Infertility

PIO graduates

Tonight was my first PIO injection and I was pretty scared. When we first started IVF way back when my DH had to coax me for an hour before he gave me my subcutaneous shots. So that gives you an idea of my fear level. Anyway I did really well staying calm and iced before hand. When it came time I didn't feel a thing except a small poke. It was so small that I had to ask DH if it was in! (He lied and said no... LOL)

My question is, does it get worse over time? Because this really was nothing at all. He massaged for a few minutes after with a warm facecloth and I've been sitting on a heating pad for a half an hour now. :)

TTC since 4/12 
Me: 32, All clear, DH: 34, low count  
IVF /ICSI: 4/18/13~ OHSS~Freeze-all 
FET #1  6/28/13 BFN 
 FET #2  7/29/13 BFN
FET #3  12/16/13 BFN
*NEW RE*
IVF/ICSI #2  3/18/14 BFP, twins m/c 9w4d
IVF/ICSI #3 08/25/14 BFN
FET #4 10/14 BFN
IVF/ICSI #4 1/23/14 BFP Twins!
image


Re: PIO graduates

  • I've never done PIO, so I don't know (I've always had to do Endometrin... vag supps... yuck). But wanted to say good job!! ;) Good luck moving forward!
    **SIGGY WARNING**

    Me: 32 DH: 35  TTC#1 since March 2012
    Dx: Poor Embryo Quality, Arcuate Uterus, Poor Uterine Blood Flow, Mild Endo, 
           Protein S Deficiency, Sjorgen's Syndrome 

    IUI #1-5: BFN
    Laparoscopy & Hysteroscopy: minimal endo, partial septoplasty
    IVF #1: 10R/6M/6F ~ Day 3 ET = BFN
    IVF #2: 14R/9M/5F ~ transfer canceled ~ all embryos arrested at 1-2 cell stage
    IVF #3: 9R/5M/5F ~ 1 frosty!
    IVF #4 (FET #1): BFN

    IVF #5 (DE IVF #1 with Dr. KK protocol): Currently PREGNANT!!!!!!
    Synthroid + Prednisone + Metformin + Baby Aspirin + Supplements Galore = 15+ pills a day
    Lupron + Lovenox + Delestrogen + IVIG + B/W = 2-5 pokes a day
    19R, 17M, 17F - transferred two Grade A blasts 11/16, four frosties!!!
    Beta #1 11/24 (13dpo/8dp5dt) = 367 ~ Beta #2 11/26 (15dpo/10dp5dt) = 709
    Beta #3 11/29 (18dpo/13dp5dt) = 1,997 ~ Beta #4 12/1 (20dpo/15dp5dt) = 3,403

    imageimageimage

    My Blog: Running and Dreaming for Two ~ All are Welcome!
  • I am lucky and get to do PIO and supps.  The heat and massaging really help keep the muscle from knotting up and getting sore.  I also found that getting up and walking around help too.  The few times I didn't get up and move around, I was sore the next day.

    imageimageimageimageimage

     

    image

    TTC #1 since August 2011

    My Blog

    September 2012: Start IF testing

    DH (32): SA is ok, slightly low morph, normal SCSA  Me (32): Slightly low progesterone, hostile CM, carrier for CF, Moderately high NKC, High TNFa, heterozyogous mutated Factor XIII, and +APA

    October 2012-May 2014: 4 failed IUIs, 3 failed IVFs, and 1 failed FETw/donor embryos

    November 2014: IVF w/ICSI #4 Agonist/Antagonist with EPP and Prednisone, Baby Aspirin, Lovenox, and IVIG for immune issues.  Converted to freeze all due to lining issues.  2 blasts frozen on day 6!

    January 2015: FET #2 Cancelled due to lining issues

    April 2015: FET #2.1


    PAIF/SAIF Welcome!

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  • Glad you posted this. I will be starting PIO on Friday and am so scared. Glad to hear it wasn't so bad.  I have no idea how to do it yet since meds are coming on Thursday. I wish I could just take crinone but RE says PIO is better for FET.

    GL
    ***SIGGY WARNING***

    DX: Unexplained
    6 Failed IUIs (Clomid and Gonal F).  
    IVF #1 began August 2013- BC, 4 days of Estrace, stimmed with Gonal F and Menopur, Ganirelix, 9R 5M 5F, Medrol and Doxycycline, 5 day transfer of 2 early blastocysts- good quality, Progesterone, Estrace, and baby aspirin, BETA on 9/20 BFN,   IVF #2 began September 2013, stimming with Gonal F (higher dose) and Menopur, Ganirelix, 18R 14M 9F with ICSI, 5 day transfer of 2 BBs one was starting to hatch, 2 frosties: 1  BB and 1 AC, BETA on 10/21, BFN BETA was a 5- chemical 
    Getting some more testing and trying to figure out what the issue is before FET in December, started acupuncture on 11/10, RLP and some other BW nothing major to report except slightly high Prolactin. Prolactin was slightly high when I started with my RE and I already had an MRI which was Neg.  Endo biopsy=negative.  WTF is wrong with us???
    12/18/13 FET of 1 BB and 1 AC.  Hoping for a miracle.  Beta 12/26 Low BETA-8 2nd BETA 5- chemical
    After 3 failed transfers IDK where to go from here.  Still no real answers as to why this isn't working.  Getting a second opinion in February and looking into immune testing.  
    2/14- NEW RE- Immune testing showed a partial dq alpha match with DH- On prednisone and did intralipids prior to transfer.  3/14 Lupron, gonal f, menopur, HGH.  ER 15 mature all 15 fertilized!  5dt of an early blast grade 1 and an expanded blast grade 2.  BETA on 4/21.  1 grade 2 embryo frozen
    BETA #1 59 BETA #2 148 BETA #3 283 BETA #4 2,783! US at 6w2d shows 1 bean measuring right on track! HR 121.  US at 8w3d measuring on track HR 177. Released form my RE.  EDD 12/28


    All Welcome
  • PIO scares me to death. I have a few weeks before I have to do my first PIO inject. Why why why does PIO scare everyone??

    @babydreams13 I would like a full report on your PIO experience too! :)
    ******************** BFP Warning *******************
     
    I'm 29 and DH is 32 we have a MFI (low count) 
    IVF #1 starting in August. ER 9/5/13 23 eggs we are fertilizing 15. 9 frozen
    ET 9/10 - transferred 1 perfect 5AA blast
    7dp5dt BFP ~~ Beta on 9/19 - 77.4 Beta #2 on 9/21 - 357
    Low heartbeat on 10/7 86, lower heartbeat on 10/11 76, no heartbeat 10/14/13. D&C 10/15/13
    Tests revealed MTHFR c677t mutation, put on Folgard.
    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    FET #1 1/6/14 - 4BB blast - BFN
    FET #2 - 3/3/14 - 5AB Blast -- Beta #1 3/12 - 152 -- Beta #2 3/14 - 358
    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
    FET #3 06/09/16 - 5AB Blast - Beta #1 6/18- 245 -- Beta #2 06/20 - 600
     PAIF/SAIF/PAL/SAL welcome!

  • I've been on PIO shots for about two weeks now.  They aren't so bad.  I don't ice, heat or massage.  I just prep myself for a bit of a sting.  Some shots are a little worse than others and some I don't feel at all.  I have to do PIO shots every day and Estrogen shots every third day until my 2WW is over.   

    Married September 17, 2011.
    Me 38, PCOS
    H 43, SA normal.
    TTC #1 since November 2011.
    HSG - both tubes clear.
    Metformin+ Clomid + Prometrium (Ob/Gyn)
    January 2012- Chemical Pregnancy
    June 2012- BFP- Ectopic (5 weeks), Methotrexate
    November 2012- BFP- Miscarriage (5 weeks),D&C(12/14/12)

    December 17, 2012 first apt with RE
    Metformin + Folgard+ Clomid+ Bravelle + TI +Prometrium (RE)
    March 2013- 2 follicles- BFN
    April 2013- 2 follicles- BFN

    Oct 2013, IVF #1- fresh cycle cancelled due to increased progesterone
    ER 11/7/2013- 20 retrieved, 19 mature, 14 fertilized naturally, 3 blasts frozen
    FET #1- 12/6/13, 2 blasts xfered- BFN

    FET #2- Cancelled while sitting in the waiting room... blast didn't survive thaw

  • I did them for IVF#1 and was scared too.  They are not bad.  I didn't ice...just massaged afterwards and then kept moving....i.e. walking, doing laundry, etc.  My husband was more nervous to have to give them to me, but remember to put your weight on the leg NOT getting the shot in.  It allows the muscle to be relaxed.  You'll do great and in a week will be like "what was the big deal?" :) 

     

    ************** Siggy Warning************


    Married August 2012 -- Me (40 yrs old) My husband (45 yrs. old) 

    RE referral from ObGYN in late Jan. 2013 -- Testing Confirms Unexplained IF 

    IUI #"s1 - 3 (Femara + IUI) April - June 2013 - all BFN

      Decided to do IVF... Began stimming on September 10th!  Egg Retrieval 9/20/13.  19 eggs: 6 to mature to freeze after 6 fertilized with ICSI

     3 morula stage embryos transferred on 9/25/13.....Beta #1 on 10/4/13/ = 7.5  Beta #2 on 10/6/13 =  negative

      IVF#2 - Lupron plan  (set to begin on 10/28/13)  (Planning on thawing and fertilizing our 6 eggs with ICSI as well as all of the mature eggs they retrieve with this fresh cycle.)

     Late October 2013 - ectopic pregnancy - methotrexate injection....benched 3 months

    CD1 - 12/5/13...Lupron set to start on 12/26/13; CD1 - 1/2/14....Baseline 1/3/14....begin follistim tonight and continue with lupron.  (Got my calendar today!  IVF#2 is a go!)

    ER = 1/14/14  (11 eggs....9 were mature. 9 fertilized.  Of the 6 mature eggs we thawed, only 4 fertilized.  At this time, we have 13 eggs fertilized and growing.  Waiting for news about a 3-day or 5-day transfer.)

    ET = 1/19/14  (5dt).....3 blastocysts transferred!   (All nine embryos didn't make it to freeze.  =(  )

    Beta #1 = 1/28/14   (2 weeks after ER)  BFP! 209 (9dp5dt)   EDD 10/7/14

    Beta #2 - 1/30/14  (11 dp5dt) 302

    Beta #3 - 2/3/14  (15 dp5dt)  1222 

    Ultrasound set for 2/17/14......TWINS!        Twin A - HR 124 bpm; Twin B - HR 126 bpm

    Final Ultrasound with RE 3/10/14 - Twin A - HR 176 bpm; Twin B - HR 177 bpm.

     PAIF/SAIF Welcome! 

     

     

    imageimage 

    imageimageimage

     

  • I will be doing them again for the second FET in jan. I find that my body starts to getting used to if after the first week or so. It's sore the first few shots and then they get easier. For sure I always do the heating pad after. The times I don't do it I knot up bad!!!
    Me 34 and DH 39 married in aug. 2002
    Did 5 round of clomid 2010 =BFN
     High levels of NK CELLS DX sept.2012 DOR:# 0.02 
    IVF #1 May 2012  ER 4, EF 2, ET 2 =BFN
    MINI IVF Oct.2012  Cancelled 10-27-12
    Ivf #3 Antagonist Protocol April 2013
    Shared cycle..Donor cycled in July Got 12 eggs 9 fertilized and 8 frozen!!
    DE FET #1 Sept. 3rd 2013 FIRST BFP EVER 5dp5dt
    miscarried Sept 24th at 5 weeks 5 days
    Etopic  D&C and hysterscopy Nov 5 2013
    dx with pre genetic blood clotting dec 2013
    FET #2 Jan 31st  2014 
    Miscarried for a second time again at 5 weeks 5 days
    Currently fostering to adopt an amazing little 1 year old boy..P.J!
    FET#3  is Oct 29th 2014
    BFN on fet #3
    Last and FINAL FET coming JAN 28th 2015
    Everyone Welcome






  • Ashris13 said:
    PIO scares me to death. I have a few weeks before I have to do my first PIO inject. Why why why does PIO scare everyone??

    @babydreams13 I would like a full report on your PIO experience too! :)
    Okay full report here: Just got my first PIO inject about half hour ago.  I watched a video on youtube by the Sher institute.  I wet a wash cloth and then microwaved it for a minute. I applied it to the area.  DH prepped the needle. Today I started with 1/2 ml and tomorrow and onward will be 1 ml.  I laid down and DH administered the shot. Right before he did it I was laughing and crying, it was weird.  He then massaged the area.  Honestly it wasn't bad at all. A little sting in the beginning.  I am keeping pressure off of it right now and leaning on my other side while sitting on the couch.  I hope tomorrow with the higher dose its the same feeling.  

    GL, you got this!
    ***SIGGY WARNING***

    DX: Unexplained
    6 Failed IUIs (Clomid and Gonal F).  
    IVF #1 began August 2013- BC, 4 days of Estrace, stimmed with Gonal F and Menopur, Ganirelix, 9R 5M 5F, Medrol and Doxycycline, 5 day transfer of 2 early blastocysts- good quality, Progesterone, Estrace, and baby aspirin, BETA on 9/20 BFN,   IVF #2 began September 2013, stimming with Gonal F (higher dose) and Menopur, Ganirelix, 18R 14M 9F with ICSI, 5 day transfer of 2 BBs one was starting to hatch, 2 frosties: 1  BB and 1 AC, BETA on 10/21, BFN BETA was a 5- chemical 
    Getting some more testing and trying to figure out what the issue is before FET in December, started acupuncture on 11/10, RLP and some other BW nothing major to report except slightly high Prolactin. Prolactin was slightly high when I started with my RE and I already had an MRI which was Neg.  Endo biopsy=negative.  WTF is wrong with us???
    12/18/13 FET of 1 BB and 1 AC.  Hoping for a miracle.  Beta 12/26 Low BETA-8 2nd BETA 5- chemical
    After 3 failed transfers IDK where to go from here.  Still no real answers as to why this isn't working.  Getting a second opinion in February and looking into immune testing.  
    2/14- NEW RE- Immune testing showed a partial dq alpha match with DH- On prednisone and did intralipids prior to transfer.  3/14 Lupron, gonal f, menopur, HGH.  ER 15 mature all 15 fertilized!  5dt of an early blast grade 1 and an expanded blast grade 2.  BETA on 4/21.  1 grade 2 embryo frozen
    BETA #1 59 BETA #2 148 BETA #3 283 BETA #4 2,783! US at 6w2d shows 1 bean measuring right on track! HR 121.  US at 8w3d measuring on track HR 177. Released form my RE.  EDD 12/28


    All Welcome
  • Hi ladies,

    Good discussion going on here about PIO. The first week or so wasn't bad at all for me, I iced and massaged after. No lumps or pain really. However, I am really starting to get quite sore and even having some pain (just in general, not from the shot itself). I think that's because I haven't been using heat. Guess I thought since it started out okay, I didn't really need it, but boy am I going to need to start!

    However, I'm in my 2ww and wanted to double check that a heating pad would be okay to use during this time period after the transfer..........
  • congrats!! I only did PIO for about 3 weeks, and was also SO nervous!!! It really is not bad at all!! I didn't get sore or have any reaction fortunately. After the three weeks I was a little tender but not bad! Good luck! :)

    **** Ticker Warning ****

    Me: 37, DH: 38 Married since 2005, TTC since 2007

    IVF#1 February 2013 - 6R, 4M, 3F - transferred 2 day 3; 1 frozen - BFN

    IVF#2 May 2013 - Menopur, Follistim, Ganirilex - 16R, 13M - freeze all eggs due to MFI 0% Motility day of retreival

    FET September 2013 - 9 eggs thawed, 0 fertilized :( transferred frostie from IVF #1 - Estrace & PIO - BFN

    **Change RE**

    January 2014 - IVF #3 (Lucky #3?!)  ER 2/5/14 19R, 16M, 11F with PICSI.

    2/10/14 Transferred 2 AA day 5 blasts <3<3, 5 Frozen - Estrace & Endometrim (which IMO is worse than PIO!!)

    Beta 2/24/14 Beta #1: 2229, Beta #2: 3577 BFP!!

    6 week u/s - TWO heartbeats <3

    EDD 10/30/14

     

    ***** All Welcome *******


  • Hi ladies,

    Good discussion going on here about PIO. The first week or so wasn't bad at all for me, I iced and massaged after. No lumps or pain really. However, I am really starting to get quite sore and even having some pain (just in general, not from the shot itself). I think that's because I haven't been using heat. Guess I thought since it started out okay, I didn't really need it, but boy am I going to need to start!

    However, I'm in my 2ww and wanted to double check that a heating pad would be okay to use during this time period after the transfer..........
    Yes, a heating pad is okay to use, my nurse said that if you are icing then you should sit on heat for a little bit afterwards. I noticed that the longer I sit on it the better. So usually I heat for 30 minutes or more, on the couch watching tv/reading. :) 

    TTC since 4/12 
    Me: 32, All clear, DH: 34, low count  
    IVF /ICSI: 4/18/13~ OHSS~Freeze-all 
    FET #1  6/28/13 BFN 
     FET #2  7/29/13 BFN
    FET #3  12/16/13 BFN
    *NEW RE*
    IVF/ICSI #2  3/18/14 BFP, twins m/c 9w4d
    IVF/ICSI #3 08/25/14 BFN
    FET #4 10/14 BFN
    IVF/ICSI #4 1/23/14 BFP Twins!
    image


  • For me, the needle going in doesn't hurt a bit. The actual muscle starts to get sore an hour or so after (like a really good glutes work out) and it hurts to walk a bit.
    Off BCP 5/2010
    Obsessive Charting & OPK'ing 
    Clomid 3/2011: BFN
    HSG: Normal
    Dx: DOR (at 29... currently 31)
    IVF #1   7/2011 On BCP &  Lupron 10iu 8/6: Stim Start (Menopur & Gonal F
    Day 14 of stims: One 19.9 and one 20 follicle Estro: 908.
    ER 8/21/11. 4 Eggs... only 2 were mature enough. ET: 8/24 ICSI
    9/6 Beta: 9.2 (low positive)  9/7 HPT: BFN
    9/8/11 ANOTHER Beta: BFN
    TTC Naturally
    3/2012 Lap done, very little endo. What now? 
    5/2012 IUI FAIL!
    IVF# 2: 12/13/13- 1 Embie transferred
    12/24/13 Beta- 20
    12/30/13 Beta- Hcg in the negatives. BFN
    TTC Naturally again...

    PAIF/SAIF Welcome!
  • The heating pad before and after is the key (my re says only heat, no icing)... The heat numbs the skin before the shot and soothes the muscle after. The few times I didn't heat, it was painful and my muscles hurt for days! In fact I have two black and blue marks on my tush right now but they don't hurt and I'm convinced it's bc of the heat.
    Me: 34 - low ovarian reserve
    DH: 40 - no issues  

    3 failed IUI's 

    IVF #1 3/12 - 13 eggs, 9 fertilized,  2 transferred (1 grade 2 blast, 1 early blast), no frosties, 3/30/12 - 9dp5dt spotting, BFNs

    IVF #2. 7/12 - 18 days of stims, 3 mature eggs, 3 fertilized (ICSI), 3 transferred (9, 8, 7 cell) on day 3.  First beta - 8/21/12 = 105, beta #2 - 8/23/12 = 268, beta #3 - 8/30/12 = 2,352. 2nd u/s - 9/4/12. Baby Boy born 5/1/2013.

    IVF #3 Now (12/13). AMH is very low - 0.19. ER (12/5) 12 eggs, 10 mature, 7 fertilized using ICSI. 3 transferred (8,8,8 cell - all grade 2) on day 3. First beta - 12/21/13 = 126, beta #2 - 12/23/13 = 400, beta #3 - na (office was closed for new year's). First sonogram - TWINS aka OMG! -  


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