what determines ...(embryo question)

Smals

if an egg makes it to day 5?  I know about cells splitting but what determines or stops that?

Im new to ivf.  i had 5 eggs fertilized and am curious if all or any will make it to day 5.

i also want to get a better understanding of this

O2girl

Shortest explanation.... The quality of the egg and the quality of the sperm.

kz's_girlygirl

Cells continue to grow or stop growing for a variety of factors, not all of which I understand.  In my case, chromosomal abnormalities caused the embryos to stop growing immediately after fertilization. 

Here's a blog I found that gives an overview. 
I hope yours continue to develop and that you get great results!!

Smals

hmmmm...thanks

katib77

I've heard that depending on age and DX and egg quality 15-40% of eggs usually make it to full blast (day five or six stage).  So if you have 10 mature and fertilized eggs, depending on your age and DX you can expect about 1-4 eggs to make it to day five.  That might seem low but remember back when we first started TTC and you heard "A healthy couple has a 20% chance any month even with perfect timing of getting PG"? It's because even young, healthy women have some defective eggs out of the million we're born with.  So even some young fertile without IF issues, if they did IVF would not have all make it to day five.  It's just the nature of creating life.  Survival of the fittest if you will.  

I had seven fertilized eggs and I'm 35.  I had one make it to full blast and a second that made it to early blast but stopped growing before full blast.  To me this makes sense because 15% of 7 is 1.  (25% of 7 is 1.75, and since there is no such thing as three fourth of an embryo the mathematician brain of mine says well one fully made it and one came close).  Maybe if I was a few years younger that would have given me 30% make it, which would mean 2 blasts make it.

:::SHRUGS:::  I don't know if my rambling makes any sense but it helped me accept our numbers.  

Smals

katib77 said:

I've heard that depending on age and DX and egg quality 15-40% of eggs usually make it to full blast (day five or six stage).  So if you have 10 mature and fertilized eggs, depending on your age and DX you can expect about 1-4 eggs to make it to day five.  That might seem low but remember back when we first started TTC and you heard "A healthy couple has a 20% chance any month even with perfect timing of getting PG"? It's because even young, healthy women have some defective eggs out of the million we're born with.  So even some young fertile without IF issues, if they did IVF would not have all make it to day five.  It's just the nature of creating life.  Survival of the fittest if you will.  

I had seven fertilized eggs and I'm 35.  I had one make it to full blast and a second that made it to early blast but stopped growing before full blast.  To me this makes sense because 15% of 7 is 1.  (25% of 7 is 1.75, and since there is no such thing as three fourth of an embryo the mathematician brain of mine says well one fully made it and one came close).  Maybe if I was a few years younger that would have given me 30% make it, which would mean 2 blasts make it.

:::SHRUGS:::  I don't know if my rambling makes any sense but it helped me accept our numbers.  

makes sense. thanks

wish the rate was higher. 15 % isnt a lot.  I am 36 (so is husband). I only had 5 fertilized.  hopefully 1 or 2 will make it to day 5

Twinkie0612

To piggy back on what @katib77 said. I had 5 embryos on day 3. My clinic pushes everyone to day 5, I had I embryo out of five make it to early blast on day 5 and was transferred. I had another that made it to the compacted stage on day 5, but didn't make it to blast on day 6 for freezing. My first cycle I only had 3 embryos and none of them made it to day 5.

poohniki

O2girl said:

Shortest explanation.... The quality of the egg and the quality of the sperm.

Here is a LONG article and somewhere in it they explain how up until day 3 it is the mother's DNA that determines if the egg continues, but after day 3 the sperm is taken into account.

https://issuu.com/nj_physician_magazine/docs/njp_june_2013_final

katib77

Smals said:

katib77 said:

I've heard that depending on age and DX and egg quality 15-40% of eggs usually make it to full blast (day five or six stage).  So if you have 10 mature and fertilized eggs, depending on your age and DX you can expect about 1-4 eggs to make it to day five.  That might seem low but remember back when we first started TTC and you heard "A healthy couple has a 20% chance any month even with perfect timing of getting PG"? It's because even young, healthy women have some defective eggs out of the million we're born with.  So even some young fertile without IF issues, if they did IVF would not have all make it to day five.  It's just the nature of creating life.  Survival of the fittest if you will.  

I had seven fertilized eggs and I'm 35.  I had one make it to full blast and a second that made it to early blast but stopped growing before full blast.  To me this makes sense because 15% of 7 is 1.  (25% of 7 is 1.75, and since there is no such thing as three fourth of an embryo the mathematician brain of mine says well one fully made it and one came close).  Maybe if I was a few years younger that would have given me 30% make it, which would mean 2 blasts make it.

:::SHRUGS:::  I don't know if my rambling makes any sense but it helped me accept our numbers.  

makes sense. thanks

wish the rate was higher. 15 % isnt a lot.  I am 36 (so is husband). I only had 5 fertilized.  hopefully 1 or 2 will make it to day 5

Try to remember it can be the 40% group.  And there are those that go above the curve.  I've seen plenty of DOR or POF gals that have only one or two fertilized and get PG so clearly that happens.  FX for you for one or more rockstar embies out of your five.

katib77

**Also remember that was data I was looking for for freeze all cycles.  If you are doing fresh ET they can chose to put embies back on day 3 and I've seen tons get PG with morula's and 6-10 cell embies.  

dreamingofdimples

I'm 36 and hubs is 37. The numbers we were given at our clinic is that 50% of fertilized embryos will usually make it to day 5 blast. Since we had 4 fertilized, we froze on day 1 and decided to cycle again. 

We figured if 2 make it to day 5 blast (50%) and and at my age 60% are usually normal when you do CCS testing...odds were I'd get one normal to transfer if I moved forward. If I was lucky and beat the odds...maybe 2 of them. And if I was unlucky none. Game over. 

I hope you beat the odds and all of yours make it!

kz's_girlygirl

**bfp mentioned**


On our last cycle, we only had 1 fertilized egg, transferred on day 2 at a mere 4 cells and got pregnant. We lost our baby, but it was bc of something totally unrelated. It can and does happen!

Smals

katib77 said:

**Also remember that was data I was looking for for freeze all cycles.  If you are doing fresh ET they can chose to put embies back on day 3 and I've seen tons get PG with morula's and 6-10 cell embies.  

My dr only does day 5 transfers

Smals

poohniki said:

O2girl said:

Shortest explanation.... The quality of the egg and the quality of the sperm.

Here is a LONG article and somewhere in it they explain how up until day 3 it is the mother's DNA that determines if the egg continues, but after day 3 the sperm is taken into account.

https://issuu.com/nj_physician_magazine/docs/njp_june_2013_final

Just read article ...thanks