVF #3 for PGD testing.
    IVF #3: June '14
    ...
    Retrieval Only. 4 embryos growing, all arrested before day 5. Two from April thawed, but also arrested.
    Currently benched while determining how to proceed.

    "Keep going until you can't fail"

     

    image   image

     image  image


  • If it would make you more comfortable to try an IUI or two prior to moving straight to IVF, I say go for it.  Our numbers are similar to yours & we had 5 failed IUI's before moving to IVF.  If I could go back, I would have done a max of 3 & then moved on.  We ended up changing RE's as mine still wanted to go onto a sixth IUI.  I was diagnosed with DOR at the first appointment with the new RE so I am glad we decided to move onto a more aggressive approach.  Best of luck with whatever you decide.

    Me (36) - LOR, DH (34) - MFI (low count & poor motility)

    TTC since 01/2012

    11/2012-04/2013 Unmonitored Clomid cycles through OB/GYN; Referred to RE

    05/2013-Benched due to cyst

    06/2013 - Clomid 50 mg + HCG Trigger + TI = BFN

    07/2013 - Clomid 50 mg + HCG Trigger + IUI #1 = BFN

     08/2013 - Clomid 50 mg + HCG Trigger + IUI #2 = BFN

    09/2013 - Benched for lap & hysteroscopy (Stage II Endo Removed)

    10/2013 - Menopur + HCG Trigger + IUI #3 = BFN

    11/2013 - Menopur + HCG Trigger + IUI #4 = BFN

     12/2013 - Clomid + HCG Trigger + IUI #5 = BFN

    2/2014 - IVF #1 - Microdose Lupron Flare Protocol - 5R/4M/4F w/ICSI; 2 embies transferred on day 3 (none to freeze)

    2/27/14 - First BFP Ever!!!  EDD 11/3/14

     

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  • To be honest, I wouldn't waste time and money on IUIs with MFI. It may SEEM cheaper in the short-term, but the success rates are so much lower than IVF w/ ICSI that it could end up costing a lot more. Plus, the IUI itself may seem cheaper, but with monitoring and medications it could end up costing quite a bit. We did two unsuccessful IUIs (with donor sperm since DH is about like your DHs) and it ended up costing as well over $2,000 per cycle. I wished we would've saved the money and just went straight to IVF.

    N14 Nov. Siggy: CELEBRATION!

    image image
    TTC since 2011
    Aug. - Sept. 2013 - dIUIs = BFNs
    January 2014 - IVF = 3 freezer babies
    March 2014 - FET of AA and AB blast = BFP! Twins! 
    Nov. 7, 2014 - Wilhelmina "Willa" Suzanne (4lb 14oz) and Ari Jose (6lb 4oz) were born via CS
    image image
     
    image image image image 

    Lilypie Premature Baby tickers
  • We also have MFI... We are now on year 11 and finally moved on to IVF.  If I knew how much trouble I would have, I would have gone straight to IVF.

    DH 38- Low Everything
    Me 33- AMH .9
    Married 11 years
    2002-current IUIs, meds, natural = All BFN

    Aug. '13  Attempt at IVF #1 with Lurpon Flare- Canceled due to ovulation through Lupron.
    Sept. '13 - We will try again with EPP.

    October '13 Started BCP for December IVF. Long Lupron protocol. Canceled due to ovulation through Lupron.

    April '14 Planning IVF attempt #3. Adding Cetrotide. Doc consult at the end of this month. 

    imageimage                                                   


  • Thanks for all of the help!  So nice to talk to some people who don't just tell me to take more vitamins and see an acupunturist!  I think I will still do a couple of rounds of IUI, just for peace of mind.

    What do PAIF and SAIF stand for?  It would be nice to hear a few success stories as well, but I am new to the forum and have not figured out where those would be. 

  • amaranth9 said:

    What do PAIF and SAIF stand for?  It would be nice to hear a few success stories as well, but I am new to the forum and have not figured out where those would be. 

    Pregnant after infertility
    Success after infertility

    They are different forums on the same site. The people on this forum are still trying, but the women on those boards have found success.
    Pregnancy Ticker

    TTC #1 since June 2012
    Me (28) - DOR (AFC <10, undetectable AMH, >10 FSH), homozygous E429A MTHFR
    DH (29) - MFI low count and morphology

    September 2013 IUI#1 - Clomid + Trigger + IUI = BFN
    October 2013 IUI#2 - Letrozole + Menopur + Trigger + IUI = BFN

    Nov 2013 IVF/ICSI #1 - Protocol: BCP prep, high doses Menopur and Bravelle (12 days), ganirelex
    Results: 5 retrieved / mature, 4 fertilized, 1 arrested and 3 complex abnormal after day 3 PGS = Cancelled after ER
    Jan/Feb 2014 IVF/ICSI #2 - Protocol: Estrogen priming, high doses Menopur and Bravelle (11 days), microdose lupron
    Results: Cancelled after 11 days of stims due to low response and E2 levels
    Feb 2014 IVF/ICSI #3 - Protocol: No prep, low dose Menopur (6 days), ganirelex, Bravelle booster with trigger
    Results: 1 retrieved / 0 mature = Cancelled after ER

    Officially moving on to embryo adoption! We used and love Embryo Adoption Services of Cedar Park
    October 2014 FET #1 - BCP/Lupron/Estrace/Prometrium, transferred 2 of 4 from match #1, BFN
    December 2014 FET #2 - BCP/Lupron/Estrace/Prometrium, transferred 2 of 4 from match #1, BFN
    March 2015 FET #3 - BCP/Lupron/Estrace/Prometrium, transferred 2 of 6 from match #2, BFN
    May 2015 FET #4 - BCP/Lupron/Estrace/Prometrium, lost 2 to thaw, transferred 2 of 6 from match #2, BFN
    October 2015 FET #5 - Natural cycle, lost 1 from match #3 and 1 from clinic backup to thaw, transferred 1 backup, BFN
    February 2016 FET #6 - Natural cycle, transferred 1 from match #4, B FREAKING P!
    Beta 1 = 162, Beta 2 = 316, doubling just over 48 hours

     

  • We have severe MFI and did not have success I just wanted to say good luck!
  • We had MFI, with motility issues.  His motility was 0%, caused but what the dr believes was medication (propecia).  A few months after stopping propecia, my husband's motility went up to 30% and 40%.  We did three rounds of IUI, mainly because that was covered by insurance.   I did not have to take medication.  Our RE said that there was a possibility of us getting pregnant on our own, but that never happened.  After the 3 failed IUIs, we went to IVF.  I felt more in control with IVF since the RE could make the sperm and egg meet.  We went with ICSCI, and our 2nd cycle, which was a frozen embryo transfer was successful. I'm 12 weeks along, and everything so far is good.  I'm also AMA, and was 35 when we started IVF but am 36 now.  Best of luck.
    <a href="http://www.thebump.com/?utm_source=ticker&utm_medium=HTML&utm_campaign=tickers" title="Getting Pregnant"><img src="http://global.thebump.com/tickers/tt1bbf31.aspx" alt=" Baby Birthday Ticker Ticker" border="0"  /></a>
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